Recent Publications

Noble, J. A., White, A. M., Lazzeroni, L. C., Valdes, A. M., Mirel, D. B., Reynolds, R., Grupe, A., Aud, D., Peltz, G., and Erlich, H. A. (2003b). A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes. Diabetes 52, 1579-1582

Noble JA, Valdes AM, Bugawan TL, Apple RJ, Thomson G, Erlich HA. The HLA class 1 A locus affects susceptibility to Type 1 diabetes. Human Immunology 2002; 63:657-64.

Single RM, Meyer D, Hollenbach JA, Nelson MP, Noble JA, Erlich HA, Thomson G. Haplotype frequency estimation in patient populations: The effect of departures from Hardy-Weinberg proportions and collapsing over a locus in the HLA region. Genet Epidemiol 2002; 22:186-95.

Greenbaum CJ, Gaur LK, Noble JA. ICA+ relatives with DQA1*0102/DQB1*0602 have expected 0602 sequence and DR types. J Autoimmunity 2002; 18:67-70.
Park YS, She JX, Noble JA, Erlich HA, Eisenbarth GS. Transracial evidence for the influence of the homologous HLA DR-DQ haplotype on transmission of HLA DR4 haplotypes to diabetic children. Tissue Antigens 2001; 57:185-191.

Valdes AM, Noble JA, Genin E, Clerget-Darpoux F, Erlich HA, Thomson G. Modeling of HLA class II susceptibility to Type I diabetes reveals an effect associated with DPB1. Genet Epidemiol 2001; 21:212-23.

Zeidler A, Raffel LJ, Costin G, et al. Autoantibodies and human leucocyte antigen class II in first-degree family members of Mexican-American type 1 diabetic patients. J Clin Endocrinol Metab 2001; 86:4957-62.

Noble JA, Valdes AM, Thomson G, Erlich HA. The HLA class II locus DPB1 can influence susceptibility to type 1 diabetes. Diabetes 2000; 49:121-5.

Park Y, She JX, Wang CY, et al. Common susceptibility and transmission pattern of human leukocyte antigen DRB1-DQB1 haplotypes to Korean and Caucasian patients with type 1 diabetes. J Clin Endocrinol Metab 2000; 85:4538-42.

Redondo MJ, Kawasaki E, Mulgrew CL, et al. DR- and DQ-associated protection from type 1A diabetes: comparison of DRB1*1401 and DQA1*0102-DQB1*0602*. J Clin Endocrinol Metab 2000; 85:3793-7.

Herman AE, Tisch RM, Patel SD, et al. Determination of glutamic acid decarboxylase 65 peptides presented by the type I diabetes-associated HLA-DQ8 class II molecule identifies an immunogenic peptide motif. J Immunol 1999; 163:6275-82.

Pugliese A, Kawasaki E, Zeller M, et al. Sequence analysis of the diabetes-protective human leukocyte antigen-DQB1*0602 allele in unaffected, islet cell antibody-positive first degree relatives and in rare patients with type 1 diabetes. J Clin Endocrinol Metab 1999; 84:1722-8.

Valdes AM, Thomson G, Erlich HA, Noble JA. Association between type 1 diabetes age of onset and HLA among sibling pairs. Diabetes 1999; 48:1658-61.
Yu L, Brewer KW, Gates S, et al. DRB1*04 and DQ alleles: expression of 21-hydroxylase autoantibodies and risk of progression to Addison's disease. J Clin Endocrinol Metab 1999; 84:328-35.

Patents
6,204,020
Ladner MB, Van Arsdell JN, Martin GA, Kawasaki ES, Coyne MY, Halenback RF, Koths, KA. DNA encoding N.gradient.2 CSF-1 (short form) and carboxy truncated fragment thereof. March 20, 2001

6,156,300
Ladner MB, Noble JA, Martin GA, Kawasaki ES, Coyne MY, Halenback RF, Koths, KA. Point mutants of N.gradient.2 CSF-1 and carboxy truncated fragments thereof. December 5, 2000

6,146,851
Ladner MB, Van Arsdell JN, Martin GA, Kawasaki ES, Coyne MY, Halenback RF, Koths, KA. DNA encoding NV2 (long form) and carboxy truncated fragments thereof. November 14, 2000

6,117,422
Ladner MB, Noble JA, Martin GA, Kawasaki ES, Coyne MY, Halenback RF, Koths, KA. N.gradient.2-CSF-1(long form) and carboxy truncated fragments thereof. September 12, 2000.

6,103,224
Ladner MB, Van Arsdell JN, Martin GA, Kawasaki ES, Coyne MY, Halenback RF, Koths, KA. N.gradient.2 CSF-1 (short form) and carboxy truncated fragments thereof. August 15, 2000.

5,681,719
Ladner MB, Noble JA, Martin GA, Kawasaki ES, Coyne MY, Halenback RF, Koths, KA. DNA encoding N- and C- terminally truncated colony stimulating factor-1 variants. October 28, 1997.

5,672,343
Ladner MB, Noble JA, Martin GA, Kawasaki ES, Coyne MY, Halenback RF, Koths, KA. N- 3 deletion mutants of the long form of CSF-1. September 30, 1997.

5,643,563
Ladner MB, Noble JA, Martin GA, Kawasaki ES, Coyne MY, Halenback RF, Koths, KA. N-.gradient.3 deletion mutants of the short form of CSF-1. July 1, 1997.

5,573,930
Ladner MB, Noble JA, Martin GA, Kawasaki ES, Coyne MY, Halenback RF, Koths, DNA encoding various forms of colony stimulating factor-1. November 12, 1996.