KILLILEA

DAVID KILLILEA, PhD

An Overview

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Phone: 510-428-3885 x2376

 

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PUBLICATIONS

Zee T, Bose N, Zee J, Beck JN, Yang S, Parihar J, Yang M, Damodar S, Hall D,
O'Leary MN, Ramanathan A, Gerona RR, Killilea DW, Chi T, Tischfield J, Sahota A,
Kahn A, Stoller ML, and Kapahi P. α-Lipoic acid treatment prevents cystine
urolithiasis in a mouse model of cystinuria. Nat Med 23(3):288-290, 2017.
(PMID: 28165480)

Zyba SJ, Shenvi SV, Killilea DW, Holland TC, Kim E, Moy A, Sutherland B,
Gildengorin V, Shigenaga MK, and King JC. A moderate increase in dietary zinc reduces DNA strand breaks in leukocytes and alters plasma proteins without changing
plasma zinc concentrations. Am J Clin Nutr 105(2):343-351, 2017. (PMID: 28003206)

Khanna A, Kumar J, Vargas MA, Barrett L, Katewa S, Li P, McCloskey T, Sharma
A, Naudé N, Nelson C, Brem R, Killilea DW, Mooney SD, Gill M, and Kapahi P. A
genome-wide screen of bacterial mutants that enhance dauer formation in C.
elegans. Sci Rep 6:38764, 2016. (PMID: 27958277)

Tasian GE, Ross ME, Song L, Grundmeier RW, Massey J, Denburg MR, Copelovitch
L, Warner S, Chi T, Killilea DW, Stoller ML, and Furth SL. Dietary Zinc and Incident
Calcium Kidney Stones in Adolescence. J Urol pii: S0022-5347(16)31858-4, 2016. (PMID: 27889417)

Kumar J, Barhydt T, Awasthi A, Lithgow GJ, Killilea DW, and Kapahi P. Zinc Levels
Modulate Lifespan through Multiple Longevity Pathways in Caenorhabditis elegans.
PLoS One 11(4):e0153513, 2016. (PMID: 27078872)

Karuppagounder SS, Alim I, Khim SJ, Bourassa MW, Sleiman SF, John R, Thinnes
CC, Yeh TL, Demetriades M, Neitemeier S, Cruz D, Gazaryan I, Killilea DW,
Morgenstern L, Xi G, Keep RF, Schallert T, Tappero RV, Zhong J, Cho S, Maxfield
FR, Holman TR, Culmsee C, Fong GH, Su Y, Ming GL, Song H, Cave JW, Schofield CJ,
Colbourne F, Coppola G, and Ratan RR. Therapeutic targeting of oxygen-sensing prolyl
hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after
brain hemorrhage in several rodent models. Sci Transl Med 8(328):328ra29, 2016. (PMID: 26936506)

Holland TC, Killilea DW, Shenvi SV, and King JC. Acute changes in cellular zinc alters zinc uptake rates prior to zinc transporter gene expression in Jurkat cells. BioMetals, 28(6):987-96 2015. (PMID: 26420239)

Ramaswamy K*, Killilea DW*, Kapahi P, Kahn A, Chi T, and Stoller ML. The elementome of calcium-based urinary stones and its role in urolithiasis. Nature Rev Urol, 12(10):543-57, 2015. (*contributed equally) (PMID: 26334088)

Lee MJ, Alvarez JA, Smith EM, Killilea DW, Chmiel JF, Joseph PM, Grossmann RE, Gaggar A, Ziegler TR, and Tangpricha V. Changes in micronutrient status during and after pulmonary exacerbation in adult cystic fibrosis. Nutr Clin Pract, 2015
(PMID: 26078287)

Killilea DW
, Westropp JL, Shiraki R, Mellema M, Larsen J, Kahn AJ, Kapahi P, Chi T, and Stoller ML. Elemental Content of Calcium Oxalate Stones from a Canine Model of Urinary Stone Disease. PLOS ONE 10(6):e0128374, 2015. (PMID: 26066810)

Singer ST, Killilea DW, Suh J, Wang Z, Yuan Q, Ivani K, Evans P, Vichinsky E, Fischer R, Smith J. Fertility in transfusion-dependent thalassemia men: Effects of iron burden on the reproductive axis. American Journal of Hematology, 2015 (PMID: 26044409)

Chi T, Kim MS, Kahn A, Flechner L, Blaschko S, Lang S, Zee T, Muteliefu G, Bond N, Kolipinski M, Fakra SC, Miller J, Killilea DW, Brückner K, Kapahi P, and Stoller ML. A Drosophila Model Identifies a Critical Role for Zinc Physiology in Initiating Kidney Stone Disease. PLOS ONE 10(5), e0124150, 2015. (PMID: 25970330)

Klang IM, Schilling B, Sorensen DJ, Sahu AK, Kapahi P, Andersen JK, Swoboda P, Killilea DW, Gibson BW, and Lithgow GJ. Iron promotes protein insolubility and aging in C. elegans. Aging (Albany NY) 6(11):975-91, 2014. (PMID: 25554795)

Angeli S, Barhydt T, Jacobs R, Killilea DW, Lithgow GJ, and Andersen JK. Manganese disturbs metal and protein homeostasis in Caenorhabditis elegans. Metallomics 6(10):1816-1823, 2014. (PMID: 25057947)

Hassan F, Xu X, Nuovo G, Killilea DW, Tyrrell J, Tan CD, Tarran R, Diaz P, Jee J, Knoell, DL, Boyaka PN and Cormet-Boyaka E. Accumulation of metals in GOLD4 COPD lungs is associated with decreased CFTR levels. Respiratory Research 15(69), 2014 (PMID: 24957904)

