Email: hfischer@chori.org
Phone: 510-450-7696

Email: billek@chori.org
Phone: 510-450-7699

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Publications

Fischer H, Illek B, Negulescu PA, Clauss W, Machen TE (1992) Carbachol-activated calcium entry into HT-29 cells is regulated by both membrane potential and cell volume. Proc Natl Acad Sci USA 89, 1438-1442. Abstract

Illek B, Fischer H, Kreusel KM, Hegel U, Clauss W (1992) Volume-sensitive basolateral K+ channels in HT-29/B6 cells: block by lidocaine, quinidine, NPPB, and Ba2+. Am J Physiol Cell Physiol 263, C674-C683. Abstract

Illek B, Fischer H, Machen TE (1992) Intracellular Ca2+ signalling is modulated by K+ channel blockers in colonic epithelial cells (HT-29/B6). Eur J Physiol - Pflügers Arch 422, 48-54.

Fischer H, Kreusel KM, Illek B, Machen TE, Hegel U, Clauss W (1992) The outwardly rectifying Cl channel is not involved in cAMP mediated Cl secretion in HT-29 cells: evidence for a very low conductance channel. Eur J Physiol - Pflügers Arch 422, 159-167.

Illek B, Fischer H, Clauss W (1993) Quinidine-sensitive K+ channels in the basolateral membrane of embryonic coprodeum epithelium: regulation by aldosterone and thyroxine. J Comp Physiol B 163, 556-562.

Poulsen JH, Fischer H, Illek B, Machen TE (1994) Bicarbonate conductance and a pH regulatory capability of CFTR. Proc Natl Acad Sci USA 91, 5360-5344. Abstract

Fischer H, Machen TE (1994) CFTR displays voltage dependence and two gating modes during stimulation. J Gen Physiol 104, 541-566. Abstract

Illek B, Fischer H, Santos GG, Widdicombe JH, Machen TE, Reenstra WW (1995) Cyclic-AMP independent activation of the CFTR Cl channel by the tyrosine kinase inhibitor genistein. Am J Physiol Cell Physiol 268, C886-C893.Abstract

Fischer H, Illek B, Machen TE (1995) The actin filament disrupter cytochalasin D activates the recombinant CFTR in 3T3 cells. J Physiol London 489, 745-754. Abstract

Illek B, Fischer H, Machen TE (1996) Alternate stimulation of apical CFTR by genistein in epithelia. Am J Physiol Cell Physiol 270, C265-C275 Abstract

Fischer H, Machen TE (1996) The tyrosine kinase p60c-src regulates the fast gate of the CFTR Cl channel. Biophys J 71, 3073-3082. Abstract

B Illek, JR Yankaskas, TE Machen (1997) cAMP and genistein stimulate HCO3- conductance through CFTR in human airway epithelia. Am J Physiol Lung Cell Mol Physiol, 272, 752 - 761. Abstract

Fischer H, Illek B, Machen TE (1998) Regulation of CFTR by protein phosphatase 2B and protein kinase C. Eur J Physiol - Pflugers Arch 436, 175-181.

Uyekubo SN, Fischer H, Maminishkis A, Illek B, Miller SS, Widdicombe JH (1998) cAMP-dependent absorption of chloride across airway epithelium. Am J Physiol Lung Cell Mol Physiol 275, L1219-L1227. Abstract

Zhang L, Wang D, Fischer H, Fan PD, Widdicombe JH, Kan YW, Dong JY (1998) Efficient expression of CFTR function with adeno-associated virus vectors that carry shortened CFTR genes. Proc Natl Acad Sci USA 95, 10158-10163. Abstract

Illek B, Fischer H (1998) Flavonoids stimulate Cl conductance of human airway epithelium in vitro and in vivo. Am J Physiol Lung Cell Mol Physiol 275, L902-L910. Abstract

Illek B, Tam AWK, Fischer H, Machen TE (1999) Anion selectivity of apical membrane conductance of Calu-3 human airway epithelium. Eur J Physiol - Pflugers Arch 437, 812-822.

Wang D, Fischer H, Zhang L, Fan P, Ding RX, Dong JY (1999) Efficient CFTR expression from AAV vectors packaged with promoters - the second generation. Gene Therapy 6, 667-675.

Illek B, Zhang L, Lewis N, Moss RB, Dong JY, Fischer H (1999) Defective function of the cystic fibrosis-causing missense mutation G551D is recovered by genistein. Am J Physiol Cell Physiol 277, C833-C839. Abstract

Biesalski HK, Frank J, Beck SC, Heinrich F, Illek B, Reifen R, Gollnick H, Seeliger MW, Wissinger B, and Zrenner E (1999) Biochemical but not clinical vitamin A deficiency results from mutations in the gene for retinol binding protein. Am. J. Clinical Nutrition, 69, 931 - 936. Abstract

Illek B, Lizarzaburu ME, Lee V, Nantz MH, Kurth MJ, Fischer H (2000) Structural determinants for activation and block of CFTR-mediated chloride currents by apigenin. Am J Physiol Cell Physiol 279, C1838-C1846. Abstract

Fischer H, Fukuda N, Barbry P, Illek B, Sartori C, Matthay MA (2001) Partial restoration of defective chloride conductance in DF508 CF mice by trimethylamine oxide. Am J Physiol Lung Cell Mol Physiol 281, L52-L57. Abstract

Fischer H, Widdicombe JH, Illek B (2002) Acid secretion and proton conductance in human airway epithelium. Am J Physiol Cell Physiol 282, 736-743. Abstract

Illek B, Fischer H, Machen TE, Widdicombe JH, Carlson TJS, Chow JWS. A novel extract from the bark latex of Croton lechleri inhibits cAMP-activated chloride secretion in human colonic epithelial cells. J Ethnopharmacology, in review.

Chung NC, Illek B, Widdicombe JH, Fischer H. (2003) Measurement of nasal potential difference in asthmatics. Chest 123, 1467-1471. Abstract

Howard M, Fischer H, Santos B, Gullans SR, Welch WJ. Mammalian osmolytes and S-nitrosoglutathione promote DF508 CFTR maturation and function. J Biol Chem, in review.

Schwarzer C, Machen TE, Illek B, Fischer H. Proton conductance and expression of Nox isoforms in airway epithelial cells. J Biol Chem, in review.


Reviews

Illek B, Fischer H, Machen TE (1998) Regulation of CFTR by small molecules including HCO3. Am J Physiol Gastrointest Liver Physiol 275, G1221-G1226. Abstract

Fischer H (2002) Electrophysiological approach to studying CFTR. In: Cystic Fibrosis Methods and Protocols. Ed. WR Skatch. Humana Press Inc., Totowa, 49-66.


Popular Science Articles

Illek B, Machen TE, Widdicombe JH, Fischer H (1998) Stimulation of cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel by flavonoids. Emerging Therapeutic Targets 2, 1-4.

Fischer, H (1998) Regulation of CFTR by kinases and phosphatases. CFRI News, Fall 1998, 1-2. pdf

Fischer H (2000) Noise analysis of patch clamp recordings. Axobits 28, 8-11. pdf

Fischer, H (2003) Acid secretion by the airways. CFRI News, Fall 2003, in press.


Cloned Genes

Schwarzer C, Machen TE, Illek B, Fischer H (2003) Homo sapiens NADPH oxidase 4 variant (Nox4) mRNA. GenBank Acc No. AY288918 pdf

 

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