Email: vnarayan@chori.org

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Selected Publications (2007-Present)

  1. Tran, T. N., Kim, S. H., Gallo, C., Amaya, M., Kyees, J. and Narayanaswami, V. (2013) Biochemical and Biophysical Characterization of Recombinant Rat Apolipoprotein E: Similarities to Human Apolipoprotein E3. Arch. Biochem. Biophys. 259, 18-25 (PMCID: PMC3543869).

  2. Zheng, Y., Kim, S. H., Patel, A. B., Narayanaswami, V, Iavarone, A. T., Hura, G. L. & Bielicki, J. K. (2012) The positional specificity of EXXK motifs within an amphipathic alpha-helix dictates preferential lysine modification by acrolein: Implications for the design of high-density lipoprotein mimetic peptides. Biochemistry 51, 6400-6412 (PMID: 22800301).

  3. Bains, G., Patel, A. B. and Narayanaswami, V. (2011) Pyrene: A probe to study protein conformation and conformational changes. Molecules 16, 7909-7935. Download

  4. Zheng, Y., Kim, S. H., Patel, A. B., Narayanaswami, V., Iavarone, A. T., Hura, G. L. and John K. Bielicki (2012) Positional specificity of EXXK motifs within an amphipathic α-helix dictates preferential lysine modification by acrolein: Implications for the design of HDL mimetic peptides. Biochemistry (DOI:10.1021/bi300626g).

  5. Jairam, V., Uchida, K & Narayanaswami, V. (2012) Pathophysiology of
    Lipoprotein Oxidation In Lipoproteins – Role in Health and Diseases
    (Eds. S. Frank and G. Kostner) ISBN 980-953-307-145-4, InTech,
    Croatia, pp 383-408.

  6. Bains, G. K., Kim, S. H., Sorin, E. J. and Narayanaswami, V. (2012) Extent of pyrene excimer fluorescence emission is a reflector of distance and flexibility: Analysis of the segment linking the LDL Receptor-binding and tetramerization domains of apolipoprotein E3. Biochemistry (DOI: 10.1021/bi3005285).

  7. Zheng, Y., Patel, A. B., Narayanaswami, V., Hura, G. L., Hang, B., Bielicki, J. K. (2011) HDL Mimetic Peptide ATI-5261 Forms an Oligomeric Assembly in Solution That Dissociates to Monomers upon Dilution. Biochemistry. 50(19):4068-76. PMCID: PMC3100537 Download

  8. Khumsupan, P., Ramirez, R., Khumsupan, D. and Narayanaswami, V. (2011) Apolipoprotein E LDL receptor-binding domain-containing high-density lipoprotein: A nanovehicle to transport curcumin, an antioxidant and anti-amyloid bioflavonoid. Biochim Biophys Acta 1808, 352-359. PMCID: PMC2997894 Download

  9. Hauser, P. S., Narayanaswami, V. and Ryan, R. O. (2011) Review: Apolipoprotein E: From lipid transport to neurobiology. Prog. Lipid Res. 50, 62-74. PMCID: PMC3022415 Download

  10. Bielicki, J. K., Zhang, H., Cortez, Y., Narayanaswami, V., Patel, A. B., Johansson, J. and Azhar, S. (2010) A new HDL mimetic peptide that stimulates cellular cholesterol efflux with high efficiency greatly reduces atherosclerosis in mice. J. Lipid Res. 51, 1496-1503. PMCID: PMC3035513 Download

  11. Patel, A. B., Khumsupan, P. and Narayanaswami, V. (2010) Pyrene Fluorescence Analysis Offers New Insights into the Conformation of the Lipoprotein-Binding Domain of Human Apolipoprotein E. Biochemistry 49, 1766-1775. Download

  12. Crutcher, K. A., Lilley, H. N., Anthony, S. R., Zhou, W. and Narayanaswami, V. (2010) Full-length apolipoprotein E protects against the neurotoxicity of an apoE-related peptide. Brain Research 1306, 106-115. PMCID: PMC2794278 Download

  13. Narayanaswami, V., Kiss, R. S. and Weers, P. M. (2010) Review: The helix bundle: a reversible lipid binding motif. Comparative Biochem. Physiol. A Mol. Integr. Physiol. 155, 123-133. PMCID: PMC2808439. Download

  14. Cerf, E., Sarroukh, R., Tamamizu-Kato, S., Derclaye, S., Dufrêne, Y., Narayanaswami, V., Goormaghtigh, E., Ruysschaert, J.-M. and Raussens, V. (2009) Anti-parallel b-sheet - A signature structure of the oligomeric amyloid-beta peptide. Biochemical J. 421, 415-423. Download

  15. de Chaves, E.P. and Narayanaswami, V. (2008) Review: Apolipoprotein E and Cholesterol Transport in Aging and Disease. Future Lipidology 3, 505-530. PMCID: PMC2600507. Download

  16. Tamamizu-Kato, S., Cohen, J. K., Drake, C., Kosaraju, M. G., Drury, J. and , V. (2008) Interaction with amyloid beta peptide compromises the lipid binding function of apolipoprotein E. Biochemistry 47, 5225-5234. Download

  17. Tamamizu-Kato, S., Jairam, V., Wong, J., Uchida, K., Raussens, V., Ruysschaert, J.-M. and Narayanaswami, V. (2007) Acrolein mediates structural modification and functional impairment of apolipoprotein E. Biochemistry 46, 8392-8400. PMCID: PMC2556514. Download

  18. Kim, H., Kothari, S., Patel, A. B., Bielicki, J. K. & Narayanaswami, V. (2014) A Pyrene Based Fluorescence Approach to Study Conformation of Apolipoprotein E3 in Macrophage-generated Nascent High Density Lipoprotein. Biochem. Biophys. Res. Commun. 450, 124-128 (PMCID # PMC4130211)

  19. Tran, N., Kosaraju, M. G., Tamamizu-Kato, S., Akintunde, O., Zheng, Y., Bielicki, J. K., Pinkerton, K, Uchida, K., Lee, Y. Y. & Narayanaswami, V. (2014) Acrolein Modification Impairs Key Functional Features of Rat Apolipoprotein E: Identification of Modified Sites by Mass Spectrometry. Biochemistry 53, 361-375 (PMCID # PMC3937454).

  20. Zheng, Y., Patel, A. B., Narayanaswami, V. & Bielicki, J. K. (2013) Retention of α-helical structure by HDL mimetic peptide ATI-5261 upon extensive dilution represents an important determinant for stimulating ABCA1 cholesterol efflux with high efficiency. Biophys. Res. Commun. 441, 71-76 (PMID # 24129191- PubMed In Process).

Other publications
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?CMD=search&DB=PubMed

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