RECENT PUBLICATIONS

Sphingolipids in Development

Zhang K, Pompey JM, Hsu FF, Turk J, Bandhuvula P, Saba JD, Beverly SM. Redirection of sphingolipid metabolism towards de novo synthesis of ethanolamine in Leishmania. EMBO J 26:1094-104, 2007.

Saba JD. Lysophospholipids in development: miles apart and edging in. J Cell Biochem 92:967-92, 2004.

Oskouian B and Saba JD. Death and taxis: what non-mammalian models tell us about sphingosine 1-phosphate. Semin Cell Dev Biol 15:529-40, 2004.

Herr DR, Fyrst H, Creason M, Phan V, Saba JD and Harris GL. Characterization of the Drosophila sphingosine kinases and requirement for Sk2 in normal reproductive function, J Biol Chem 279:12685-12694, 2004.

Fyrst H, Herr DR, Harris GL and Saba JD. Characterization of free endogenous C14 and C16 sphingoid bases from Drosophila melanogaster, J Lipid Res 45:54-62, 2004.

Mendel J, Heinecke K, Fyrst H and Saba JD. Sphingosine phosphate lyase expression is essential for normal development in Caenorhabditis elegans, J Biol Chem 278:22341-22349, 2003.

Herr DR, Fyrst H, Phan V, Heinecke K, Georges R, Harris GL and Saba JD. Sply regulation of sphingo-lipid signaling molecules is essential for Drosophila development. Development 11:2443-2453, 2003.

Zhou JH and Saba JD. Identification of the first mammalian sphingosine phosphatelyase gene and its functional expression in yeast. Biochem Biophys Res Commun 242:502-507, 1998.

Sphingolipids in Immunity and Cancer

Oskouian B and Saba JD. Sphingosine-1-phosphate metabolism and intestinal tumorigenesis: lipid signaling strikes again. Cell Cycle 6:522-7, 2007.

Bandhuvula P and Saba JD. Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren. Trends in Molecular Medicine (in press).

Oskouian B, Sooriyakumaran P, Tam YY, Bandhuvula P and Saba JD. Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is downregulated in colon cancer. Proc Natl Acad Sci USA 103: 17384-9, 2006.

Kitano M, Hla T, Sekiguchi M, Kawahito Y, Yoshimura R, Miyazawa K, Iwasaki T, Sano H, Saba JD, Tam YY. Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression. Arthritis Rheum 54:742-53, 2006.

Kohno M, Momoi M, Oo ML, Paik JH, Lee YM, Venkataraman K, Ai Y, Ristimaki AP, Fyrst H, Sano H, Rosenberg D, Saba JD, Proia RL and Hla T. Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol Cell Biol 19:7211-23, 2006.

Bandhuvula P, Tam Y, Oskouian B, Saba JD. The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity. J Biol Chem 280:33697-700, 2005.

Oskouian B, Mendel J, Shocron E, Lee Jr. MA, Fyrst H and Saba JD. Regulation of sphingosine-1-phosphate lyase gene expression by members of the GATA family of transcription factors. J Biol Chem 280: 18403-10, 2005.

Jiang Q, Wong J, Fyrst H, Saba JD and Ames BN. Gamma-tocopherol and combinations of vitamin E forms induce cell death in human prostate cancer cells by disturbing de novo synthesis of sphingolipids. Proc Natl Acad Sci USA 101:17825-30, 2004.

Saba JD and Hla T. The point-counterpoint of sphingosine 1-phosphate metabolism. Circulation Res 94:724-34, 2004.

Reiss U, Oskouian B, Zhou J, Gupta V, Kelly S, Wang E, Sooriyakumaran P, Merrill H Jr and Saba JD. Sphingosine phosphate lyase enhances stress-induced ceramide generation and apoptosis. J Biol Chem. 279:1281-90, 2004.

Saba JD, Obeid LM, Hannun YA. Ceramide: an intracellular mediator of apoptosis and growth suppression. Phil Trans R Soc Lond 351:233-244, 1996.

Sphingolipids and Lipid Metabolism in Saccharomyces cerevisiae

Birchwood CJ, Saba JD, Dickson RC and Cunningham KW. Calcium influx and signaling in yeast stimulated by intracellular sphingosine-1-phosphate accumulation, J Biol Chem 276(15):11712-11718, 2001.

Kim S, Fyrst H and Saba JD. Accumulation of long chain phosphorylated sphingoid bases results in cell growth inhibition in S. cerevisiae, Genetics 156:1519-1529, 2000.

Caligan TB, Peters K, Ou J, Wang E, Saba J and Merrill, AH Jr. A high-performance liquid chromatographic method to measure sphingosine-1-phosphate and related compounds from sphingosine kinase assays and other biological samples,Anal Biochem 281:36-44, 2000.

Mao C, Saba JD and Obeid LM. The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses, Biochem J. 342:667-675,1999.

Fyrst H, Oskouian B, Kuypers F and Saba JD. The PLB2 gene of Saccharomyces cerevisiae confers resistance to lysophosphatidylcholine and encodes a phospholipase B/lysophospholipase, Biochemistry 38 (18):5864-5871, 1999
Gottlieb D, Heideman W, and Saba JD. The DPL1 gene is involved in mediating the response to nutrient deprivation in Saccharomyces cerevisiae, Mol Cell Biol Res Commun. 1:66-71, 1999.

Oskouian, B and Saba JD. YAP1 confers resistance to the fatty acid synthase inhibitor cerulenin through transporters of both the ATP binding cassette and major facilitator superfamilies in Saccharomyces cerevisiae, Mol. Gen. Gen. 261(2):346-53, 1999.

Lanterman M and Saba JD. Characterization of sphingosine kinase activity in S. cerevisiae, and isolation of sphingosine kinase deficient mutants, Biochem J 332(Pt. 2):525-531, 1998.

Saba JD, Garrett SD, Bielawska A, Nara F, Hannun YA. The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase, J. Biol. Chem 272, No.42:26087-91, 1997.

Umbilical Cord Blood Banking

Reed W, Smith R, Dekovic F, Lee JY, Saba JD, Trachtenberg E, Walters MC, Epstein J, Haaz S, and Lubin BH. Comprehensive banking of sibling donor cord blood for children with malignant and non-malignant disease. Blood 101(1):351-7,2003.

Lubin B, Trachtenberg E, Saba J, Lee JY and Reed W. Banking of sibling donor cord blood for children with malignant and non-malignant disease. In: Cord Blood Banking, McCurdy P, ed. Marcel Dekker, New York, NY, 2003.

Revised: April 10, 2007 10:38 AM