MARK C. Walters, MD
Director, CHO Blood & Marrow
Transplant Program
An Overview


Phone: 510-428-3374



  1. Walters, M., Kim, C., and Gelinas, R. Characterization of a DNA binding activity in DNAse I hypersensitive site 4 of the human globin Locus Control Region, Nucl Acids Res 19:5385-5393, 1991.

  2. Walters, M., and Martin, D. Functional erythroid promoters created by interaction of GATA-1 with CACCC and AP-1/NFE-2 elements. PNAS USA 89:10444-10448, 1992.

  3. Walters, M., Matthews, D., and Sullivan, K. Bone marrow transplantation for hemoglobinopathy and sickle cell disease, Recent Advances in Haematology 7, Churchill Livingstone, Inc., NY, 119-134, 1993.

  4. Walters M, Sullivan KM, O’Reilly RJ, Boulad F, Brockstein J, Blume K, Amylon M, Johnson FL, Klemperer M, Graham-Pole J, Appelbaum FR, Hansen JA, Sanders JE, Storb R, and Thomas, E.D. Review of marrow transplantation for thalassemia in the US and Canada, Am J Pediatr Hem/Onc 16:11-17, 1994.

  5. Walters, M.C., Sullivan, K.M., Bernaudin, F., Souillet, G., Vannier, J.P., Johnson, F.L., Lenarsky, C., Powars, D., Bunin, N., Ohene-Frempong, K., Wall, D., Plouvier, M.E., Bodigoni, P., Lutz, P., Sanders, J.E., Matthews, D.C., Patience, M., Appelbaum F.R., and Storb, R. Neurologic complications after allogeneic marrow transplantation for sickle cell anemia. Blood 85:879-884, 1995.

  6. Walters, M.C., Fiering, S., Eidemiller, J., Magis, W., Groudine, M., and Martin, D.I.K. Enhancers increase the probability but not the level of gene expression. PNAS, USA 92:7125-7129, 1995.

  7. Sullivan KM, Walters MC, Bernaudin F, Souillet G, Camitta B, Davies S, Eckman J, Mentzer W, Poward D, Vichinsky E, Wonke B, Dickerhoff R, Kurtzberg J, Ohene-Frempong K, Orringer J, Parkman R, Patience M, Scott P, Storb R, and the Collaborative Sickle Cell Marrow Transplant Group. Collaborative study of marrow transplantation for symptomatic sickle cell anemia. In: Beuzard Y, Lubin B, Rosa J (eds): Sickle Cell Disease and Thalassaemias: New Trends In Therapy. John Libbey Eurotext Ldt.: Colloque INSERM, p. 571, 1995.

  8. Walters MC, Magis W, Fiering S, Eidemiller J, Scalzo D, Groudine M, and DIK Martin. Transcriptional enhancers act in cis to suppress position-effect variegation. Gene Dev 10: 185-196, 1996.

  9. Walters, M.C., Andrews, N., Magis, W., and Martin, D.I.K. Functional analysis of NF-E2/AP1 motifs from erythroid regulatory sites. Exp Hem 24:445-452, 1996.

  10. Walters, M.C., and Abelson, H.T. Interpretation of the complete blood count. Pediatr Clin N America, 43: 599-622, 1996.

  11. Walters MC, Patience M, Leisenring W, Eckman JR, Scott JP, Mentzer WC, Davies SC, Ohene-Frempong K, Bernaudin F, Matthews DC, Storb R, and Sullivan KM. Bone marrow transplantation for sickle cell disease. N Engl J Med 335:369-76, 1996.

  12. Walters, MC, Patience M, Leisenring, W, Sanders JE, Matthews, DC, Storb, R, and Sullivan, KM and the collaborative sickle cell marrow transplant group. Barriers to bone marrow transplantation for sickle cell anemia. Biology of Blood and Marrow Transplant 2:100-104, 1996.

  13. Sullivan KM, Walters MC, Ohehe-Frempong K. Informed consent for bone marrow transplantation in children (Letter). N Engl J Med 335:1845-46, 1996.

