HENRY A. ERLICH, PHD
Senior Scientist
An Overview
Research
Scientists & Staff
Publications
 

Email
Phone: 510-450-7932

 

 

Publications

Jin Y, Hayashi M, Fain PR, Suzuki T, Fukai K, Oiso N, Tanemura A, Holcomb CL, Rastrou M, Erlich HA, Spritz RA. Major association of vitiligo with HLA-A*02:01 in Japanese. Pigment Cell Melanoma Res. 2015 Jan 24. In Press.

Lin L, Ma C, Wei B, Aziz N, Rajalingam R, Yusung S, Erlich HA, Trachtenberg EA, Targan SR, McGovern DP, Heath JR, Braun J. Human NK cells licensed by killer Ig receptor genes have an altered cytokine program that modifies CD4+ T cell function. J Immunol. 2014 Jul 15;193(2):940-9.

Holcomb CL, Rastrou M, Williams TC, Goodridge D, Lazaro AM, Tilanus M, Erlich HA. Next-generation sequencing can reveal in vitro-generated PCR crossover products: some artifactual sequences correspond to HLA alleles in the IMGT/HLA database. Tissue Antigens. 2014 Jan;83(1):32-40.

Valdes AM, Varney MD, Erlich HA, Noble JA. Receiver operating characteristic analysis of HLA, CTLA4, and insulin genotypes for type 1 diabetes. Diabetes Care. 2013 Sep;36(9):2504-7.

Erlich HA, Valdes AM, Noble JA. Prediction of type 1 diabetes. Diabetes. 2013. Apr;62(4):1020-1.

Erlich HA, Valdes AM, McDevitt S, Simen BB, Blake LA, McGowan KR, Todd JA, Rich SS, Noble J. Next Generation Sequencing Reveals the Association of DRB3*02:02 with Type I Diabetes. Diabetes. 2013. 62(7):2618-22.

Rao A, Young S, Erlich H, Boyle S, Krevolin M, Sun R, Apple R, Behrens C. Development and Characterization of the cobas Human Papillomavirus Test. J Clin Microbiol. 2013 May;51(5):1478-84.

Moonsamy PV, Williams T, Bonella P, Holcomb CL, Höglund BN, Hillman G, Goodridge D, Turenchalk GS, Blake LA, Daigle DA, Simen BB, Hamilton A, May AP, Erlich HA.High throughput HLA genotyping using 454 sequencing and the Fluidigm Access Array™ system for simplified amplicon library preparation. Tissue Antigens. 2013 Mar;81(3):141-9.

De Santis D, Dinauer D, Duke J, Erlich HA, Holcomb CL, Lind C, Mackiewicz K, Monos D, Moudgil A, Norman P, Parham P, Sasson A, Allcock RJ. 16(th) IHIW : review of HLA typing by NGS. Int J Immunogenet. 2013 Feb;40(1):72-6.

Frederiksen B, Liu E, Romanos J, Steck AK, Yin X, Kroehl M, Fingerlin TE, Erlich H, Eisenbarth GS, Rewers M, Norris JM. Investigation of the vitamin D receptor gene (VDR) and its interaction with protein tyrosine phosphatase, non-receptor type 2 gene (PTPN2) on risk of islet autoimmunity and type 1 diabetes: The Diabetes Autoimmunity Study in the Young (DAISY). J Steroid Biochem Mol Biol. 2013. 133:51-7.

Urayama KY, Chokkalingam AP, Metayer C, Ma X, Selvin S, Barcellos LF, Wiemels JL, Wiencke JK, Taylor M, Brennan P, Dahl GV, Moonsamy P, Erlich HA, Trachtenberg E, Buffler PA. HLA-DP genetic variation, proxies for early life immune modulation and childhood acute lymphoblastic leukemia risk. Blood. 2012. 120(15):3039-47.

Howson JM, Cooper JD, Smyth DJ, Walker NM, Stevens H, She JX, Eisenbarth GS, Rewers M, Todd JA, Akolkar B, Concannon P, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Pociot F, Rich SS; and the Type 1 Diabetes Genetics Consortium. Evidence of Gene-Gene Interaction and Age-at-Diagnosis Effects in Type 1 Diabetes. Diabetes. 2012. 61(11):3012-7.

Valdes AM, Erlich HA, Carlson J, Varney M, Moonsamy PV, Noble JA. Use of class I and class II HLA loci for predicting age at onset of type 1 diabetes in multiple populations. Diabetologia. 2012 Sep;55(9):2394-401.

