Publications

Peer-Reviewed Publications (21ST Century)        

• Vichinsky EP, Neumayr LD, Earles AN, Williams R, Lennette ET, Dean D, Nickerson B, McKie V, Bellevue R, Daeschner C, Aboud M, Orringer E, Moncino M, Ware R, Ballas SK, Manci-Gardener E, Etiology and natural history of acute chest syndrome: Report of the National acute chest syndrome study. NEJM 2000;342:1855-65.
• Plank R, and Dean D. Overview of the Epidemiology, Microbiology, and Pathogenesis of Leptospira spp. in Humans. Microbes and Infection 2000; 2:1265-76.
• Dean D, Suchland R, and Stamm W. Apparent long-term persistence of Chlamydia trachomatis cervical infections - analysis by omp1 genotyping. J Infect Dis 2000; 182:909-16.
• Dean D and VC Powers. Persistent Chlamydia trachomatis Infections Resist Apoptotic Stimuli. Infect Immun 2001;69:2442-7.
• Hessel T, Dhital SP, Plank R, and Dean D. Immune response to chlamydial 60-kilodalton heat shock protein in tears from Nepali trachoma patients. Infect Immun 2001;69:4996-5000
• Millman K, Tavere S, and Dean D. Recombination in the ompA gene but not the omcB gene of Chlamydia contribute to serovar specific differences in tissue tropism, immune surveillance and persistence of the organism. J Bacteriol 2001; 183:5997-6008.
• Johnston SC, Messina LM, Browner WS, Morris C, and Dean D. C-Reactive Protein and Viable Chlamydia pneumoniae in Carotid Artery Atherosclerosis. Stroke 2001; 32:2748-2752.
• Dean D, Suchland R, and Stamm W. Persistence of Chlamydia trachomatis infections. J Infect Dis 2001; 184:1632-4.
• Dean D, Neumayr L, Kleman K, and Vichinsky E. Chlamydia pneumoniae infections in acute chest syndrome patients with sickle cell disease. J of Ped Hem/Onc 2003;25:46-55.
• Frick K, Colchero MA, and Dean D. Modeling the Economic Net Benefit of a Potential Vaccination Program Against Ocular Infection with Chlamydia trachomatis. Vaccine 2003;22:690-7.
• Millman K, Black CM, JohnsonR, Stamm WE, Jones R, Hook E, Martin D, Bolan G, Tavaré S,and Dean D. Population-based Genetic and Evolutionary Analysis of Chlamydia trachomatis Urogenital Strain Variation in the United States. J Bacteriol 2004;186:2457-65..
• Shrier LA. Dean D. Klein E. Harter K. and Rice PA. Limitations of screening tests for the detection of Chlamydia trachomatis in asymptomatic adolescent and young adult women. American Journal of Obstetrics & Gynecology. 204;190:654-62.
• Zhang H, Kandel RP, Sharma B, and Dean D. Ocular Chlamydia trachomatis infection is a risk factor for postoperative recurrence of trachomatous trichiasis: implications for the prevention of trachomatous blindness. Archives of Ophthalmol 2004;122:511-6.
• Gomes JP, Bruno WJ, Borrego MJ, and Dean D. Recombination in the genome of Chlamydia trachomatis involving the polymorphic membrane protein C relative to ompA and evidence for horizontal gene transfer. J Bacteriol 2004: 186:4295-306.
• Gomes JP, Hsia R-c, Mead S, Borrego MJ, and Dean D. Immunoreactivity and differential developmental expression of known and putative Chlamydia trachomatis membrane proteins for biologically variant serovars representing distinct disease groups. Microbes Infect 2005;7:410-20.
• Hsieh JC, Tham DM, Feng W, Huang F, Embaie S, Liu K, Dean D, FitzGerald DJ and Mrsny RJ. An Intranasal Immunization Strategy to Impede Pilin-Mediated Binding of Pseudomonas aeruginosa to Airway Epithelial Cells and Neutralize Cytotoxic Actions of this Pathogen. Infect Immun 2005;73;7705-7717.
• Johnston SC, Zhang H, Messina LM, Lawton MT and Dean D. Burden of Chlamydia pneumoniae Infection in Carotid Arteries is Associated with Up Regulation of Plaque IL-6 and Elevated Serum Levels of C-Reactive Protein. Arterioscler, Thromb Vasc Biol 2005;25:2648-53.
• Gomes JP, Borrego MJ, Atik B, Santo I, Azevedo J, Brito de Sá A, Nogueira P, and Dean D. Correlating Chlamydia trachomatis infectious load with urogenital ecological success and disease pathogenesis. Microbes Infect 2006;8:16-26.
• Gomes JP, Bruno WJ, Borrego MJ, Nunes A, Florindo C, and Dean D. Polymorphisms in the nine polymorphic membrane proteins of Chlamydia trachomatis across all serovars: Evidence for Da recombination and correlation with tissue tropism. J Bacteriol 2006;188:275-86.
• Millman K, Black CM, Stamm WE, Jones R, Hook E, Martin D, Bolan G, Tavaré S, and Dean D. Population-based genetic epidemiologic analysis of Chlamydia trachomatis serotypes and ompA polymorphisms associated with clinical phenotypes. Microbes Infect 2006; 8:604-11.
• Zhang H, Kandel RP, Atakari HK, and Dean D. Oral Azithromycin Significantly Reduces the Postoperative Recurrence of Trachomatous Trichiasis. Br J Ophthalmol 2006;90:943-948.
• Atik B, Thanh TTK, Luong VQ , Lagree S, and Dean D. Impact of Annual Targeted Treatment on Infectious Trachoma and Susceptibility to Reinfection. JAMA 2006; 296:1488-97.
• Gomes JP, Bruno WJ, Nunes A, Santos N, Florindo C, Borrego MJ, and Dean D. Evolution of Chlamydia trachomatis Diversity Occurs by Widespread Interstrain Recombination Involving Hotspots. Genome Research  2006;Nov.7 online in advance of print;2007;1:50-60.
• Liu Z, Rank R, Kaltenboek B, Magnino S, Dean D, Plaut R, Read T, Myers G, and Bavoil, P.M. Genomic plasticity of the rrn-nqrF intergenic segment in the Chlamydiaceae.  J Bacteriol  2007;189;2128-2132.
• Dean D, Atik B, Thanh TT, Luong VQ, and Lagree S. Evaluating the “A” component of the SAFE strategy.  Lancet Infectious Diseases  2007;7:2-3.

  Book Chapters and Books (21ST Century)
  Dean D. Pathogenesis of Chlamydial Ocular Infections. In: Duane’s Foundations of Clinical Ophthalmology. Tasman W, and Jaeger EA, eds. Lippincott Williams & Wilkins, Philadelphia, PA. 2002;Volume 2; Chapter 77.; pgs 1-20.
  
  Dean D, Myers G, and Read T. Lessons and challenges arising from the “first wave” of chlamydial genomics. In: Chlamydia: Genomics, Pathogenesis and Implications for Control. Editors: Patrik Bavoil and Priscilla Wyrick. Horizon Scientific Press, Norwich, UK. 2006. Chpt. 1; pages1-24.
  
  Dean D and Millman K.  The Evolution of Chlamydiaceae and Chlamydiaceae Infections.  In: Introduction to Evolutionary Biology of Bacterial and Fungal Pathogens.  Baquero F, Nombell C, Cassell GH, Gutierrez JA, eds.  Elsevier Press, 2007: In Press
  
  Dean D and Read T. Comparative and functional genomics for Chlamydia trachomatis: A global understanding of the pathogenesis of ocular and sexually transmitted diseases with public health implications.