Selected Publications 2003-2009
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Protein nanocages

Turano, P, LAlli, D, Felli, IC, Theil, EDC, Bertini, I.. NMR reveals pathway for ferric mineral precursors to the central cavity of ferritin PNAS 2010 107:545-550

Bellapadrona G, Stefanini S, Zamparelli C, Theil EC, Chiancone E. (2009) “Iron translocation into and out of Listeria innocua Dps and size distribution of the protein-enclosed nanomineral are modulated by the electrostatic gradient at the 3-fold "ferritin-like" pores.” J Biol Chem. 284(28):19101-9.

E. C. Theil and D.J. Goss (2009) “IRON HOMEOSTASIS AND DISTRIBUTION: QUESTIONS AND ANSWERS” A contribution to the Chemical Reviews thematic issue “Cellular Metal Homeostasis and Trafficking”. In press. ACS-ASAP E-Pub 092509.

Khan, M.A., Walden, W.E., Goss, D.J., and Theil, E. C. (2009) Direct Fe2+ Sensing by Iron Responsive Messenger RNA/repressor Complexes Weakens Binding, J. Biol. Chem., E-pub, August 31, 2009

Liu, X. and Theil, E.C. (2005) Ferritins: Dynamic management of biological iron and oxygen chemistry. Acc. Chem. Res. 38:167-175.

Liu, X., Kim, K., Leighton, T., Theil, E.C. (2006) Paired Bacillus anthracis Dps (mini-ferritin) have different reactivities with peroxide. J. Biol. Chem. 281: 27827-27835.

Matzapetakis, M., Turano, P., Theil, E.C. and Bertini, I. (2007) 13C-13C NOESY spectra of a 480 kDa protein: solution NMR of ferritin. J. Biomol. NMR, 38: 237-242.

Bermel, W., Bertini, I., Felli, I.C., Matzapetakis, M., Pierattelli, R., Theil, E.C., Turano, P. (2007) A method for Ca direct-detection in protonless NMR. J. Magn. Reson., 188: 301-310.

Liu, X.S., Patterson, L.D., Miller, M.J. and Theil, E.C. (2007) Peptides selected for the protein nanocage pores change the rate of iron recovery from the ferritin mineral. J. Biol. Chem.  282: 31821-31825.

Schwartz, J.K., Liu, X., Tosha, T., Theil, E.C., Solomon, E.I. (2008) Spectroscopic definition of the ferroxidase site in M ferritin: comparison of binuclear substrate vs. cofactor active sites. J. Am. Chem. Soc.: E-pub: June 25.

Hasan MR, Tosha T, Theil EC. Ferritin contains less iron (59Fe) in cells when the protein pores are unfolded by mutation. J Biol Chem. (2008) 283:31394-400.

Tosha T, Hasan MR, Theil EC. The ferritin Fe2 site at the diiron catalytic center controls the reaction with O2 in the rapid mineralization pathway. Proc Natl Acad Sci U S A.(2008) 105:18182-7.

Bellapadrona G, Stefanini S, Zamparelli C, Theil EC, Chiancone E.
J. Iron translocation into and out of listeria innocua Dps and size distribution of the protein-enclosed nanomineral are modulated by the electrostatic gradient at the three-fold "ferritin-like" pores. Biol Chem. 2009 May 20. [Epub ahead of print]

Ferritin DNA and RNA Regulation

Hintze, K. and Theil, E.C. (2005) DNA and mRNA elements with complementary responses to hemin, antioxidant inducers and iron control ferritin-L expression. Proc. Nat’l. Acad. Sci. USA. 102: 15048-15052.

Hintze K.J., Theil, E.C. (2006) Cellular regulation and molecular interactions of the ferritins. Cell Mol. Life Sci. 63: 591-600.

Tibodeau, J.D., Fox, P.M., Ropp, P.A., Theil, E.C., Thorp, H.H. (2006) The up-regulation of ferritin _expression using a small-molecule ligand to the native mRNA. Proc. Nat’l. Acad. Sci. USA 103:253-257.

Walden WE, Selezneva AI, Dupuy J, Volbeda A, Fontecilla-Camps JC, Theil EC, Volz K. Structure of dual function iron regulatory protein 1 complexed with ferritin IRE-RNA. Science. 2006;314: 1903-1908.

Leipuviene, R. and Theil, E.C. (2007) The family of iron responsive RNA structures (IRE) regulated by changes in cellular iron and oxygen. Cell Mol. Life Sci., 64: 2945-2955.

Hintze, K.J., Katoh, Y., Igarashi, K. and Theil, E.C. (2007) Bach1 repression of ferritin and thioredoxin reductase1 is heme-sensitive in cells and in vitro, and coordinates expression with heme oxygenase1, b-globin and NADP(H) quinone (oxido)reductase1. J. Biol. Chem. 282: 34365-34371.

Outten FW, Theil EC. Iron-based Redox Switches in Biology.Antioxid Redox Signal. 2008 Nov 20. [Epub ahead of print]

Medicine/Nutrition

Lonnerdal, B., Bryant, A., Liu, X., Theil, E.C. (2006) Iron absorption from soybean ferritin in nonanemic women. Am. J. Clin. Nutr. 83:103-107

Jenkins, Z.A., Hagar, W., Bowlus, C.L., Johansson, H.E., Harmatz, P., Vichinsky, E.P. and Theil, E.C. (2007) Iron homeostasis during transfusional iron overload in β-thalassemia and sickle cell disease: changes in iron regulatory protein and ferritin expression. Pediatr. Hematol. Oncol. 24: 237-243.

San Martin, C.D., Garri, C., Pizarro, F., Walter, T., Theil, E.C. and Nunez, M.T. (2008) Caco-2 intestinal epithelial cells absorb soybean ferritin by mu2 (AP2)-dependent endocytosis. J. Nutr.138:659-666.

revised: Tuesday, January 19, 2010 4:11 PM