DAN M. GRANOFF, MD
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: Dan Granoff
Phone: 510-450-7640

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PEER REVIEWED RESEARCH ARTICLES, 2014-2017

2017
Giuntini S, Lujan E, Gibani MM, Dold C, Rollier CS, Pollard AJ and Granoff DM. Serum bactericidal antibody responses of adults immunized with the MenB-4C vaccine against genetically diverse serogroup B meningococci. Clinical Vaccine and Immunology 2017;5:e00430. PubMed ID: 27847367.
Abstract

2016
Granoff DM, Giuntini S, Gowans FA, Lujan E, Sharkey K, and Beernink PT. Enhanced protective antibody to a mutant meningococcal factor H-binding protein with low-factor H binding. Journal of Clinical Investigation Insight 2016;1:e88907.
PubMed ID: 27668287.
PDF

Giuntini S, Granoff DM, Beernink PT, Ihle O, Bratlie D, and Michaelsen TE. Human IgG1, IgG3, and IgG3 hinge-truncated mutants show different protection capabilities against meningococci depending on the target antigen and epitope specificity. Clinical Vaccine and Immunology 2016;23:698-706. PubMed ID: 27307451.
PDF

Pajon R, Lujan E, and Granoff DM. A meningococcal NOMV-FHbp vaccine for Africa elicits broader serum bactericidal antibody responses against serogroup B and non-B strains than a licensed serogroup B vaccine. Vaccine 2016;34:643-649.
PubMed ID: 26709637.
PDF

2015
Rossi R, Beernink PT, Giuntini S, and Granoff DM. Susceptibility of meningococcal strains responsible for two serogroup B outbreaks on U.S. university campuses to serum bactericidal activity elicited by the MenB-4C vaccine. Clinical Vaccine and Immunology 2015;22:1227-1234. PubMed ID: 26424832.
PDF

Giuntini S, Beernink PT, and Granoff DM. Effect of complement Factor H on anti-FHbp serum bactericidal antibody responses of infant rhesus macaques boosted with a licensed meningococcal serogroup B vaccine. Vaccine 2015;33:7168-7175. PubMed ID: 26562320.
Abstract

Lujan E, Pajon R, and Granoff DM. Impaired immunogenicity of meningococcal neisserial surface protein A in human complement factor H transgenic mice. Infection and Immunity 2015;84:452-458. PubMed ID: 26597984.
PDF

Granoff DM, Costa I, Konar M, Giuntini S, Van Rompay KK and Beernink PT. Binding of complement factor H (FH) decreases protective anti-FH binding protein antibody responses of infant rhesus macaques immunized with a meningococcal serogroup B vaccine. Journal of Infectious Diseases 2015;212:784-792. PubMed ID: 25676468.
PDF

Konar M, Beernink PT, and Granoff DM. A newly-identified polymorphism in rhesus macaque complement factor H modulates binding affinity for meningococcal FHbp. PLoS One 2015;10:e0135996. PubMed ID: 26285122.
PDF

Beernink PT, Giuntini S, Costa I, Lucas AH and Granoff DM. Functional analysis of the human antibody response to meningococcal factor H binding protein. mBio 2015;6:e00842. PubMed ID: 26106082.
PDF

Giuntini S, Pajon R, Ram S and Granoff DM. Binding of complement factor H to PorB3 and NspA enhances resistance of Neisseria meningitidis to anti-factor H binding protein bactericidal activity. Infection and Immunity 2015;83:1536-1545. PubMed ID: 25644002.
PDF

Pajon R, Buckwalter CM, Johswich KO, Gray-Owen SD and Granoff DM. A native outer membrane vesicle vaccine confers protection against meningococcal colonization in human CEACAM1 transgenic mice. Vaccine 2015;33:1317-1323. PubMed ID: 25662856.
PDF

2014
Lewis LA, Vu DM, Granoff DM and Ram, S. Inhibition of the alternative pathway of nonhuman infant complement by porin B2 contributes to virulence of Neisseria meningitidis in the infant rat model. Infection and Immunity 2014;82:2574-2584. PubMed ID: 24686052.
PDF

Costa I, Pajon R and Granoff DM. Human factor H (FH) impairs protective meningococcal anti-FHbp antibody responses and the antibodies enhance FH binding. mBio 2014;5:e01625-14. PubMed ID: 25161192.
PDF

Granoff DM. Improving safety and efficacy of meningococcal vaccines. Microbe 2014;9:321-327.
PDF

Shaughnessy J, Vu DM, Punjabi R, Serra-Pladevall J, DeOliveira RB, Granoff DM, and Ram S. Fusion protein comprising factor H domains 6 and 7 and human IgG1 Fc as an antibacterial immunotherapeutic. Clinical Vaccine and Immunology 2014;21:1452-1459. PubMed ID: 25143339.
PDF

Beernink PT, Shaughnessy J, Stefek H, Ram S and Granoff DM. Heterogeneity in rhesus macaque complement factor H binding to meningococcal factor H binding protein (FHbp) informs selection of primates to assess immunogenicity of FHbp-based vaccines. Clinical Vaccine and Immunology 2014;21:1505-1511. PubMed ID: 25185576.
PDF

CHAPTERS
Granoff DM, Pelton S, and Harrison LH. Meningococcal vaccines. In: Plotkin SA, Orenstein WA, and Offit PA, editors. Vaccines. 6th ed. Philadelphia: Saunders Elsevier; 2013. p 388-418.

Granoff DM and Gilsdorf JR. Neisseria meningitidis (Meningococcus). In:  Kliegman RM, Stanton B, St. Geme J, Schor N, and Behrman RE, editors. Nelson Textbook of Pediatrics. 19th ed. Philadelphia: Saunders Elsevier; 2012. p 929-935.

Revised: Thursday, March 16, 2017 10:01 AM

 


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