Education
B.S., Cornell University
Ph.D., Columbia University

Email: etheil@chori.org
Phone: 510-450-7670
Fax: 510-597-7131

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Selected Publications 2006-2014
Selected publications from a list of more than 185 published articles.
Click on Hyperlink to view / download articles

Protein nanocages

Theil EC, Turano P, Ghini V, Allegrozzi M, and Bernacchioni C. (2014) Coordinating subdomains of ferritin protein cages with catalysis and biomineralization viewed from the C 4 cage axes. J Biol Inorg Chem. Feb 7. [Epub ahead of print] PMID: 24504941

Theil EC, Behera RK, and Tosha T. (2013) Ferritins for Chemistry and for Life. Coord Chem Rev. 257(2):579-586. PMCID: PMC3587046

Dehner C, Morales-Soto N, Behera RK, Shrout J, Theil EC, Maurice PA, and Dubois JL. (2013) Ferritin and ferrihydrite nanoparticles as iron sources for Pseudomonas aeruginosa. J Biol Inorg Chem. 18(3):371-81. PMCID: PMC3679188

Tosha T, Behera RK, and Theil EC. (2012) Ferritin Ion Channel Disorder Inhibits Fe(II)/O(2) Reactivity at Distant Sites. Inorg Chem. 51(21):11406-11. PMCID: PMC3508004

Bertini I, Lalli D, Mangani S, Pozzi C, Rosa C, Theil EC, and Turano P. (2012) Structural insights into the ferroxidase site of ferritins from higher eukaryotes. J Am Chem Soc. 134(14):6169-76. Epub 2012 Mar 28. [PubMed - in process]

Tosha T, Behera RK, Ng HL, Bhattasali O, Alber T, and Theil EC. (2012) Ferritin Protein Nanocage Ion Channels: Gating By N-Terminal Extensions. J Biol Chem. 287(16):13016-25. Epub 2012 Feb 23. PMCID: PMC3339931

Haldar S, Bevers LE, Tosha T, and Theil EC. (2011) Moving Iron through ferritin protein nanocages depends on residues throughout each four α-helix bundle subunit. J Biol Chem. 286(29):25620-7. PMCID: PMC3138320

Theil EC. (2011) Ferritin protein nanocages use ion channels, catalytic sites, and nucleation channels to manage iron/oxygen chemistry. Curr Opin Chem Biol. 15(2):304-11. PMCID:PMC3074017

Salgado JC, Olivera-Nappa A, Gerdtzen ZP, Tapia V, Theil EC, Conca C, and Nuñez MT. (2010) Mathematical modeling of the dynamic storage of iron in ferritin. BMC Syst Biol. 4:147. PMCID: PMC2992510

Schwartz JK, Liu XS, Tosha T, Diebold A, Theil EC, and Solomon EI. (2010) CD and MCD spectroscopic studies of the two Dps miniferritin proteins from Bacillus anthracis: role of O2 and H2O2 substrates in reactivity of the diiron catalytic centers. Biochemistry. 49(49):10516-25. PMID: 21028901

Tosha T, Ng HL, Bhattasali O, Alber T, and Theil EC (2010) Moving metal ions through ferritin-protein nanocages from three-fold pores to catalytic sites. J Am Chem Soc. 132(41):14562-9. PMID: 20866049

Ferritin DNA and RNA Regulation

Khan MA, Ma J, Walden WE, Merrick WC, Theil EC, and Goss DJ. (2014) Rapid kinetics of iron responsive element (IRE) RNA/iron regulatory protein 1 and IRE-RNA/eIF4F complexes respond differently to metal ions. Nucleic Acids Res. Apr 11. [Epub ahead of print]

Theil EC and Westhof E. (2011) New dimensions of RNA in molecular recognition and catalysis. Acc Chem Res. 44(12):1255-6.

Goss DJ and Theil EC. (2011) Iron responsive mRNAs: a family of Fe2+ sensitive riboregulators. Acc Chem Res. 2011 Dec 20;44(12):1320-8. PMCID: PMC3243817

Holcomb DR, Ropp PA, Theil EC, and Thorp HH. (2010) Nature of guanine oxidation in RNA via the flash-quench technique versus direct oxidation by a metal oxo complex. Inorg Chem. 49(3):786-95. PMCID:PMC2812480

Outten FW and Theil EC (2009) Iron-based redox switches in biology. Antioxid Redox Signal. 11(5):1029-46. Review. PMID:19021503

Khan MA, Walden WE, Goss DJ, and Theil EC. (2009) Direct Fe2+ Sensing by Iron Responsive Messenger RNA/repressor Complexes Weakens Binding. J. Biol. Chem. 284(44):30122-8. PMCID:PMC2781567

Hintze KJ, Katoh Y, Igarashi K, and Theil EC. (2007) Bach1 repression of ferritin and thioredoxin reductase1 is heme-sensitive in cells and in vitro, and coordinates expression with heme oxygenase1, b-globin and NADP(H) quinone (oxido)reductase1. J. Biol. Chem. 282: 34365-34371.

Walden WE, Selezneva AI, Dupuy J, Volbeda A, Fontecilla-Camps JC, Theil EC, and Volz K. (2006) Structure of dual function iron regulatory protein 1 complexed with ferritin IRE-RNA. Science. 314: 1903-1908.

Medicine/Nutrition

Theil EC, Chen H, Miranda C, Janser H, Elsenhans B, Núñez MT, Pizarro F, and Schümann K. (2012) Absorption of iron from ferritin is independent of heme iron and ferrous salts in women and rat intestinal segments. J Nutr.142(3):478-83. PMCID: PMC3278266

Theil, EC. (2011) Iron Homeostasis and Nutritional Iron Deficiency. J Nutr.141(4):724S-8S. PMCID: PMC3056584

Theil EC. (2010) Ferritin iron minerals are chelator targets, antioxidants, and coated, dietary iron. Ann N Y Acad Sci. 1202:197-204. PMID: 20712793

Theil EC. (2009) Mining ferritin iron: 2 pathways. Blood. 114(20):4325-6. No abstract available. PMID: 19965706

San Martin CD, Garri C, Pizarro F, Walter T, Theil EC, and Nunez MT. (2008) Caco-2 intestinal epithelial cells absorb soybean ferritin by mu2 (AP2)-dependent endocytosis. J. Nutr. 138:659-666. PMCID:PMC3065195

Jenkins ZA, Hagar W, Bowlus CL, Johansson HE, Harmatz P, Vichinsky EP, and Theil EC. (2007) Iron homeostasis during transfusional iron overload in β-thalassemia and sickle cell disease: changes in iron regulatory protein and ferritin expression. Pediatr. Hematol. Oncol. 24:237-243.

Revised: Monday, June 2, 2014 3:24 PM

 


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