National Birth Defects Prevention Study (NBDPS) and the Birth Defects Study to Evaluate Pregnancy Exposures (BD-STEPS):
From 1996-2013, Dr. Lammer served as the clinical geneticist of the California site of the CDC Centers of Birth Defects Research and Prevention (http://www.nbdps.org) The California Center collaborated with eight other U.S. sites to jointly conduct the National Birth Defects Prevention Study (NBDPS), the largest case-control study of birth defects ever undertaken. Each Center enrolled about 300 case and 100 control infants and mothers annually, and archived DNA samples from participants. Thirty different major malformations were eligible for inclusion.
The Birth Defects Study to Evaluate Pregnancy Exposures (BD-STEPS) is a 5-year, CDC-funded multi-center investigation of children born with 17 eligible major malformations (http://www.bdsteps.org). Beginning in 2013, the BD-STEPS program follows in the steps of the NBDPS -- the California Center is based at Stanford University (PIs Drs. Gary Shaw and Suzan Carmichael), while Dr. Lammer is the clinical geneticist and will review the medical records of every eligible California infant to ensure that each meets specified diagnostic eligibility criteria. Like NBDPS, the California Center’s study area for BD-STEPS will be based on mother’s residence within the eight Central Valley counties around Fresno.
Rasmussen SA, Lammer EJ, Shaw GM, Finnell RH, McGehee RE, Gallagher M, Romitti PA, Murray JC and NBDPS. Integration of DNA sample collection into a multi-site birth defects case-control study. Teratology 2002; 66:177-184.
Carmichael SL, Yang W, Roberts E,Kegley SE, Padula AM, English PB, Lammer EJ, Shaw GM. Residential agricultural pesticide exposures and risk of selected congenital heart defects among offspring in the San Joaquin Valley of California. Environmental Res 2014; 135C:133-138.
Skuladottir H, Wilcox A, Ma C, Lammer EJ, Rasmussen S, Werler MM, Shaw GM, Carmichael SC. Corticosteroid use and risk of orofacial clefts. Birth Defects Res 2014; 100(6):499-506.
Botto LS, Panichello JD, Browne ML, Krikov S, Feldkamp ML, Lammer E, Shaw GM, and the National Birth Defects Prevention Study. Congenital heart defects after maternal fever. Am J Obstet Gynecol 2013; Nov 1. pii: S0002-9378(13)01990-X.
Sanchez-Lara PA, Carmichael SL, Graham.JM, Lammer EJ, Shaw GM, Ma C, Rasmussen SA and the National Birth Defects Prevention Study. Fetal constraint as a potential risk factor for craniosynostosis. Am J Med Genet 2010; 152A(2):394-400.
Thursday, September 1, 2016 4:09 PM