The focus of my work is translational research involving hemoglobin disorders,
iron metabolism, transfusion medicine, and fetal hemoglobin regulation.
My research in the area of iron metabolism includes understanding the
effects of inflammation on iron deposition and organ damage. I have received
an RO1 grant to research the differences in iron transport and organ injury
between sickle cell and thalassemia. Preliminary data suggests a significant
difference between these diseases in the transport of iron from the liver
to target organs. As part of this study, we are evaluating new technology
to quantitate early iron-induced organ injury.
In addition, I am currently investigating methods to determine red cell
survival and novel therapy for sickle cell disease. The study involves
the development of new iron chelators to find out whether red cell survival
in sickle cell disease can be increased by chelating iron from the red
cell, thereby decreasing oxidative injury.