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James Riddel, RN, MS, is a pediatric nurse practitioner at CHO, and an assistant clinical professor and doctoral student at UCSF. His research interests focus on Von Willebrand Disease (vWD) type 1, the most common for vWD, which accounts for as much as 80 percent of reported cases. With prevalence estimates as high as 1.6% in the general population, upwards of 4.5 million Americans may be affected. Unfortunately, vWD type 1 is also the most difficult type to diagnose, leading to greater patient distress and increased cost. Despite continued progress in defining the genetic alterations responsible for types 2 and 3, identification of the genetic determinants of vWD type 1 remains elusive.
Mr. Riddel, under the mentorship of Bradley Aouizerat, Ph.D, a quantitative genetist with UCSF, is the co-investigator of a study funded by the National Hemophilia Foundation aimed at identifying and characterizing common polymorphisms within the von Willebrand factor (vwF) gene that account for a sufficient portion of variation in vWF levels to be clinically useful in the diagnosis and management of vWD type 1.
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