beate Illek, phd
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McGarry ME, Ly N, Illek B, Zlock, L, Olshansky S, Moreno C, Finkbeiner WE, Fischer H, Nielson D (in press) Ivacaftor in Cystic Fibrosis Patients with Clinical Signs of Residual CFTR Function: N-Of-1 Pilot Study. Pediatric Pulmonology.

Suzuki S,  Sargent RG, Illek B, Fischer H, Esmaeili-Shandiz A, Yezzi MJ, Lee A, Yang Y, Kim S, Renz P, Qi Z, Yu J, Muench MO, Beyer AI, Guimarães AO, Ye L, Chang J, Fine EJ, Cradick TJ, Bao G, Rahdar M, Porteus MH, Shuto T, Kai H, Kan YW, Gruenert DC (2016) TALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs.  Molecular Therapy–Nucleic Acid, 5, e273. PMC5012545

Schwagerus E, Sladek S, Buckley ST, Alvarez de la Rosa D, Harvey BJ, Fischer H, Illek B,  Huwer H, Daum N, Lehr C-M, Ehrhardt C (2015) Expression and function of the epithelial sodium channel δ-subunit in human respiratory epithelial cells in vitro. Eur. J. Physiol. - Pflügers Arch, 1-17. PMID: 25677639

Cho DY, Le W, Bravo DT, Hwang PH, Illek B, Fischer H, Nayak JV. (2014) Air pollutants cause release of hydrogen peroxide and interleukin-8 in a human primary nasal tissue culture model. Int. Forum. Allergy Rhinol. 2014 Dec; 4(12): 966-71. PMID: 25400124

Schwarzer C, Ravishankar B, Patanwala M, Shuai S, Fu Z, Illek B,  Fischer H,  Machen TE (2014)Thapsigargin blocks Pseudomonas aeruginosa homoserine lactone-induced apoptosis in airway epithelia. Am. J. Physiol. Cell Physiol.306: C844 - C855. PMC4010806

Cho DY, Nayak JV, Bravo DT, Le W, Nguyen A, Edward JA, Hwang PH, Illek B, Fischer H (2013) Expression of dual oxidases and secreted cytokines in chronic rhinosinusitis. Int Forum Allergy Rhinol. Vol. 3, Issue 5, 376–383. PMC4028033

de Semir D,  Maurisse R,  Du F,  Xu J,   Yang X ,  Illek B,  Gruenert DC (2012) Generation of SV40-transformed rabbit tracheal-epithelial-cell-derived blastocyst by somatic cell nuclear transfer. Cell Tissue Res. 347(2): 357-67. PMID:22234514

Schwarzer C, Fu Z, Patanwala M, Hum L, Lopez-Guzman M, Illek B, Kong W, Lynch SV, Machen TE (2012)  Pseudomonas aeruginosa biofilm-associated homoserine lactone C12 rapidly activates apoptosis in airway epithelia. Cell Microbiol. 285: 34850 – 34863. PMC4112999

Wang Y, Moreland M, Wagner JG, Ames BN, Illek B, Peden DB, Jiang Q (2012) Vitamin E forms inhibit IL-13/STAT6-induced eotaxin-3 secretion by up-regulation of PAR4, and endogenous inhibitor of atypical PKC in human lung epithelial cells. J. Nutritional Biochemistry. 23(6): 602-8. PMC3201713

Cho DY, Hwang PH, Illek B, Fischer H. (2011) Acid and Base Secretion in Freshly Excised Nasal Tissue From Cystic Fibrosis Patients with ΔF508 Mutation. Int. Forum Allergy Rhinol. Mar; 1(2):123-127. PMC3199580

Iovannisci D, Illek B, Fischer H. (2010) Function of the HVCN1 proton channel in airway epithelia and a naturally occurring mutation, M91T. J. Gen. Physiol., 136, 35-46. PMC2894549

Ballard PL, Lee JW, Fang X, Chapin CJ, Allen L, Segal MR, Fischer H, Illek B, Gonzales LW, Kolla V, Matthay MA (2010) Regulated gene expression in cultured type II cells of adult human lung. Am. J. Physiol. Lung Cell Mol. Physiol.  299: L36-L50.  PMC2904098