Erlich H. HLA DNA typing: past, present, and future. Tissue Antigens. 2012 Jul;80(1):1-11.

Baxter J, Vehik K, Johnson SB, Lernmark B, Roth R, Simell T; TEDDY Study Group. Differences in recruitment and early retention among ethnic minority participants in a large pediatric cohort: the TEDDY Study. Contemp Clin Trials. 2012 Jul;33(4):633-40.

Jin Y, Ferrara T, Gowan K, Holcomb C, Rastrou M, Erlich HA, Fain PR, Spritz RA. Next-generation DNA re-sequencing identifies common variants of TYR and HLA-A that modulate the risk of generalized vitiligo via antigen presentation. J Invest Dermatol. 2012 Jun;132(6):1730-3.

Noble JA, Erlich HA. Genetics of type 1 diabetes. Cold Spring Harb Perspect Med. 2012 Jan;2(1):a007732.

Skibola CF, Akers NK, Conde L, Ladner M, Hawbecker SK, Cohen F, Ribas F, Erlich HA, Goodridge D, Trachtenberg EA, Smith MT, Bracci PM. Multi-locus HLA class I and II allele and haplotype associations with follicular lymphoma. Tissue Antigens. 2012 Apr;79(4):279-86.

Cooper JD, Howson JM, Smyth D, Walker NM, Stevens H, Yang JH, She JX, Eisenbarth GS, Rewers M, Todd JA, Akolkar B, Concannon P, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Pociot F, Rich SS; Type 1 Diabetes Genetics Consortium. Confirmation of novel type 1 diabetes risk loci in families. Diabetologia. 2012 Apr;55(4):996-1000.

Hunt KA, Smyth DJ, Balschun T, Ban M, Mistry V, Ahmad T, Anand V, Barrett JC, Bhaw-Rosun L, Bockett NA, Brand OJ, Brouwer E, Concannon P, Cooper JD, Dias KR, van Diemen CC, Dubois PC, Edkins S, Fölster-Holst R, Fransen K, Glass DN, Heap GA, Hofmann S, Huizinga TW, Hunt S, Langford C, Lee J, Mansfield J, Marrosu MG, Mathew CG, Mein CA, Müller-Quernheim J, Nutland S, Onengut-Gumuscu S, Ouwehand W, Pearce K, Prescott NJ, Posthumus MD, Potter S, Rosati G, Sambrook J, Satsangi J, Schreiber S, Shtir C, Simmonds MJ, Sudman M, Thompson SD, Toes R, Trynka G, Vyse TJ, Walker NM, Weidinger S, Zhernakova A, Zoledziewska M; Type 1 Diabetes Genetics Consortium; UK Inflammatory Bowel Disease (IBD) Genetics Consortium; Wellcome Trust Case Control Consortium, Weersma RK, Gough SC, Sawcer S, Wijmenga C, Parkes M, Cucca F, Franke A, Deloukas P, Rich SS, Todd JA, van Heel DA. Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nat Genet. 2011 Dec 27;44(1):3-5.

Cano P, Mack SJ, Fernández-Viña M. The CWD allele catalog in China. Hum Immunol. 2012. 73(1):60.

Ivansson EL, Juko-Pecirep I, Erlich HA, Gyllensten UB. Pathway-based analysis of genetic susceptibility to cervical cancer in situ: HLA-DPB1 affects risk in Swedish women. Genes Immun. 2011. 12(8):605-14.

Holcomb CL, Höglund B, Anderson MW, Blake LA, Böhme I, Egholm M, Ferriola D, Gabriel C, Gelber SE, Goodridge D, Hawbecker S, Klein R, Ladner M, Lind C, Monos  D, Pando MJ, Pröll J, Sayer DC, Schmitz-Agheguian G, Simen BB, Thiele B, Trachtenberg EA, Tyan DB, Wassmuth R, White S, Erlich HA. A multi-site study using high-resolution HLA genotyping by next generation sequencing. Tissue Antigens. 2011 Mar;77(3):206-17.

Morahan G, Mehta M, James I, Chen WM, Akolkar B, Erlich HA, Hilner JE, Julier  C, Nerup J, Nierras C, Pociot F, Todd JA, Rich SS; for the Type 1 Diabetes Genetics Consortium. Tests for Genetic Interactions in Type 1 Diabetes: Linkage and Stratification Analyses of 4,422 Affected Sib-Pairs. Diabetes. 2011 Mar;60(3):1030-1040.

