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: Dan Granoff
Phone: 510-450-7640

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Granoff DM, Giuntini S, Gowans FA, Lujan E, Sharkey K, Beernink PT. Enhanced protective antibody to a mutant meningococcal factor H-binding protein with low-factor H binding. Journal of Clinical Investigation Insight 2016;1: e88907.
PubMed ID: 27668287.

Giuntini S, Granoff DM, Beernink PT, Ihle O, Bratlie D, Michaelsen TE. Human IgG1, IgG3, and IgG3 hinge-truncated mutants show different protection capabilities against meningococci depending on the target antigen and epitope specificity. Clinical Vaccine and Immunology 2016;23:698-706. PubMed ID: 27307451.

Pajon R, Lujan E, and Granoff DM. A meningococcal NOMV-FHbp vaccine for Africa elicits broader serum bactericidal antibody responses against serogroup B and non-B strains than a licensed serogroup B vaccine. Vaccine 2016;34:643-649.
PubMed ID: 26709637.

Rossi R, Beernink PT, Giuntini S, and Granoff DM. Susceptibility of meningococcal strains responsible for two serogroup B outbreaks on U.S. university campuses to serum bactericidal activity elicited by the MenB-4C vaccine. Clinical Vaccine and Immunology 2015;22:1227-1234. PubMed ID: 26424832.

Giuntini S, Beernink PT, and Granoff DM. Effect of complement Factor H on anti-FHbp serum bactericidal antibody responses of infant rhesus macaques boosted with a licensed meningococcal serogroup B vaccine. Vaccine 2015;33:7168-7175. PubMed ID: 26562320.

Lujan E, Pajon R, and Granoff DM. Impaired immunogenicity of meningococcal neisserial surface protein A in human complement factor H transgenic mice. Infection and Immunity 2015;84:452-458. PubMed ID: 26597984.

Granoff DM, Costa I, Konar M, Giuntini S, Van Rompay KK and Beernink PT. Binding of complement factor H (FH) decreases protective anti-FH binding protein antibody responses of infant rhesus macaques immunized with a meningococcal serogroup B vaccine. Journal of Infectious Diseases 2015;212:784-792. PubMed ID: 25676468.

Konar M, Beernink PT, and Granoff DM. A newly-identified polymorphism in rhesus macaque complement factor H modulates binding affinity for meningococcal FHbp. PLoS One 2015;10:e0135996. PubMed ID: 26285122.

Beernink PT, Giuntini S, Costa I, Lucas AH and Granoff DM. Functional analysis of the human antibody response to meningococcal factor H binding protein. mBio 2015;6:e00842. PubMed ID: 26106082.

Giuntini S, Pajon R, Ram S and Granoff DM. Binding of complement factor H to PorB3 and NspA enhances resistance of Neisseria meningitidis to anti-factor H binding protein bactericidal activity. Infection and Immunity 2015;83:1536-1545. PubMed ID: 25644002.

Pajon R, Buckwalter CM, Johswich KO, Gray-Owen SD and Granoff DM. A native outer membrane vesicle vaccine confers protection against meningococcal colonization in human CEACAM1 transgenic mice. Vaccine 2015;33:1317-1323. PubMed ID: 25662856.

Lewis LA, Vu DM, Granoff DM and Ram, S. Inhibition of the alternative pathway of nonhuman infant complement by porin B2 contributes to virulence of Neisseria meningitidis in the infant rat model. Infection and Immunity 2014;82:2574-2584. PubMed ID: 24686052.

Costa I, Pajon R and Granoff DM. Human factor H (FH) impairs protective meningococcal anti-FHbp antibody responses and the antibodies enhance FH binding. mBio 2014;5:e01625-14. PubMed ID: 25161192.

Granoff DM. Improving safety and efficacy of meningococcal vaccines. Microbe 2014;9:321-327.

Shaughnessy J, Vu DM, Punjabi R, Serra-Pladevall J, DeOliveira RB, Granoff DM, and Ram S. Fusion protein comprising factor H domains 6 and 7 and human IgG1 Fc as an antibacterial immunotherapeutic. Clinical Vaccine and Immunology 2014;21:1452-1459. PubMed ID: 25143339.

Beernink PT, Shaughnessy J, Stefek H, Ram S and Granoff DM. Heterogeneity in rhesus macaque complement factor H binding to meningococcal factor H binding protein (FHbp) informs selection of primates to assess immunogenicity of FHbp-based vaccines. Clinical Vaccine and Immunology 2014;21:1505-1511. PubMed ID: 25185576.

Lewis LA, Vu DM, Vasudhev S, Shaughnessy J, Granoff DM, and Ram S. Factor H-dependent alternative pathway inhibition mediated by porin B contributes to virulence of Neisseria meningitidis. mBio 2013;4:e00339-e00413. PubMed ID: 24129254.

Rossi R, Granoff DM, and Beernink PT. Meningococcal factor H-binding protein vaccines with decreased binding to human complement factor H have enhanced immunogenicity in human factor H transgenic mice. Vaccine 2013; 31:5451-7. PubMed ID: 24035433.

Konar M, Granoff DM and Beernink PT. Importance of inhibition of binding of complement factor H for serum bactericidal antibody responses to meningococcal factor H-binding protein vaccines. Journal of Infectious Diseases 2013;208:627-636. PubMed ID: 23715659.

Pajon R, Fergus AM, and Granoff DM. Mutant native outer membrane vesicles combined with a serogroup A polysaccharide conjugate vaccine for prevention of meningococcal epidemics in Africa. PLoS One 2013; 8:e66536. PubMed ID: 23805230.

Giuntini S, Vu DM, and Granoff DM. fH-dependent complement evasion by disease-causing meningococcal strains with absent fHbp genes or frameshift mutations. Vaccine 2013;31:4192-4199. PubMed ID: 23791680.

Granoff DM, Ram S, and Beernink PT. Does binding of complement factor H to the meningococcal vaccine antigen, factor H-binding protein, decrease protective serum antibody responses? Clinical and Vaccine Immunology 2013;20:1099-1107. PubMed ID: 23740919.

Granoff DM. Portrait: Coincidences, convergences and opportunities. Human Vaccines and Immunotherapeutics 2013;9:945-49. PubMed ID: 23807081.

Granoff DM. Commentary: European Medicines Agency recommends approval of a broadly protective vaccine against serogroup B meningococcal disease. Pediatric Infectious Disease Journal 2013;32:372-73. PubMed ID: 23263177.

Granoff DM, Pelton S, and Harrison LH. Meningococcal vaccines. In: Plotkin SA, Orenstein WA, and Offit PA, editors. Vaccines. 6th ed. Philadelphia: Saunders Elsevier; 2013. p 388-418.

Granoff DM and Gilsdorf JR. Neisseria meningitidis (Meningococcus). In:  Kliegman RM, Stanton B, St. Geme J, Schor N, and Behrman RE, editors. Nelson Textbook of Pediatrics. 19th ed. Philadelphia: Saunders Elsevier; 2012. p 929-935.

Revised: Wednesday, October 5, 2016 3:06 PM


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