Marisa Wong Medina, PhD
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PUBLICATIONS (2010-2016)

2016
Theusch E, Kim K, Steven K, Smith JD, Chen Y-D I, Rotter JI, Nickerson DA and Medina MW. Statin-induced expression change of INSIG1 in lymphoblastoid cell lines is correlated with plasma triglyceride statin response in a sex specific-manner. The Pharmacogenomics Journal (in press)

Chibber A, French C, Yee SW, Gamazon E, Theusch E, Qin X, Webb A, Papp A, Wang A, Simmons C, Konkashbaev A, Chaudhry A, Mitchel K, Stryke D, Ferrin T, Weiss S, Kroetz D, Sadee W, Nickerson D, Krauss K, George A, Scheutz E, Medina MW, Cox N, Scherer S, Giacomini K, Brenner SE. Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines. The Pharmcogenomics Journal  (in press)

2015
Luzum JA, Kitzmiller JP, Isackson PJ, Ma C, Medina MW, Dauki AM, Mikulik EB, Ochs-Balcom HM, Vladutiu GD. GATM Polymorphism and the Risk for Statin-Induced Myopathy: Previously reported association not confirmed in case-control analysis of 715 dyslipidemic individuals. Cell Metabolism April 21(4):622-627 PMC4394188

Luzum J, Theusch E, Taylor K, Wang A, Sadee W, Brinkley PF, Krauss RM, Medina MW, Kitzmiller JP. Individual and combined associations of genetic variants in CYP3A4, CYP3A5 and SLCO1B1 with simvastatin and simvastatin acid plasma concentrations.  In press at Journal of Clinical Pharmacology

2014
Kim K, Bolotin E, Theusch E, Huang H, Medina MW*, Krauss RM*. Prediction of LDL cholesterol response to statin using transcriptomic and genetic variation. Genome Biology 15:460*co-corresponding author

Naidoo D, Wu AC, Brilliant MH, Denny J, Ingram C, Kitchner TE, Linneman JG, McGeachie MJ, Roden DM, Shaffer CM, Shah A, Weeke P, Weiss ST, Xu H, Medina MW. A polymorphism in HLA-G modifies statin benefit in asthma. The Pharmacogenomics Journal - advance online publication 30 September 2014; doi: 10.1038/tpj.2014.55

Medina MW*, Bauzon F, Naidoo D, Theusch E, Stevens K, Schilde J, Schubert C, Mangravite LM, Rudel LL, Temel RE, Runz H and Krauss RM. Transmembrane Protein 55B is a Novel Regulator of Cellular Cholesterol Metabolism. Arterioscler Thromb Vasc Biol in press. PMID: 25035345. *corresponding author

Theusch E, Medina MW, Rotter JI and Krauss RM. Ancestry and other genetic associations with plasma PCSK9 response to simvastatin. Pharmacogenetics and Genomics in press

Kitzmiller JP, Talameh JA, Baldassarre D, Krauss RM and Medina MW. CYP3A4*22 and CYP3A5*3 are associated with increased levels of plasma simvastatin concentrations in the Cholesterol and Pharmacogenetics study cohort. Pharmacogenetics and Genomics July 19 [Epub ahead of print]. PMID: 25051018

Brown CC, Havener TM, Medina MW, Krauss RM, McLeod HL and Motsinger-Reif AA. Genome-wide Association and Pharmacological Proling of 29 Anticancer Agents Using Lymphoblastoid Cell Lines. Pharmacogenomics 15(2):137-46. PMC4055088

Bolotin E, Armendariz A, Kim K, Heo S-J, Boffelli D, Tantisera K, Krauss RM and Medina MW. Statin induced changes in gene expression in EBV-transformed and native B-cells. Human Molecular Genetics 23(5):1202-10.PMC3919007

2013
Yu CY, Theusch E, Lo K, Mangravite LM, Naidoo D, Kutilova M and Medina MW.  HNRNPA1 regulates HMGCR alternative splicing and modulates cellular cholesterol metabolism. Human Molecular Genetics. 23(2):319-32. PMC3869353

Mangravite LM*, Engelhardt BE*, Medina MW, Smith JD, Brown CD, Chasman DI, Mecham BH, Howie B, Shim H, Naidoo D, Feng Q, Rieder MJ, Chen Y-D, Rotter JI, Ridker PM, Hopewell JC, Parish S, Armitage J, Collins R, Wilke RA, Nickerson DA, Stephens M and Krauss RM.GATM locus is associated with reduced incidence of statin-induced myopathy. Nature 502(7471):377-80. PMC3933266. *co-first authors

Holzinger ER, Dudek SM, Frase AT, Krauss RM, Medina MW and Ritchie MD.  ATHENA: A tool for meta-dimensional analysis applied to genotypes and gene expression data to predict HDL cholesterol levels. Pacific Symposium on Biocomputing 385-96. PMC3587764

Medina MW* and Krauss RM.  Alternative splicing in regulation of cholesterol homeostasis. Current Opinion in Lipidology 24(2):147-52, PMC2805071 *corresponding author

Gao F, Ihn HE, Medina MW and Krauss RM.  A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function. Human Molecular Genetics 22(7):1424-31. PMC3596853

2012
Brown CC, Havener TM, Medina MW, Krauss RM, McLeod HL and Motsinger-Reif AA. Multivariate methods and software for association mapping in dose-response genome-wide association studies. BioData Mining 5(1):21. PMC3661384

Medina MW*, Theusch E, Naidoo D, Bauzon F, Stevens K, Mangravite L, Kuang YL and Krauss RM*. RHOA is a modulator of the cholesterol lowering effects of statin. Identification of a loci on chromosome 3 associated with statin response. PLoS Genetics 8(11)e1003058. PMC3499361. *co-corresponding authors

Brown C, Havener T, Medina MW, Mangravite L, Krauss RM, McLeod H and Motsinger-Reif A. A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines reveals a clinically relevant association with MGMT. Pharmacogenetics and Genomics 22(11):796-802. PMC3691078

 

2011
Roden DM, Johnson JA, Kimmel S, Krauss RM, Medina MW, Shuldiner A, and Wilke RA. Cardiovascular Pharmacogenomics. Circulation Genetics,109(7):807-20. PMC3201825

Medina MW, Gao F, Naidoo D, Rudel LL, Temel R, McDaniel A, Marshall S and Krauss RM. Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptake. PLoS One, 6(4):e19420 PMC3084847

2010
Medina MW. The relationship between HMGCR genetic variation, alternative splicing, and statin efficacy. Discovery Medicine 9(49):495-9. PMID 20587337

Mangravite LM*, Medina MW*, Ciu J, Smith JD, Rieder MJ, Guo X, Nickerson DA, Rotter JI and Krauss RM. Combined influence of LDLR and HMGCR sequence variation on lipid-lowering response to simvastatin. Arterioscler Thromb Vasc Biol 30(7):1485-92. PMC2909117.  *co-first authors

Medina MW, Sangkuhl K, Klein TE and Altmann RB. PharmGKB: Very Important Pharmacogene--HMGCR. Pharmacogenetics and Genomics 21(2):98-101 PMID 20084049 PMC3098759

 

 

Revised: Tuesday, March 29, 2016 9:12 AM

 

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