Galgani A, Valdes A, Erlich HA, Mano C, Cheng S, Petrone A, Sentinelli F, Berni A, Baroni MG, Buzzetti R. Homozygosity for the Ala allele of the PPARγ2 Pro12Ala polymorphism is associated with reduced risk of coronary artery disease. Dis Markers. 2010;29(5):259-64.

Stene LC, Oikarinen S, Hyöty H, Barriga KJ, Norris JM, Klingensmith G, Hutton  JC, Erlich HA, Eisenbarth GS, Rewers M. Enterovirus infection and progression from islet autoimmunity to type 1 diabetes: the Diabetes and Autoimmunity Study in the Young (DAISY). Diabetes. 2010 Dec;59(12):3174-80.

Noble JA, Valdes AM, Varney MD, Carlson JA, Moonsamy P, Fear AL, Lane JA, Lavant E, Rappner R, Louey A, Concannon P, Mychaleckyj JC, Erlich HA; Type 1 Diabetes Genetics Consortium. HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium. Diabetes. 2010 Nov;59(11):2972-9.

Mychaleckyj JC, Noble JA, Moonsamy PV, Carlson JA, Varney MD, Post J, Helmberg W, Pierce JJ, Bonella P, Fear AL, Lavant E, Louey A, Boyle S, Lane JA, Sali P, Kim S, Rappner R, Williams DT, Perdue LH, Reboussin DM, Tait BD, Akolkar B, Hilner JE, Steffes MW, Erlich HA; T1DGC. HLA genotyping in the international Type 1 Diabetes Genetics Consortium. Clin Trials. 2010;7(1 Suppl):S75-87.

Varney MD, Valdes AM, Carlson JA, Noble JA, Tait BD, Bonella P, Lavant E, Fear AL, Louey A, Moonsamy P, Mychaleckyj JC, Erlich H; Type 1 Diabetes Genetics Consortium. HLA DPA1, DPB1 alleles and haplotypes contribute to the risk associated with type 1 diabetes: analysis of the type 1 diabetes genetics consortium families. Diabetes. 2010 Aug;59(8):2055-62.

Pociot F, Akolkar B, Concannon P, Erlich HA, Julier C, Morahan G, Nierras CR,  Todd JA, Rich SS, Nerup J. Genetics of type 1 diabetes: what's next? Diabetes. 2010 Jul;59(7):1561-71. Review.

Hollenbach JA, Thompson SD, Bugawan TL, Ryan M, Sudman M, Marion M, Langefeld CD, Thomson G, Erlich HA, Glass DN. Juvenile idiopathic arthritis and HLA class I and class II interactions and age-at-onset effects. Arthritis Rheum. 2010 Jun;62(6):1781-91.

Marsh SG, Albert ED, Bodmer WF, Bontrop RE, Dupont B, Erlich HA, Fernández-Viña M, Geraghty DE, Holdsworth R, Hurley CK, Lau M, Lee KW, Mach B, Maiers M, Mayr WR, Müller CR, Parham P, Petersdorf EW, Sasazuki T, Strominger JL, Svejgaard A, Terasaki PI, Tiercy JM, Trowsdale J. Nomenclature for factors of the HLA system, 2010. Tissue Antigens. 2010 Apr;75(4):291-455. Review.

Morgan AW, Robinson JI, Conaghan PG, Martin SG, Hensor EM, Morgan MD, Steiner  L, Erlich HA, Gooi HC, Barton A, Worthington J, Emery P; UKRAG Consortium; YEAR Consortium. Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1,  PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort. Arthritis Res Ther. 2010;12(2):R57.

Marsh SG, Albert ED, Bodmer WF, Bontrop RE, Dupont B, Erlich HA, Fernández-Viña M, Geraghty DE, Holdsworth R, Hurley CK, Lau M, Lee KW, Mach B, Maiers M, Mayr WR, Müller CR, Parham P, Petersdorf EW, Sasazuki T, Strominger JL, Svejgaard A, Terasaki PI, Tiercy JM, Trowsdale J. An update to HLA nomenclature,  2010. Bone Marrow Transplant. 2010 May;45(5):846-8.

Rich SS, Akolkar B, Concannon P, Erlich H, Hilner JE, Julier C, Morahan G, Nerup J, Nierras C, Pociot F, Todd JA. Current status and the future for the genetics of type I diabetes. Genes Immun. 2009 Dec;10 Suppl 1:S128-31.

