JULIE D. SABA, MD, PHD
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Pediatric Malignancies

Our laboratory is investigating the impact of S1P and other bioactive sphingolipids in pediatric cancer. We have found that plant-type sphingolipids called sphingadienes are capable of inhibiting the growth of neuroblastoma cells in culture and can reduce their ability to form tumors. We have also recently discovered a novel  S1P-regulated gene that has a powerful effect on the growth of cancer cells derived from highly malignant pediatric tumors including neuroblastoma and rhabdomyosarcoma. By studying this gene and its function in normal and malignant cells, we hope to identify the mechanism by which it promotes the growth of cancer cells and facilitates their ability to form tumors. This information could lead to the development of new therapeutic strategies targeting S1P and its downstream cancer-related genes to treat pediatric malignancies.

(below: classical rosette pattern of neuroblastoma tumor. Courtesy Elaine Cham, MD)

Revised: December 1, 2016 3:31 PM

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