Cho D-Y, Hwang PH, Illek B. (2010) Characteristics of Chloride Transport in Nasal Mucosa from Patients with Primary Ciliary Dyskinesia. Laryngoscope, 120: 1460-1464. PMC3196355

Fischer H, Illek B, Sachs LA, Finkbeiner WE, Widdicombe JH (2010) CFTR and Ca-activated Cl channels in primary cultures of human airway gland cells of serous or mucous phenotype.  Am J Physiol. Lung Cell Mol. Physiol., 299: L585 - L594. PMC2957417

Burgess BL; Cavigiolio G, Fanucchi, MV, Illek B, Forte TM, Oda, MN (2010) A phospholipid-apolipoprotein-AI nano-particle containing Amphotericin B as a drug delivery platform with cell membrane protective properties. International Journal of Pharmaceutics 399 (1-2): 148-55.  PMC2946961

Schwarzer C, Wong S, Shi J, Matthes E, Illek B, Ianowski JP, Arant RJ, Isacoff EY, Vais H,  Foskett JK, Maiellaro I, Hofer AM, Machen TE (2010) Pseudomonas aeruginosa homoserine lactone activates store-operated cAMP and CFTR-dependent Cl secretion by human airway epithelia. J. Biol. Chem., 285: 34850 - 34863. PMC2966100

Illek B, Dachuan L, Fischer H, Gruenert DC (2010) Sensitivity of chloride efflux vs. transepithelial measurements in mixed CF and normal airway epithelial cell populations. J. Cellular Physiol. Biochem.26:983-990. PMC3221260

Wagner JG, Harkema JR, Jiang Q, Illek B, Ames BN, Peden DB (2009) g-Tocopherol attenuates ozone-induced exacerbations of allergic rhinosinusitis in rats. Toxicologic. Pathol. 37, 481-491. PMID: PMC4465783

Cho D-Y, Hwang PH, Illek B. (2009) Effect of L-Ascorbate on Chloride Transport in Freshly Excised Sinonasal Epithelia. Am. J. Rhinology.23: 294-299. PMC3196350

Cho D-Y, Hajighasemi M,  Hwang PH, Illek B, Fischer H (2009) Proton Secretion  in Freshly Excised Sinonasal Mucosa from Asthma and Sinusitis Patients. Am. J. Rhinology, 23(6):10-3. PMC2888960

Wagner JG, Jiang Q, Harkema JR, Ames BN, Illek B, Roubey RA, Peden DB (2008) g-Tocopherol prevents airway eosinophilia and mucous cell hyperplasia in experimentally induced allergic rhinitis and asthma. Clinical Exp. Allerg. 38(3): 501-511. PMID:17970781

Illek B, Maurisse R, Wahler L,  Kunzelmann K,  Fischer H, Gruenert DC (2008) Cl- Transport in Complemented CF Bronchial Epithelial Cells Correlates with CFTR mRNA Expression Levels. J. Cellular Physiol. Biochem. 22:57-68. PMC2927120

Illek B, Fu Z., Schwarzer C, Banzon T, Miller SS, Machen TE (2008)  Flagellin-stimulated Cl- Secretion and innate immune responses in airway epithelia: Role for p38. Am. J. Physiol. Lung Cell Mol. Physiol., 283: 27144-27153. PMC2575945

Schwarzer C , Fischer H, Kim EJ, Barber KJ,  Mills AD,  Kurth MJ, Gruenert DC,  Suh JH,  Machen TE, Illek B (2008) Oxidative Stress caused by pyocyanin impairs CFTR Cl- Transport In Human Bronchial Epithelial Cells. Free Radic. Biol. Med. 45(12): 1653-62. PMC2628806

Fischer H, Illek B (2008) Activation of the CFTR Cl- channel by trimethoxyflavone in vitro and in vivo. J. Cellular Physiol. Biochem.22: 695-702. PMC2820299

Fischer H, Illek B, Finkbeiner WE, Widdicombe JH (2007) Basolateral Cl channels in primary airway epithelial cultures. Am. J. Physiol. Lung Cell Mol. Physiol. 292, L1432-L1443. PMID:17322286

