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A hallmark of aging is a significantly increased vulnerability to environmental and oxidative stresses. This vulnerability represents one of the most important underlying age-related changes that predisposes individuals to chronic pathologies (e.g., cardiovascular, neurological diseases, and cancer). It is known the increased vulnerability to age-related illneses is due partly to a decline in cellular stress response mechanisms but the reasons for this decline is likely multifactorial. Our lab is actively engaged in the exploration of the role of decay of endoplasmic reticulum-dependent protein processing in this decline.

In addition, we are also investigating oxidative stress and its relation to chronic illnesses, and have developed a new technique for the detection and quantification of oxidation states of a comprehensive panel of aminothiols. We are currently utilizing the potential clinical applications of this method as a diagnostic tool in various diseases like autism, sickle cell disease, thalassemia, polycystic ovarian syndrome and childhood obesity.


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