Email: dwest@chori.org
Phone: 510-450-7987

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Overview

"We have two goals in our laboratory: 1) to understand and characterize the molecular genetic basis of metabolic disease using mouse models; and 2) to develop and characterize knockout mouse models of disease for use by the biological research community."

Obesity and Type 2 Diabetes are serious prevalent conditions that lead to significant morbidity and mortality in our population. There is a major genetic component contributing to risk for developing these diseases and Dr. West is using and developing mouse models in order to identify the genes conferring risk and to characterize their mechanism of action. Dr. West is also collaborating on a project to create and phenotype 312 knockout mouse models. The genes selected to knockout include genes that are putatively involved in many human diseases including metabolic, cardiovascular, infectious diseases and cancer. These knockout models are publicly available and the phenotyping data can be viewed at www.kompphenotype.org.

Revised: Thursday, September 27, 2012 2:27 PM

 

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