Engle-Stone R, Ndjebayi AO, Nankap M, Killilea DW, Brown KH. Stunting Prevalence, Plasma Zinc Concentrations, and Dietary Zinc Intakes in a Nationally Representative Sample Suggest a High Risk of Zinc Deficiency Among Women and Young Children in Cameroon. J Nutr 144(3):382-91, 2014 (PMID: 24453129)

Hung YH, Faux NG, Killilea DW, Yanjanin N, Firnkes S, Volitakis I, Ganio G, Walterfang M, Hastings C, Porter FD, Ory DS, and Bush AI. Altered transition metal homeostasis in Niemann-Pick disease, Type C. Metallomics 6(3):542-53, 2014. (PMID: 24343124)

Liu MJ, Bao S, Bolin ER, Burris DL, Xu X, Sun Q, Killilea DW, Shen Q, Ziouzenkova O, Belury MA, Failla ML, and Knoell DL. Zinc deficiency augments leptin production and exacerbates macrophage infiltration into adipose tissue in mice fed a high-fat diet. J Nutr 143(7):1036-45, 2013. (PMID: 23700340)

Liu MJ, Bao S, Gálvez-Peralta M, Pyle CJ, Rudawsky AC, Pavlovicz RE, Killilea DW, Li C, Nebert DW, Wewers MD, and Knoell DL. ZIP8 regulates host defense through zinc-mediated inhibition of NF-κB. Cell Reports 3(2):386-400, 2013. (PMID: 23403290)

Page KE, White KN, McCrohan CR, Killilea DW, and Lithgow GJ. Aluminium exposure disrupts elemental homeostasis in Caenorhabditis elegans. Metallomics 4(5):512-522, 2012. (PMID: 22534883)

Killilea DW
and Maier JAM. A connection between magnesium deficiency and aging: new insights from cellular studies. Magnesium Res 21(2):77-82, 2008. (PMID: 18705534)

Killilea DW
and Ames, BN. Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts. Proc Natl Acad Sci USA 105(15):5768-5773, 2008. (PMID: 18391207)

Lal A, Atamna W, Killilea DW, Suh JH, and Ames BN. Lipoic acid and acetyl-carnitine reverses iron-induced oxidative stress in human fibroblasts. Redox Report 13(1):2-10, 2008. (PMID: 18284845)

McColl G, Killilea DW, Hubbard AE, Vantipalli MC, Melov S, and Lithgow GJ. Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans. J Biol Chem 283(1):350-357, 2008. (PMID: 17959600)

Killilea AN, Downing KH, and Killilea DW.  Zinc deficiency reduces paclitaxel efficacy in LNCaP prostate cancer cells. Cancer Lett 258(1):70-79, 2007. (PMID: 17905512)

Voloboueva LA, Killilea DW, Atamna H, and Ames BN.  N-tert-butyl hydroxylamine, a mitochondrial antioxidant, protects human retinal pigment epithelial cells from iron overload: relevance to macular degeneration. FASEB J 21(14):4077-4086, 2007. (PMID: 17656467)

Young NL, Sisto MC, Young MN, Grant PG, Killilea DW, Lamotte L, Wu KJ, and Lebrilla, CB. Steady-state asymmetric nanospray dual ion source for accurate mass determination within a chromatographic separation. Anal Chem 79(15):5711-5718, 2007. (PMID: 17614364)

De Regil LM, Casanueva E, Killilea DW, and Viteri FE.  Dialysability of minerals in corn masa gruel (atole) fortified with different iron compounds: effects of ascorbic acid, disodium-EDTA, and phytic acid. Food Nutr Bull 28(2): 198-205, 2007. (PMID: 24683679)

Walter PB, Fung EB, Killilea DW, Jiang Q, Hudes M, Madden J, Porter J, Evans P, Vichinsky E, and Harmatz P. Oxidative stress and inflammation in iron-overloaded patients with beta-thalassemia or sickle cell disease. Br J Haematol 135(2):254-263, 2006. (PMID: 17010049)

Ames BN, Atamna H, and Killilea DW. Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging. Mol Aspects Med 26(4-5):363-378, 2005. (PMID: 16102804)

Killilea DW
, Wong SL, Cahaya HS, Atamna H, and Ames BN.  Iron accumulation during cellular senescence. Ann New York Acad Sci, 1019:365-367, 2004.(PMID: 15247045)

Killilea DW
, Atamna H, Liao C, and Ames BN.  Iron accumulation during cellular senescence in human fibroblasts in vitro. Antioxid Redox Signal 5(5):507-516, 2003. (PMID: 14580305)

Atamna H, Killilea DW, Killilea AN, and Ames BN.  Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging. Proc Natl Acad Sci USA 99(23):14807-14812, 2002. (PMID: 12417755)

Liu J, Killilea DW, and Ames BN.  Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-a-lipoic acid. Proc Natl Acad Sci USA 99(4):1876-1881, 2002. (PMID: 11854488)

Grishko V, Solomon M, Breit JF, Killilea DW, LeDoux SP, Wilson GL, and Gillespie MN.  Hypoxia promotes oxidative base modifications in the pulmonary artery endothelial cell VEGF gene. FASEB J. 15(7):1267-1269, 2001. (PMID: 11344109)

Killilea DW
, Hester R, Balczon R, Babal P, and Gillespie MN.  Free radical production in hypoxic pulmonary artery smooth muscle cells. Am J Physiol 279(2):L408-L412, 2000. (PMID: 10926565)

Haynes J, Killilea DW, and Thompson WJ. Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) inhibits cGMP-stimulated phospho-diesterase (PDE2) to reverse hypoxic pulmonary vasoconstriction in the perfused rat lung. J Pharmacol Exp Ther, 276(2):752-757, 1996. (PMID: 8632346)

Updated List in MyBibliography



Revised: July 29, 2008 3:40PM

 

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