  14. Francastel, C., Augery-Bouget, Y., Prenant, M., Walters, M., Martin, D.I.K., Robert-Lezenes, J. c-Jun inhibits NF-E2 transcriptional activity by association with p18/maf in Friend erythroleukemia cells. Oncogene 14:873-877, 1997.

  15. Sullivan KM, Walters MC, Patience M, Leisentring W, Buchanan GR, Castro O, Davies SC, Dickerhoff R, Eckman JR, Graham ML, Ohene-Frempong K, Powars D, Rogers Z, Scott JP, Styles L, Vichinsky E, Wall D, Wayne A, Wiley J, Wingard J, Bunin N, Camitta B, Darbyshire PJ, Dinndorf P, Klingebiel T, McMahon L, Mentzer WC, Olivieri N, Orringer E, Parkman R, Roberts IAG, Sanders JE, Smith F, and Storb, R. Collaborative study of marrow transplantation for sickle cell disease: Aspects specific for transplantation of hemoglobin disorders. Bone Marrow Transplant 19 suppl 2:102-105, 1997.
  16. Walters MC, Patience M, Leisenring W, Rogers ZR, Dinndorf P, Davies SC, Roberts IAG, Yeager, A, Kurtzberg J, Bunin N, Scott JP, Wall DA, Wayne AS, Wiley J, Darbyshire PJ, Mentzer WC, Smith FO, and Sullivan KM. Collaborative multicenter investigation of marrow transplantation for sickle cell disease: current results and future directions. Biol Blood Marrow Transplant, 3:310-315, 1997.
  17. Sullivan KM, Anasetti C, Horowitz M, Rowlings PA, Petersdorf EW, Martin PJ, Clift RA, Walters MC, Gooley T, Sierra J, Anderson JE, Bjerke J, Siadak M, Flowers MED, Nash RA, Sanders ME, Appelbaum FR, Storb R, and Hansen, JA. Unrelated and HLA-nonidentical related donor marrow transplantation for thalassemia and leukemia: A combined report from the Seattle Marrow Transplant Team and the International Bone Marrow Transplant Registry. Annals NY Acad Sci. 850:312-24, 1998.

  18. Storb R, Yu C, Deeg HJ, Georges G, Keim H-P, McSweeney PA, Nash RA, Sandmaier BM, Sullivan KM, Wagner JL, and Walters MC. Current and future preparative regimens for bone marrow transplantation in thalassemia. Annals NY Acad Sci. 850:287-87, 1998.

  19. Walters MC. Stem cell transplantation for sickle cell disease; in Hematopoietic Cell Transplantation, Second Edition, eds. SJ Forman, KG Blume and ED Thomas. Blackwell Science, Malden, MA, 1998.

  20. Woolfrey AE, Gooley T, Hoffmeister P, Sievers EL, Milner L, Andrews RA, Walters M, Hansen JA, Anasetti C, Bryant E, Appelbaum FR, and Sanders JE. Bone marrow transplantation for children less than two years of age with acute myelogenous leukemia or myelodysplastic syndrome. Blood, 92:3546-3556, 1998.

  21. Walters MC, Fiering S, Bouhassira EE, Scalzo D, Goeke S, Garrick D,Whitelaw E and D. I.K. Martin . The Chicken b-globin 5’HS4 Boundary Element blocks enhancer-mediated suppression of silencing. Mol Cell Biol, 19:3714-26, 1999.

  22. Claire Francastel, Mark C. Walters, Mark Groudine and David IK Martin. A Transcriptional Enhancer Suppresses Silencing of a Transgene and Prevents its Localization Close to Centromeric Heterochromatin, Cell, 99:259-269, 1999.

  23. Walters, MC. Bone Marrow Transplantation for Sickle Cell Disease: Where Do We Go From Here? J Ped Hematol/Onc, 21: 467-474, 1999.

  24. Lorincz MC, Schübeler D, Goeke SC, Walters M, Groudine M, and Martin DIK. Dynamic analysis of proviral induction and de novo methylation: implications for a histone deacetylase-independent, methylation density-dependent mechanism of transcriptional repression. Mol Cell Biol 20: 842-850, 2000.