Fischer H, Gonzales LK, Kolla V, Schwarzer C, Miot F, Illek B, Ballard PL (2007) Developmental regulation and function of Duox1 in fetal lung epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol.  292, L1506-L1514. PMID:

Schwarzer C, Illek B, Suh JH, Remington SJ, Fischer H, Machen TE (2007) Organelle redox of CF and CFTR-corrected airway epithelia. Free Radic. Biol. Med. 43, 300-316. PMC4085155

Wagner JG, Jiang Q, Harkema JR, Illek B, Patel DD, Ames BN, Peden DB (2007) Ozone enhancement of lower airway allergic inflammation is prevented by g-tocopherol. Free Radic. Biol. Med. 15; 43(8):1176-88. PMC4465777

Schuier M, Sies H, Illek B, Fischer H (2005) Cocoa-related flavonoids inhibit CFTR-mediated chloride transport in T84 human colon epithelia. J. Nutr. 135, 2320-2325. PMID: 16177189

Fischer H, Illek B (2005) Vitamin C and flavonoids potentiate Cl secretion across airway epithelia. Advances in Exp. Medicine and Biology, 558, 129-143.

Fischer H, Schwarzer C, Illek B (2004) Vitamin C controls the cystic fibrosis transmembrane conductance regulator chloride channel. Proc. Natl. Acad. Sci. USA 101, 3691-3696. PMC373524

Fischer H, Machen TE, Widdicombe JH, Carlson TJS, King SR, Chow WS, Illek B (2004) A novel extract SB-300 from the bark latex of Croton lechleri inhibits CFTR-mediated chloride secretion in human colonic epithelial cells. J. Ethnopharmacol. 95, 351-357. PMID:15234776

Schwarzer C, Illek B, Machen TE, Fischer H. NADPH oxidase-dependent acid production and secretion in airway epithelial cells. (2004) J. Biol. Chem. 279: 36454-36461. PMID:15210697

Tong Z, Illek B, Bhaghwandin VJ,  Verghese GM, Caughey GH (2004) Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in cystic fibrosis airway epithelia. Am. J. Physiol.,287, L928-L935. PMID:

Chung NC, Illek B, Widdicombe JH, Fischer H (2003) Measurement of nasal potential difference in asthmatics. Chest 123, 1467-1471. PMID: 12740262

Fischer H, Widdicombe JH, Illek B (2002) Acid secretion and proton conductance in human airway epithelium. Am. J. Physiol. 282, C736-C743. PMID: 11880261

Fischer H, Fukuda N, Barby P, Illek B, Sartori C, Matthay MA (2001) Partial restoration of the chloride conductance in ?F508 cystic fibrosis mice by the chemical chaperone trimethylamine oxide (TMAO). Am. J. Physiol. 281, L52-57.  PMID: 11404245

Illek B, Lizarzaburu ME, Lee V, Nantz MH, Kurth MJ, Fischer H  (2000) Structural determinants for activation and block of CFTR-mediated chloride currents by apigenin. Am. J. Physiol. 279, C1838-1846. PMID:11078699

Biesalski HK, Frank J, Beck SC, Heinrich F, Illek B, Reifen R, Gollnick H, Seeliger MW, Wissinger B, Zrenner E. (1999) Biochemical but not clinical vitamin A deficiency due to mutations in the gene for retinol-binding protein.  Am. J. Clin. Nutrition, 69, 931-936. PMID:10232633

Illek B, Tam AWK, Machen TE. (1999) Illek B, Tam AWK, Machen TE. (1999) Anion selectivity of apical membrane conductance of Calu 3 human airway epithelium. Eur. J. Physiol. - Pfluegers Arch 437, 812-822. PMID:10370058

Illek B, Zang L, Lewis NC, Moss RB, Dong JY, Fischer H  (1999) Defective function of the cystic fibrosis missense mutation G551D is recovered by genistein. Am. J. Physiol. 277, C833-839. PMID:10516113

Illek B, Fischer H (1998) Flavonoids stimulate Cl conductance of human airway epithelium in vitro and in vitro. Am. J. Physiol. 275,L902-910. PMID:9815107

Illek B, Machen TE, Widdicombe JH, Fischer H (1998) Stimulation of cystic fibrosis trans-membrane conductance regulator chloride channel (CFTR) by flavonoids. Emerging Therapeutic Targets  2: 1-4.

