Email: Laura Hertel, PhD
Phone: 510-450-7989

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Overview

Human cytomegalovirus (CMV) infections are a serious source of morbidity and mortality for immunocompromised individuals such as AIDS patients, transplant recipients, and newborns. Because of this, the development of novel strategies to block viral dissemination to new organs within infected individuals, to interfere with the lifelong maintenance of viral genomes during latency, and to generate effective immune responses following vaccination is a priority.

Dr. Laura Hertel’s research focuses on the interactions between human CMV and the hematopoietic cell system, including the CD34+ progenitor cells, the main site of viral latency, and dendritic cells, the essential initiators of immune responses against this virus.
The immediate goals of Dr. Hertel’s research are to: 1) determine the mechanisms supporting long-term maintenance of latent viral genomes in CD34+ progenitor cells; 2) identify the viral and cellular factors contributing to viral tropism for dendritic cells and 3) characterize the responses of DC and their progenitors to CMV infection, with the ultimate purpose of providing new targets for the design of improved anti-viral therapies and of an effective anti-CMV vaccine.

 

Revised: Wednesday, December 17, 2014 3:48 PM

 


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