  25. Walters MC, Storb R, Patience M, Leisenring W, Taylor T, Sanders JE, Buchanan GR, Rogers ZR, Dinndorf P, Davies SC, Roberts IAG, Dickerhoff R, Yeager AM, Hsu L, Kurtzberg J, Ohene-Frempong K, Bunin N, Bernaudin F, Wong W-Y, Scott JP, Margolis D, Vichinsky E, Wall, DA, Wayne AS, Pegelow C, Redding-Lallinger R, Wiley J, Klemperer M, Mentzer WC, Smith FO, and KM Sullivan. Impact of bone marrow transplantation for symptomatic sickle cell disease: an interim report. Blood, 95: 1918-24, 2000.

  26. Reed W, Walters M, Lubin BH. Collection of sibling-donor cord blood for children with thalassemia. J Pediatr Hematol/Onc, 22:602-604, 2000.

  27. Sullivan KM, Parkman R, Walters MC. Bone Marrow Transplantation for Non-Malignant Disease. Hematology (Am Soc Hematol Educ Program) 319-338, 2000.

  28. Fixler J, Vichinsky E, and Walters MC. Stem cell transplantation for sickle cell disease: can we reduce the toxicity? Pediatr Path and Mol Med, 20:73-86, 2001.

  29. Hoppe CC and Walters MC. Bone marrow transplantation in sickle cell anemia. Curr Opin Oncol, 13:85-90, 2001.

  30. W Reed, M Walters and BH Lubin, Sibling donor cord blood banking for children with sickle cell disease. Pediatr Path and Lab Med 20:167--174, 2001.

  31. MC Walters, M Patience, W Leisenring, ZR Rogers, VM Aquino, GR Buchanan, IAG Roberts, AM Yeager, L Hsu, T Adamkiewicz, J Kurtzberg, E Vichinsky, B Storer, R Storb, and KM Sullivan. Stable mixed hematopoietic chimerism after bone marrow transplantation for sickle cell anemia, Biol Blood Marrow Transplant, 12:665-673, 2001.

  32. The Management of Sickle Cell Disease, contributor, ‘Hematopoietic Cell Transplantation’, p. 167-173, NIH Publication 02-2117, June 2002.

  33. P Woodard, BH Lubin, and MC Walters. New Approaches to Hematopoietic Cell Transplantation for Hematological Diseases, Pediatr Clin N Amer, 49: 989-1007, 2002.

  34. Nienhuis AW, Vichinsky E, and Walters MC. Novel therapeutic approaches in sickle cell disease. Hematology (Am Soc Hematol Educ Program) December, 2002.

  35. W Reed, R Smith, F Dekovic, JY Lee, JD Saba, E Trachtenberg, J Epstein, S Haaz, MC Walters, and BH Lubin. Comprehensive Banking of Sibling Donor Cord Blood for Children with Malignant and Non-Malignant Disease, Blood, Blood 101: 351-357, 2003.

  36. F Locatelli, V Rocha, W Reed, F Bernaudin, M Ertem, S Grafakos, B Brichard, X Li, A Nagler, G Giorgiani, P Haut, JA Brochstein, DJ. Nugent, J Blatt, P Woodard, J Kurtzberg, R Miniero, P Lutz, T Raja, I Roberts, AM Will, I Yaniv, C Vermylen, N Tannoia, F Garnier, I Ionescu, MC Walters, BH Lubin, E Gluckman on behalf of the Eurocord transplant group. Related umbilical cord blood transplant in patients with Thalassemia and Sickle Cell Disease, Blood, 101: 2137-2143, 2003. PDF

  37. R Iannone, JF Casella, EJ Fuchs, AR Chen, R Jones, A Woolfrey, M Amylon, KM Sullivan, RF Storb, and MC Walters. Results of minimally toxic non-myeloablative transplantation in patients with sickle cell anemia and b-thalassemia, Biol Blood and Marrow Transplant, 9: 519-528, 2003. PDF

  38. Atkins RC and Walters, MC. Haematopoietic cell transplantation in the treatment of sickle cell disease, Expert Opin Biol Ther. 3:1215-24, 2003. PDF

  39. MC Walters. Sickle cell anemia and hematopoietic cell transplantation: when is a pound of cure worth more than an ounce of prevention? In press, Ped Transpl.



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