Rich SS, Akolkar B, Concannon P, Erlich H, Hilner JE, Julier C, Morahan G, Nerup J, Nierras C, Pociot F, Todd JA. Overview of the Type I Diabetes Genetics Consortium. Genes Immun. 2009 Dec;10 Suppl 1:S1-4.

Erlich HA, Valdes AM, Julier C, Mirel D, Noble JA; Type I Diabetes Genetics Consortium. Evidence for association of the TCF7 locus with type I diabetes. Genes Immun. 2009 Dec;10 Suppl 1:S54-9.

Erlich HA, Lohman K, Mack SJ, Valdes AM, Julier C, Mirel D, Noble JA, Morahan GE, Rich SS; Type I Diabetes Genetics Consortium. Association analysis of SNPs in the IL4R locus with type I diabetes. Genes Immun. 2009 Dec;10 Suppl 1:S33-41.

Erichsen MM, Løvås K, Skinningsrud B, Wolff AB, Undlien DE, Svartberg J, Fougner KJ, Berg TJ, Bollerslev J, Mella B, Carlson JA, Erlich H, Husebye ES. Clinical, immunological, and genetic features of autoimmune primary adrenal insufficiency: observations from a Norwegian registry. J Clin Endocrinol Metab. 2009 Dec;94(12):4882-90.

Trachtenberg E, Bhattacharya T, Ladner M, Phair J, Erlich H, Wolinsky S. The HLA-B/-C haplotype block contains major determinants for host control of HIV. Genes Immun. 2009 Dec;10(8):673-7

Bentley G, Higuchi R, Hoglund B, Goodridge D, Sayer D, Trachtenberg EA, Erlich HA. High-resolution, high-throughput HLA genotyping by next-generation sequencing. Tissue Antigens. 2009 Nov;74(5):393-403.

Hollenbach JA, Ladner MB, Saeteurn K, Taylor KD, Mei L, Haritunians T, McGovern DP, Erlich HA, Rotter JI, Trachtenberg EA. Susceptibility to Crohn's disease is mediated by KIR2DL2/KIR2DL3 heterozygosity and the HLA-C ligand. Immunogenetics. 2009 Oct;61(10):663-71.

Morgan AW, Thomson W, Martin SG; Yorkshire Early Arthritis Register Consortium, Carter AM; UK Rheumatoid Arthritis Genetics Consortium, Erlich HA, Barton A, Hocking L, Reid DM, Harrison P, Wordsworth P, Steer S, Worthington J, Emery P, Wilson AG, Barrett JH. Reevaluation of the interaction between HLA-DRB1  shared epitope alleles, PTPN22, and smoking in determining susceptibility to autoantibody-positive and autoantibody-negative rheumatoid arthritis in a large UK Caucasian population. Arthritis Rheum. 2009 Sep;60(9):2565-76. Erratum in: Arthritis Rheum. 2010 Oct;62(10):3005.

Moonsamy P, Bonella P, Goodwin G, Dolan L, Erlich HA; T1DGC. The identification of a new HLA-DPB1 allele (*1302) in one family and the detection of a recombination event between the DR and the DQ regions in another Caucasian T1DGC family. Tissue Antigens. 2009 Sep;74(3):268-70. Erratum in: Tissue Antigens. 2009 Oct;74(4):367.

Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier  C, Morahan G, Nerup J, Nierras C, Plagnol V, Pociot F, Schuilenburg H, Smyth DJ,  Stevens H, Todd JA, Walker NM, Rich SS; Type 1 Diabetes Genetics Consortium. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet. 2009 Jun;41(6):703-7.

Baschal EE, Aly TA, Jasinski JM, Steck AK, Noble JA, Erlich HA, Eisenbarth GS; Type 1 Diabetes Genetics Consortium. Defining multiple common "completely" conserved major histocompatibility complex SNP haplotypes. Clin Immunol. 2009 Aug;132(2):203-14.

Steck AK, Zhang W, Bugawan TL, Barriga KJ, Blair A, Erlich HA, Eisenbarth GS, Norris JM, Rewers MJ. Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes? Diabetes. 2009 Apr;58(4):1028-33.

Baschal EE, Aly TA, Jasinski JM, Steck AK, Johnson KN, Noble JA, Erlich HA, Eisenbarth GS; Type 1 Diabetes Genetics Consortium. The frequent and conserved DR3-B8-A1 extended haplotype confers less diabetes risk than other DR3 haplotypes. Diabetes Obes Metab. 2009 Feb;11 Suppl 1:25-30.

