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Dr. Styles is a pediatric hematologist/oncologist whose research interests are in translational and clinical research. As a national leader in sickle cell disease (SCD) research, Dr. Styles has been the principal investigator on several national, multiinstitutional clinical trials in SCD. Working with CHORI Senior Scientist Frans Kuypers, PhD, she identified secretory phospholipase A2 as playing a major role in acute chest syndrome in sickle cell disease. This work culminated in the just completed multiinstitution PROACTIVE trial as part of the NIH SCD Clinical Research Network.

Other recent areas of investigation have included investigating a role for arginine in preventing pain crisis in SCD and the use of adhesion receptor inhibitors in treating acute pain episodes. Current projects involve assessing gene expression changes induced by transfusion in SCD, the use of statins to reduce inflammation in sickle cell disease and the potential use of a platelet inhibitor to prevent pain crisis.

Lastly, Dr. Styles is exploring the important area of minority health care disparities in pediatric patients with chronic disease. Dr. Styles has a keen interest in mentoring young investigators and was awarded one of only two sickle cell disease NIH K24 Mentoring grants from the NIH in recognition of her work in career development of young investigators. She is an important resource for scientists at CHORI who want to translate their findings from the bench to the bedside.




Revised: Wednesday, October 10, 2012 10:34 AM


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