PEER REVIEWED RESEARCH ARTICLES, 2013-2016
Giuntini S, Granoff DM, Beernink PT, Ihle O, Bratlie D, Michaelsen TE. Human IgG1, IgG3, and IgG3 hinge-truncated mutants show different protection capabilities against meningococci depending on the target antigen and epitope specificity. Clinical Vaccine and Immunology 2016;23:698-706. PubMed ID: 27307451.
Pajon R, Lujan E, and Granoff DM. A meningococcal NOMV-FHbp vaccine for Africa elicits broader serum bactericidal antibody responses against serogroup B and non-B strains than a licensed serogroup B vaccine. Vaccine 2016;34:643-649.
Giuntini S, Beernink PT, and Granoff DM. Effect of complement Factor H on anti-FHbp serum bactericidal antibody responses of infant rhesus macaques boosted with a licensed meningococcal serogroup B vaccine. Vaccine 2015;33:7168-7175. PubMed ID: 26562320.
Lujan E, Pajon R, and Granoff DM. Impaired immunogenicity of meningococcal neisserial surface protein A in human complement factor H transgenic mice. Infection and Immunity 2015;84:452-458. PubMed ID: 26597984.
Granoff DM, Costa I, Konar M, Giuntini S, Van Rompay KK and Beernink PT. Binding of complement factor H (FH) decreases protective anti-FH binding protein antibody responses of infant rhesus macaques immunized with a meningococcal serogroup B vaccine. Journal of Infectious Diseases 2015;212:784-792. PubMed ID: 25676468.
Konar M, Beernink PT, and Granoff DM. A newly-identified polymorphism in rhesus macaque complement factor H modulates binding affinity for meningococcal FHbp. PLoS One 2015;10:e0135996. PubMed ID: 26285122.
Beernink PT, Giuntini S, Costa I, Lucas AH and Granoff DM. Functional analysis of the human antibody response to meningococcal factor H binding protein. mBio 2015;6:e00842. PubMed ID: 26106082.
Pajon R, Buckwalter CM, Johswich KO, Gray-Owen SD and Granoff DM. A native outer membrane vesicle vaccine confers protection against meningococcal colonization in human CEACAM1 transgenic mice. Vaccine 2015;33:1317-1323. PubMed ID: 25662856.
Costa I, Pajon R and Granoff DM. Human factor H (FH) impairs protective meningococcal anti-FHbp antibody responses and the antibodies enhance FH binding. mBio 2014;5:e01625-14. PubMed ID: 25161192.
Granoff DM. Improving safety and efficacy of meningococcal vaccines. Microbe 2014;9:321-327.
Shaughnessy J, Vu DM, Punjabi R, Serra-Pladevall J, DeOliveira RB, Granoff DM, and Ram S. Fusion protein comprising factor H domains 6 and 7 and human IgG1 Fc as an antibacterial immunotherapeutic. Clinical Vaccine and Immunology 2014;21:1452-1459. PubMed ID: 25143339.
Beernink PT, Shaughnessy J, Stefek H, Ram S and Granoff DM. Heterogeneity in rhesus macaque complement factor H binding to meningococcal factor H binding protein (FHbp) informs selection of primates to assess immunogenicity of FHbp-based vaccines. Clinical Vaccine and Immunology 2014;21:1505-1511. PubMed ID: 25185576.
Rossi R, Granoff DM, and Beernink PT. Meningococcal factor H-binding protein vaccines with decreased binding to human complement factor H have enhanced immunogenicity in human factor H transgenic mice. Vaccine 2013; 31:5451-7. PubMed ID: 24035433.
Konar M, Granoff DM and Beernink PT. Importance of inhibition of binding of complement factor H for serum bactericidal antibody responses to meningococcal factor H-binding protein vaccines. Journal of Infectious Diseases 2013;208:627-636. PubMed ID: 23715659.
Pajon R, Fergus AM, and Granoff DM. Mutant native outer membrane vesicles combined with a serogroup A polysaccharide conjugate vaccine for prevention of meningococcal epidemics in Africa. PLoS One 2013; 8:e66536. PubMed ID: 23805230.
Giuntini S, Vu DM, and Granoff DM. fH-dependent complement evasion by disease-causing meningococcal strains with absent fHbp genes or frameshift mutations. Vaccine 2013;31:4192-4199. PubMed ID: 23791680.
Granoff DM, Ram S, and Beernink PT. Does binding of complement factor H to the meningococcal vaccine antigen, factor H-binding protein, decrease protective serum antibody responses? Clinical and Vaccine Immunology 2013;20:1099-1107. PubMed ID: 23740919.
Granoff DM. Portrait: Coincidences, convergences and opportunities. Human Vaccines and Immunotherapeutics 2013;9:945-49. PubMed ID: 23807081.
Granoff DM. Commentary: European Medicines Agency recommends approval of a broadly protective vaccine against serogroup B meningococcal disease. Pediatric Infectious Disease Journal 2013;32:372-73. PubMed ID: 23263177.
Granoff DM and Gilsdorf JR. Neisseria meningitidis (Meningococcus). In: Kliegman RM, Stanton B, St. Geme J, Schor N, and Behrman RE, editors. Nelson Textbook of Pediatrics. 19th ed. Philadelphia: Saunders Elsevier; 2012. p 929-935.
Revised: Wednesday, October 5, 2016 3:06 PM