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: Dan Granoff
Phone: 510-450-7640

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PEER REVIEWED RESEARCH ARTICLES, 2012-2014

2014
Lewis LA, Vu DM, Granoff DM and Ram, S. Inhibition of the alternative pathway of nonhuman infant complement by porin B2 contributes to virulence of Neisseria meningitidis in the infant rat model. Infection and Immunity 2014;82:2574-2584. PubMed ID: 24686052.
Abstract

Costa I, Pajon R and Granoff DM. Human factor H (FH) impairs protective meningococcal anti-FHbp antibody responses and the antibodies enhance FH binding. mBio 2014;5:e01625-14.
PDF

Granoff DM. Improving safety and efficacy of meningococcal vaccines. Microbe 2014;9:321-327.
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Shaughnessy J, Vu DM, Punjabi R, Serra-Pladevall J, DeOliveira RB, Granoff DM, and Ram S. Fusion protein comprising factor H domains 6 and 7 and human IgG1 Fc as an antibacterial immunotherapeutic. Clinical Vaccine and Immunology 2014;21:1452-1459. PubMed ID: 25143339.
Abstract

Beernink PT, Shaughnessy J, Stefek H, Ram S and Granoff DM. Heterogeneity in rhesus macaque complement factor H binding to meningococcal factor H binding protein (FHbp) informs selection of primates to assess immunogenicity of FHbp-based vaccines. Clinical Vaccine and Immunology 2014;21:1505-1511. PubMed ID: 25185576.
Abstract

2013
Lewis LA, Vu DM, Vasudhev S, Shaughnessy J, Granoff DM, and Ram S. Factor H-dependent alternative pathway inhibition mediated by porin B contributes to virulence of Neisseria meningitidis. mBio, 2013; 4:e00339-e00413. PubMed ID: 24129254.
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Rossi R, Granoff DM, and Beernink PT. Meningococcal factor H-binding protein vaccines with decreased binding to human complement factor H have enhanced immunogenicity in human factor H transgenic mice. Vaccine, 2013; 31:5451-7. PubMed ID: 24035433.
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Konar M, Granoff DM, Beernink PT. Importance of inhibition of binding of complement factor H for serum bactericidal antibody responses to meningococcal factor H-binding protein vaccines. Journal of Infectious Diseases, 2013; June 26, Epub. PubMed ID: 23715659.
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Pajon R, Fergus AM, and Granoff DM. Mutant native outer membrane vesicles combined with a serogroup A polysaccharide conjugate vaccine for prevention of meningococcal epidemics in Africa. PLoS One, 2013; 8:e66536. PubMed ID: 23805230.
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Giuntini S, Vu DM, and Granoff DM. fH-dependent complement evasion by disease-causing meningococcal strains with absent fHbp genes or frameshift mutations. Vaccine, 2013; June 17, Epub. PubMed ID: 23791680.
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Granoff DM, Ram S, and Beernink PT. Does binding of complement factor H to the meningococcal vaccine antigen, factor H-binding protein, decrease protective serum antibody responses? Clinical and Vaccine Immunology, 2013; June 5, Epub. PubMed ID: 23740919.
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Granoff DM. Portrait: Coincidences, convergences and opportunities. Human Vaccines and Immunotherapeutics, 2013; 9:945-49. PubMed ID: 23807081.
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Granoff DM. Commentary: European Medicines Agency recommends approval of a broadly protective vaccine against serogroup B meningococcal disease. Pediatric Infectious Disease Journal, 2013; 32:372-73. PubMed ID: 23263177.
Citation

2012
Pajon R, Beernink PT, and Granoff DM. Design of meningococcal factor H binding protein mutant vaccines that do not bind human complement factor H. Infection and Immunity, 2012; 80:2667-677. PubMed ID: 22615247.
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Beernink PT, Shaughnessy J, Pajon R, Braga EM, Ram S, and Granoff DM. The effect of human factor H on immunogenicity of meningococcal native outer membrane vesicle vaccines with over-expressed factor H binding protein. PLoS Pathogens, 2012; 8:e1002688. PubMed ID: 22589720.
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Vu DM, Pajon R, Reason DC, and Granoff DM. A broadly cross-reactive monoclonal antibody against an epitope on the N-terminus of meningococcal fHbp. Scientific Reports, 2012; 2:341. PubMed ID: 22461972.
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Giuntini S, Beernink PT, Reason DC, and Granoff DM. Monoclonal antibodies to meningococcal factor H binding protein with overlapping epitopes and discordant functional activity.  PLoS One, 2012; 7:e34272. PubMed ID: 22461909.
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Vu DM, Shaughnessy J, Lewis LA, Ram S, Rice PA, and Granoff DM.  Enhanced bacteremia in human factor H transgenic rats infected by Neisseria meningitidis. Infection and Immunity, 2012; 80:643-50. PubMed ID: 22104107.
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Giuntini S, Reason DC, and Granoff DM. Combined roles of human IgG subclass, alternative complement pathway activation, and epitope density on bactericidal activity of antibodies to meningococcal factor H binding protein. Infection and Immunity, 2012; 80:187-94.  PubMed ID: 22064712.
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CHAPTERS
Granoff DM, Pelton S, and Harrison LH. Meningococcal vaccines. In: Plotkin SA, Orenstein WA, and Offit PA, editors. Vaccines. 6th ed. Philadelphia: Saunders Elsevier; 2013. p 388-418.

Granoff DM and Gilsdorf JR. Neisseria meningitidis (Meningococcus). In:  Kliegman RM, Stanton B, St. Geme J, Schor N, and Behrman RE, editors. Nelson Textbook of Pediatrics. 19th ed. Philadelphia: Saunders Elsevier; 2012. p 929-935.

Revised: Tuesday, November 25, 2014 3:40 PM

 


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