Education
B.S., Cornell University
Ph.D., Columbia University
Scientists & Staff
Publications

 

Email: etheil@chori.org
Phone: 510-450-7670
Fax: 510-597-7131

 

 

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Selected Publications 2000-2006

Protein

Hwang, J., Krebs, C., Huynh, B.H., Edmondson, D.E. Theil, E.C. and Penner-Hahn, J.E. (2000) A short Fe-Fe distance in peroxodiferric ferritin: Control of Fe substrate versus cofactor decay? Science 287:122-125.

Jin, W., Takagi, H., Pancorbo, N.M. and Theil, E.C. (2001) "Opening" the ferritin pore for iron release by mutation of conserved amino acids at inter-helix and loop sites. Biochemistry. 40:7525-7532.

Liu, X., Jin, W. and Theil, E.C. (2003) Opening protein pores with chaotropes enhances Fe reduction and chelation of Fe from the ferritin biomineral. Proc. Nat'l. Acad. Sci. USA 100:3653-3658.

Liu, X. and Theil, E.C. (2005) Ferritins: Dynamic management of biological iron and oxygen chemistry. Acc. Chem. Res. 38:167-175.

Matzapetakis, M., Turano, P., Theil, E.C. and Bertini, I. (2007) 13C-13C NOESY spectra of a 480 kDa protein: solution NMR of ferritin. J. Biomol. NMR, 38: 237-242.

Liu, X.S., Patterson, L.D., Miller, M.J. and Theil, E.C. (2007) Peptides selected for the protein nanocage pores change the rate of iron recovery from the ferritin mineral. J. Biol. Chem.  282: 31821-31825.

Ferritin DNA and RNA Regulation

Theil, E.C. and Eisenstein, R.S. (2000) Combinatorial mRNA regulation: Iron regulatory proteins and iso-iron responsive elements (iso-IREs). J. Biol. Chem. 275: 40659-40662.

Ke, Y. and Theil, E.C. (2002) An mRNA loop/bulge in the ferritin iron responsive element (IRE) formed in vivo, and detected by radical probing with Cu-phen and protein (IRP) footprinting. J. Biol. Chem. 288:2373-2376.

Erlitzki, R., Long, J. and Theil, E. C. (2002) Multiple, conserved iron-responsive elements in the 3'-untranslated region of transferrin receptor mRNA enhance binding of iron regulatory protein 2. J. Biol. Chem. 277:42579-42587.

Tibodeau, J.D., Fox, P.M., Ropp, P.A., Theil, E.C., Thorp, H.H. (2006) The up-regulation of ferritin _expression using a small-molecule ligand to the native mRNA. Proc. Nat’l. Acad. Sci. USA 103:253-257.

Walden WE, Selezneva AI, Dupuy J, Volbeda A, Fontecilla-Camps JC, Theil EC, Volz K. Structure of dual function iron regulatory protein 1 complexed with ferritin IRE-RNA. Science. 2006;314: 1903-1908.

Leipuviene, R. and Theil, E.C. (2007) The family of iron responsive RNA structures (IRE) regulated by changes in cellular iron and oxygen. Cell Mol. Life Sci., 64: 2945-2955.

Hintze, K.J., Katoh, Y., Igarashi, K. and Theil, E.C. (2007) Bach1 repression of ferritin and thioredoxin reductase1 is heme-sensitive in cells and in vitro, and coordinates expression with heme oxygenase1, b-globin and NADP(H) quinone (oxido)reductase1. J. Biol. Chem. 282: 34365-34371.

Medicine/Nutrition

Murray-Kolb, L. E., Welch, R., Theil, E. C., and Beard, J. L. (2003) Women with low iron stores absorb iron from soybeans. Amer. J. Clin. Nutr. 77:180-184.

Theil, E.C. (2004) Iron, ferritin and nutrition. Annu. Rev. Nutr. 24:327-343.

Davila-Hicks, P., Theil, E.C. and Lonnerdal, B.L. (2004) Iron in ferritin or in salts (ferrous sulfate) is equally unavailable in American women. Am. J. Clin. Nutr. 80:936-940.

Lonnerdal, B., Bryant, A., Liu, X., Theil, E.C. (2006) Iron absorption from soybean ferritin in nonanemic women. Am. J. Clin. Nutr. 83:103-107

Jenkins, Z.A., Hagar, W., Bowlus, C.L., Johansson, H.E., Harmatz, P., Vichinsky, E.P. and Theil, E.C. (2007) Iron homeostasis during transfusional iron overload in β-thalassemia and sickle cell disease: changes in iron regulatory protein and ferritin expression. Pediatr. Hematol. Oncol. 24: 237-243.

San Martin, C.D., Garri, C., Pizarro, F., Walter, T., Theil, E.C. and Nunez, M.T. (2008) Caco-2 intestinal epithelial cells absorb soybean ferritin by mu2 (AP2)-dependent endocytosis. J. Nutr.138:659-666.

 

 

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