PEER REVIEWED RESEARCH ARTICLES, 2010-2013

2013
Granoff DM. Coincidences, convergences and opportunities. Human Vaccines and Therapeutics, 2013; in press.

Konar M, Granoff DM, Beernink PT. Importance of inhibition of binding of complement factor H for serum bactericidal antibody responses to meningococcal factor H-binding protein vaccines. Journal of Infectious Diseases, 2013; in press.

Granoff DM. Commentary: European Medicines Agency recommends approval of a broadly protective vaccine against serogroup B meningococcal disease. Pediatric Infectious Disease Journal, 2013; 32:372-73. PubMed ID: 23263177.
Abstract

2012
Pajon R, Beernink PT, and Granoff DM. Design of meningococcal factor H binding protein mutant vaccines that do not bind human complement factor H. Infection and Immunity, 2012; Epub, 2012 May 21. PubMed ID: 22615247.
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Beernink PT, Shaughnessy J, Pajon R, Braga EM, Ram S, and Granoff DM. The effect of human factor H on immunogenicity of meningococcal native outer membrane vesicle vaccines with over-expressed factor H binding protein. PLoS Pathogens, 2012; 8:e1002688. PubMed ID: 22589720.
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Vu DM, Pajon R, Reason DC, and Granoff DM. A broadly cross-reactive monoclonal antibody against an epitope on the N-terminus of meningococcal fHbp. Scientific Reports, 2012; 2:341. PubMed ID: 22461972.
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Giuntini S, Beernink PT, Reason DC, and Granoff DM. Monoclonal antibodies to meningococcal factor H binding protein with overlapping epitopes and discordant functional activity.  PLoS One, 2012; 7:e34272. PubMed ID: 22461909.
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Vu DM, Shaughnessy J, Lewis LA, Ram S, Rice PA, and Granoff DM.  Enhanced bacteremia in human factor H transgenic rats infected by Neisseria meningitidis. Infection and Immunity, 2012; 80:643-50. PubMed ID: 22104107.
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Giuntini S, Reason DC, and Granoff DM. Combined roles of human IgG subclass, alternative complement pathway activation, and epitope density on bactericidal activity of antibodies to meningococcal factor H binding protein. Infection and Immunity, 2012; 80:187-94.  PubMed ID: 22064712.
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2011
Pajon R, Fergus AM, Koeberling O, Caugant DA, and Granoff DM. Meningococcal factor H binding proteins in epidemic strains from Africa: implications for vaccine development. PLoS Neglected Tropical Diseases, 2011; 5:e1302. PubMed ID: 21909444.
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Giuntini S, Reason DC, and Granoff DM. Complement-mediated bactericidal activity of anti-factor H binding protein monoclonal antibodies against the meningococcus relies upon blocking factor H binding. Infection and Immunity, 2011; 79:3751-59. PubMed ID: 21708990
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Koeberling O, Seubert A, Santos G, Colaprico A, Ugozzoli M, Donnelly D, and Granoff DM. Immunogenicity of a meningococcal native outer membrane vesicle vaccine with attenuated endotoxin and over-expressed factor H binding protein in infant rhesus monkeys. Vaccine, 2011; 29:4728-34.  PubMed ID: 21571025
Abstract

Koeberling O, Delaney I, and Granoff DM.  A critical threshold of meningococcal factor H binding protein is required for increased breadth of protective antibodies elicited by native outer membrane vesicle vaccines. Clinical and Vaccine Immunology, 2011; 18:736-42. PubMed ID: 21367981
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Beernink PT, Shaughnessy J, Braga EM, Liu Q, Rice PR, Ram S, and Granoff DM. A meningococcal factor H binding protein mutant that eliminates factor H binding enhances protective antibody responses to vaccination. Journal of Immunology, 2011; 186:3606-14. PubMed ID: 21325619
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Vu DM, Wong TT, and Granoff DM. Cooperative serum bactericidal activity between human antibodies to meningococcal factor H binding protein and Neisserial heparin binding antigen. Vaccine, 2011; 29:1968-1973. PubMed ID: 21241734
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Dunphy KY, Beernink PT, Brogioni B, and Granoff DM. Effect of factor H-binding protein sequence variation on factor H binding and survival of Neisseria meningitidis in human blood. Infection and Immunity, 2011; 79:353-359. PubMed ID: 21041484
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2010
Beernink PT, Shaughnessy J, Ram S, and Granoff DM. Impaired immunogenicity of a meningococcal factor H-binding protein vaccine engineered to eliminate factor H binding. Clinical and Vaccine Immunology, 2010; 17:1074-1078. PubMed ID: 20519444.
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Granoff DM. Review of meningococcal group B vaccines. Clinical Infectious Diseases, 2010; 50(suppl 2):54-65 PubMed ID 20144017.
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Pajon R, Beernink PT, Harrison LH, and Granoff DM. Frequency of factor H-binding protein modular groups and susceptibility to cross-reactive bactericidal activity in invasive meningococcal isolates. Vaccine, 2010; 28:2122-2129. PubMed ID: 20044056.
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CHAPTERS
Granoff DM, Pelton S, and Harrison LH. Meningococcal vaccines. In: Plotkin SA, Orenstein WA, and Offit PA, editors. Vaccines. 6th ed. Philadelphia: Saunders Elsevier; 2013. p 388-418.

Granoff DM and Gilsdorf JR. Neisseria meningitidis (Meningococcus). In:  Kliegman RM, Stanton B, St. Geme J, Schor N, and Behrman RE, editors. Nelson Textbook of Pediatrics. 19th ed. Philadelphia: Saunders Elsevier; 2011. p 929-935.

Revised: Monday, May 20, 2013 4:54 PM