JULIE D. SABA, MD, PHD
Dr. Saba's Laboratory
Pediatric Malignancies
Colon Cancer
Muscular Dystrophy
T Cell Trafficking
S1P Lyase Deficiency Syndrome
Scientists & Staff
Publications
Videos

Email
Phone: 510-450-7690

CHORI Staff Directory
CHORI Intranet
CHORI News


SELECTED PUBLICATIONS

Lovric S, Goncalves S, Gee YH, Oskouian B, et al. SGPL1 mutations cause nephrosis with ichthyosis and adrenal insufficiency. J Clin Invest (in press). Note: JD Saba is co-corresponding author on this publication.

Mitroi DN, Deutschmann AU, Raucamp M, Karunakaran I, Glebov K, Hans M, Walter J, Saba J, Gräler M, Ehninger D, Sopova E, Shupliakov O, Swandulla D, van Echten-Deckert G.Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin-proteasome mediated mechanism. Sci Rep. 6:37064, 2016.

Kumar A, Zamora-Pineda J, Suh JH, Zhang M, Saba JD.  Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress. J Exp Med. 213(12):2773-2791, 2016.

Degagné E, Bandhuvula P, Kumar A, Pandurangan A, Eltanawy A, Zhang M, Ahmedi Y, Yoshinaga Y, Nefedov M, de Young P, Fong LG, Young SG, Saba JD. Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated miRNAs. J Clin Invest 124(12):5368-5384, 2014.

de la Garza-Rodea AS, Baldwin D, Oskouian B, Place R, Bandhuvula P, Kumar A, Saba JD. S1P lyase regulates myogenic differentiation via S1PR-mediated effects on myogenic microRNA expression. FASEB J. 28(1):506-19, 2014.

Park K, Elias PM, Shin KO, Lee YM, Hupe M, Borkowski AW, Gallo RL, Saba JD, Holleran WM, Uchida Y. A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity. Mol Cell Biol. 33(4):752-62, 2013.

Kumar A, Pandurangan A, Lu F, Fyrst H, Zhang M, Byun HS, Bittman R, Saba JD. Chemopreventive sphingadienes downregulate Wnt signaling in human colon cancer cells and intestinal tissues of ApcMin/+ mice. Carcinogenesis. 33:1726-35, 2012.

McElwain MA, Ko DC, Gordon MD, Fyrst H, Saba JD, Nusse R. A suppressor/enhancer screen in Drosophila reveals a role for Wnt-mediated lipid metabolism in primordial germ cell migration. PLoS One. 6(11):e26993, 2011.

Fyrst H, Saba JD. An update on sphingosine-1-phosphate and other sphingolipid mediators. Nature Chemical Biology 6:489-497, 2010. PMCID: PMC3001344.

Fyrst H, Oskouian B, Bandhuvula P, Gong Y, Byun HS, Bittman R, Lee AR, Saba JD. Natural sphingadienes inhibit Akt-dependent signaling and prevent intestinal tumorigenesis. Cancer Research 69:9457-9464, 2009.

Oskouian B, Sooriyakumaran P, Borowsky AD, Crans A, Dillard-Telm L, Tam YY, Bandhuvula P, Saba JD. Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is downregulated in colon cancer. Proc Natl Acad Sci USA 103: 17384-9, 2006.

Jiang Q, Wong J, Fyrst H, Saba JD, Ames BN. gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis. Proc Ntl Acad Sci USA 101:17825-30, 2004.

Herr DR, Fyrst H, Phan V, Heinecke K, Georges R, Harris GL, Saba JD. Sply regulation of sphingolipid signaling molecules is essential for Drosophila development. Development 11:2443-53, 2003.

Zhou JH, Saba JD. Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast. Biochem Biophys Res Commun 242:502-507, 1998.

Saba JD, Nara F, Bielawska A, Garrett S, Hannun YA. The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. J Biol Chem 272, No. 42:26087-91, 1997.

Revised: December 1, 2016 2:51 PM

BUCSF

 

© 2005 Children's Hospital Oakland Research Institute
5700 Martin Luther King Jr Way • Oakland, California 94609
Phone 510-450-7600 • Fax 510-450-7910
Site MapDisclaimer