Fischer H, Illek B, Machen TE (1998) Regulation of CFTR by protein phosphatase 2B and protein kinase C. Eur J Physiol - Pfluegers Arch  436, 175-181. PMID:9594016

Uyekubo SN, Fischer H, Maminishkis A, Illek B, Miller SS, Widdicombe JH. (1998) cAMP-dependent absorption of chloride across airway epithelium. Am. J. Physiol.  275, L1219-1227. PMID:9843860

Illek B, Fischer H, Machen TE (1998) Genetic Disorders of membrane transport. II. Regulation of CFTR by small molecules including HCO3. Am. J. Physiol. 275 (Gastrointest. and Liver Physiol. 38): G1221-G1226. PMID:

Illek B, Yankaskas JR, Machen TE (1997) cAMP and genistein stimulate HCO3 conductance through CFTR in human airway epithelia. Am. J. Physiol. 272, L752-761. PMID:9142951

Illek B, Fischer H, Machen TE (1996) Alternate regulation of apical CFTR by genistein in epithelia. Am. J. Physiol. 270, C265-275. PMID:8772453

Fischer H, Illek B, Machen TE (1995) The actin filament disrupter  cytochalasin  D  activates the recombinant CFTR in 3T3 cells.  J. Physiol. London 489, 745-754. PMC1156844

Illek B, Fischer H, Santos GF, Widdicombe JH, Machen TE, Reenstra WW (1995) cAMP-independent activation of CFTR Cl channels by the tyrosine kinase inhibitor genistein. Am. J. Physiol. 268, C886-893. PMID:7537452

Bischof G, Illek B, Reenstra WW, Machen TE (1995). Role for tyrosine kinases in carbachol-regulated Ca entry into colonic epithelial cells. Am. J. Physiol. 268:C154-61. PMID:7840144

Poulsen JH, Fischer H, Illek B, Machen TE (1994) Bicarbonate conductance and a pH regulatory capability of CFTR. Proc. Natl. Acad. Sci. USA 91, 5360-5344. PMC43990

Illek B, Fischer H, Clauss W (1993) Quinidine-sensitive K+ channels in the basolateral membrane of embryonic coprodeum epithelium: regulation by aldosterone and thyroxine. J. Comp. Physiol. B 163, 556-562. PMID: 8151014

Fischer H, Illek B, Negulescu PA, Clauss W, Machen TE (1992) Carbachol-activated calcium entry into HT-29 cells is regulated by both membrane potential and cell volume. Proc. Natl. Acad. Sci. USA 89, 1438-1442. PMC48466

Illek B, Fischer H, Kreusel KM, Hegel U, Clauss W (1992) Volume-sensitive basolateral K+ channels in HT-29/B6 cells: block by lidocaine, quinidine, NPPB, and Ba2+. Am. J. Physiol. 263, C674-683. PMID:1415516

Illek B, Fischer H, Machen TE (1992) Intracellular Ca2+ signaling modulated by K+ channel blockers in colonic epithelial cells (HT-29/B6). Eur. J. Physiol. - Pflügers Arch 422, 48-54. PMID:1437524

Fischer H, Kreusel KM, Illek B, Machen TE, Hegel U, Clauss W (1992)  The outwardly rectifying Cl channel is not involved in cAMP mediated  Cl secretion in HT-29 cells: evidence for a very low conductance channel. Eur. J. Physiol. - Pflügers Arch 422, 159-167. PMID:1283217

Illek B, Fischer H, Clauss W (1990) Aldosterone regulates basolateral potassium channels in the alveolar epithelium of the frog Xenopus laevis. Am. J. Physiol. 259, L230-L237. PMID:2221084

Revised: Tuesday, June 13, 2017 8:50 AM


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