Rich SS, Akolkar B, Concannon P, Erlich H, Hilner J, Julier C, Morahan G, Nerup J, Nierras C, Pociot F, Todd JA. Results of the MHC fine mapping workshop. Diabetes Obes Metab. 2009 Feb;11 Suppl 1:108-9.

Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium. Concannon P, Chen WM, Julier C, Morahan G, Akolkar B, Erlich HA, Hilner JE, Nerup J, Nierras C, Pociot F, Todd JA, Rich SS; Type 1 Diabetes Genetics Consortium. Diabetes. 2009 Apr;58(4):1018-22.

Wang X, Cheng S, Brophy VH, Erlich HA, Mannhalter C, Berger K, Lalouschek W, Browner WS, Shi Y, Ringelstein EB, Kessler C, Luedemann J, Lindpaintner K, Liu L, Ridker PM, Zee RY, Cook NR. A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients. RMS Stroke SNP Consortium.
Stroke. 2009 Mar;40(3):683-95.

TEDDY Study Group. The Environmental Determinants of Diabetes in the Young (TEDDY) Study. Ann N Y Acad Sci. 2008 Dec;1150:1-13.

Atik B, Skwor TA, Kandel RP, Sharma B, Adhikari HK, Steiner L, Erlich H, Dean D. Identification of novel single nucleotide polymorphisms in inflammatory genes as risk factors associated with trachomatous trichiasis. PLoS One. 2008;3(10):e3600.

Yee LJ, Im K, Wahed AS, Bugawan T, Li J, Rhodes SL, Erlich H, Rosen HR, Liang TJ, Yang H; Virahep-C Study. Polymorphism in the human major histocompatibility complex and early viral decline during treatment of chronic hepatitis C. Antimicrob Agents Chemother. 2009 Feb;53(2):615-21.

Tranah GJ, Taylor BC, Lui LY, Zmuda JM, Cauley JA, Ensrud KE, Hillier TA, Hochberg MC, Li J, Rhees BK, Erlich HA, Sternlicht MD, Peltz G, Cummings SR; Study of Osteoporotic Fractures (SOF) Research Group.  Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fractures. Calcif Tissue Int. 2008 Sep;83(3):155-66.

Ivansson EL, Magnusson JJ, Magnusson PK, Erlich HA, Gyllensten UB. MHC loci affecting cervical cancer risk: distinguishing the effects of HLA-DQB1 and non-HLA genes TNF, LTA, TAP1 and TAP2. Genes Immun. 2008 Oct;9(7):613-23.

A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3.
Concannon P, Onengut-Gumuscu S, Todd JA, Smyth DJ, Pociot F, Bergholdt R, Akolkar B, Erlich HA, Hilner JE, Julier C, Morahan G, Nerup J, Nierras CR, Chen WM, Rich SS; Type 1 Diabetes Genetics Consortium.
Diabetes. 2008 Oct;57(10):2858-61.

Noble JA, Martin A, Valdes AM, Lane JA, Galgani A, Petrone A, Lorini R, Pozzilli P, Buzzetti R, Erlich HA. Type 1 diabetes risk for human leukocyte antigen (HLA)-DR3 haplotypes depends on genotypic context: association of DPB1 and HLA class I loci among DR3- and DR4-matched Italian patients and controls.
Hum Immunol. 2008 Apr-May;69(4-5):291-300.

Erlich H, Valdes AM, Noble J, Carlson JA, Varney M, Concannon P, Mychaleckyj JC, Todd JA, Bonella P, Fear AL, Lavant E, Louey A, Moonsamy P. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Type 1 Diabetes Genetics Consortium. Diabetes. 2008 Apr;57(4):1084-92.

Rhodes SL, Erlich H, Im KA, Wang J, Li J, Bugawan T, Jeffers L, Tong X, Su X, Rosen HR, Yee LJ, Liang TJ, Yang H; Virahep-C Study Group. Associations between the human MHC and sustained virologic response in the treatment of chronic hepatitis C virus infection. Genes Immun. 2008 Jun;9(4):328-33.

Aly TA, Baschal EE, Jahromi MM, Fernando MS, Babu SR, Fingerlin TE, Kretowski A, Erlich HA, Fain PR, Rewers MJ, Eisenbarth GS. Analysis of single nucleotide polymorphisms identifies major type 1A diabetes locus telomeric of the major histocompatibility complex. Diabetes. 2008 Mar;57(3):770-6.





Revised: Friday, March 6, 2015 2:07 PM

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