Medical Director, Pediatric Intensive Care Unit, Children’s Hospital Oakland

Phone: 510-428-3710

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“As most pediatric illness involves respiratory disease and infection, we focus on the epidemiology, diagnosis and treatment of neonatal and pediatric respiratory failure and the diagnosis, pathophysiology and treatment of overwhelming shock and infection (sepsis).”

Dr. Flori and the Pediatric Critical Care Clinical Research Group (PCCCR) investigate genetic predispositions to, and biomedical markers of, worse outcomes after lung injury and sepsis, and ways to improve the diagnosis and prediction of disease severity in pneumonia. The PCCCR group is currently involved in 14 active clinical research projects, of which 9 are federally funded. The research in pediatric intensive care has always centered on understanding the burden of critical illness as well as the mechanisms and pathophysiology of disease while also testing new strategies to improve morbidity and mortality. Additional research includes independent investigations in clinical decision support tools for use in a hospital electronic medical record and in the transport of critically ill children, in identifying risk factors for brain edema in pediatric diabetic ketoacidosis and in pediatric neurocritical care.

The PCCCR group also offers subspecialty training in pediatric critical care; part of such training involves fostering the independent interests of research fellows requirements. In support of such educational research, the PCCCR group has explored many new worlds such as medical ethics, transport and telemedicine, acupuncture, diabetes and racial disparities in pediatric critical care.

Finally, as there are fewer than 5000 pediatric critical care beds in the US compared to approximately 90,000 adult critical care beds, Dr. Flori realizes that the best opportunities to understand pediatric critical illnesses research are in collaboration. The PCCCR group participates in national and international collaborations with the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, UCSF Medical Center and the Cardiovascular Research Institute, San Francisco General Hospital, Cincinnati Children’s Hospital Medical Center, Children’s Hospital Boston, Stanford University and the Lucille Packard Children’s Hospital, NIH, Centers for Disease Control and Prevention (CDC), and the California Department of Health.

Revised: Friday, August 3, 2012 4:06 PM


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