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There are four main areas of research in Vas’ group; we examine: (i) structure-function relationships in apoE using fluorescence and other biophysical approaches, (ii) the role of apoE in cholesterol transport and metabolism at the neurovascular junction; specifically, we investigate the role of apoE isoforms in the amyloidogenesis process in Alzheimer’s disease and CAA at the molecular and cellular levels, (iii) the use of apoE-containing reconstituted HDL as a nanovehicle to transport bioflavonoids in the blood, and lastly, (iv) the effect of second hand smoke exposure on the structure and function of apoE with parallel in vivo and in vitro studies.

Revised: Thursday, January 26, 2012 9:14 AM


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