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“The goal of our research is to explore a variety of current problems in our field via national and international collaborative studies on cystic fibrosis and asthma; state studies specifically on our infants screened and positive for cystic fibrosis; and individual studies devised for individual patients by our fellows training in pediatric pulmonology.”

Dr. Hardy and her team of pediatric pulmonologists work together to undertake clinical trials in addition to daily clinical practice that span state, national and international boundaries. Current studies include participation in an international project to evaluate the safety and efficacy of long acting beta agonists (LABA) in combination with inhaled steroids for young children with asthma, and nearly half a dozen national studies that explore a variety of different issues from the genotypic and phenotypic differences or similarities of cystic fibrosis (CF) disease progression between twins and siblings, to pulmonary changes in patients receiving bone marrow transplant for sickle cell disease or therapeutic enzyme replacement for a condition called mucopolysaccardosis. In addition, Dr. Hardy and her colleagues are participating in California state studies that investigate the benefit of using sweat studies for CF diagnosis in newborns through two years of age, and the proficiency of genetic CF testing that will help serve as a pilot program for the Center for Disease Control to develop a national proficiency testing protocol.

In addition, a variety of fellows have been undertaking individual research projects as part of their successful graduation from the pediatric pulmonary fellowship. Dr. Villa is evaluating the effect of surgery to remove tonsils and adenoids on children with obstructive sleep apnea and asthma, while Dr. Bseikri is working with Senior Scientist Bruce Ames, PhD, to develop a translational project focusing on the effect of repleting micronutrient deficiencies in urban obese asthmatic teens in the Bay Area. This will be achieved by administering a specially developed nutrient bar twice daily along with exercise, nutritional and lifestyle education. While the research undertaken by Dr. Hardy and her colleagues can be as varied as the patients they see in the pediatric intensive care unit, the common theme among all the research is to improve the pulmonary health and wellbeing of children, both those they see in daily practice and those they will never meet.

Revised: Friday, August 3, 2012 4:10 PM


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