Publications

Peer-Reviewed Publications (21ST Century)        

• Vichinsky EP, Neumayr LD, Earles AN, Williams R, Lennette ET, Dean D, Nickerson B, McKie V, Bellevue R, Daeschner C, Aboud M, Orringer E, Moncino M, Ware R, Ballas SK, Manci-Gardener E, Etiology and natural history of acute chest syndrome: Report of the National acute chest syndrome study. NEJM 2000;342:1855-65.
• Plank R, and Dean D. Overview of the Epidemiology, Microbiology, and Pathogenesis of Leptospira spp. in Humans (peer reviewed review). Microbes and Infection 2000; 2:1265-76.
• Dean D, Suchland R, and Stamm W. Apparent long-term persistence of Chlamydia trachomatis cervical infections - analysis by omp1 genotyping. Journal of Infectious Diseases 2000; 182:909-16.
• Dean D and VC Powers. Persistent Chlamydia trachomatis Infections Resist Apoptotic Stimuli. Infection and Immunity 2001;69:2442-7.
• Hessel T, Dhital SP, Plank R, and Dean D. Immune response to chlamydial 60-kilodalton heat shock protein in tears from Nepali trachoma patients. Infection and Immunity 2001;69:4996-5000
• Millman K, Tavere S, and Dean D. Recombination in the ompA gene but not the omcB gene of Chlamydia contribute to serovar specific differences in tissue tropism, immune surveillance and persistence of the organism. Journal of Bacteriology 2001; 183:5997-6008.
• Johnston SC, Messina LM, Browner WS, Morris C, and Dean D. C-Reactive Protein and Viable Chlamydia pneumoniae in Carotid Artery Atherosclerosis. Stroke 2001; 32:2748-2752.
• Dean D, Suchland R, and Stamm W. Persistence of Chlamydia trachomatis infections. Journal of Infectious Diseases 2001; 184:1632-4.
• Dean D, Neumayr L, Kleman K, and Vichinsky E. Chlamydia pneumoniae infections in acute chest syndrome patients with sickle cell disease. Journal of Pediatric Hemotology and Oncology 2003;25:46-55.
• Frick K, Colchero MA, and Dean D. Modeling the Economic Net Benefit of a Potential Vaccination Program Against Ocular Infection with Chlamydia trachomatis. Vaccine 2003;22:690-7.
• Millman K, Black CM, Johnson R, Stamm WE, Jones R, Hook E, Martin D, Bolan G, Tavaré S, and Dean D. Population-based Genetic and Evolutionary Analysis of Chlamydia trachomatis Urogenital Strain Variation in the United States. Journal of Bacteriology 2004;186:2457-65..
• Shrier LA. Dean D. Klein E. Harter K. Rice PA. Limitations of screening tests for the detection of Chlamydia trachomatis in asymptomatic adolescent and young adult women. American Journal of Obstetrics and Gynecology 2004;190:654-62.
• Gomes JP, Bruno WJ, Borrego MJ, and Dean D. Recombination in the genome of Chlamydia trachomatis involving the polymorphic membrane protein C relative to ompA and evidence for horizontal gene transfer. Journal of Bacteriology 2004: 186:4295-306
• Zhang H, Kandel RP, Sharma B, and Dean D. Ocular Chlamydia trachomatis infection is a risk factor for postoperative recurrence of trachomatous trichiasis: implications for the prevention of trachomatous blindness. Archives of Ophthalmology 2004;122:511-6.
• Gomes JP, Hsia R-c, Mead S, Borrego MJ, and Dean D. Immunoreactivity and differential developmental expression of known and putative Chlamydia trachomatis membrane proteins for biologically variant serovars representing distinct disease groups. Microbes and Infection 2005;7:410-20.
• Hsieh JC, Tham DM, Feng W, Huang F, Embaie S, Liu K, Dean D, FitzGerald DJ and Mrsny RJ. An Intranasal Immunization Strategy to Impede Pilin-Mediated Binding of Pseudomonas aeruginosa to Airway Epithelial Cells and Neutralize Cytotoxic Actions of this Pathogen. Infection and Immunity 2005;73;7705-7717.
• Johnston SC, Zhang H, Messina LM, Lawton MT and Dean D. Burden of Chlamydia pneumoniae Infection in Carotid Arteries is Associated with Up Regulation of Plaque IL-6 and Elevated Serum Levels of C-Reactive Protein. Arteriosclerosis Thrombosis and Vascular Biology 2005;25:2648-53.
• Gomes JP, Borrego MJ, Atik B, Santo I, Azevedo J, Brito de Sá A, Nogueira P, and Dean D. Correlating Chlamydia trachomatis infectious load with urogenital ecological success and disease pathogenesis. Microbes and Infection 2006;8:16-26.
• Gomes JP, Bruno WJ, Borrego MJ, Nunes A, Florindo C, and Dean D. Polymorphisms in the nine polymorphic membrane proteins of Chlamydia trachomatis across all serovars: Evidence for Da recombination and correlation with tissue tropism. Journal of Bacteriology 2006;188:275-86.
• Millman K, Black CM, Stamm WE, Jones R, Hook E, Martin D, Bolan G, Tavaré S, and Dean D. Population-based genetic epidemiologic analysis of Chlamydia trachomatis serotypes and ompA polymorphisms associated with clinical phenotypes. Microbes and Infection 2006; 8:604-11.
• Zhang H, Kandel RP, Atakari HK, and Dean D. Oral Azithromycin Significantly Reduces the Postoperative Recurrence of Trachomatous Trichiasis. British Journal of Ophthalmology 2006;90:943-948.
• Atik B, Thanh TTK, Luong VQ , Lagree S, and Dean D. Impact of Annual Targeted Treatment on Infectious Trachoma and Susceptibility to Reinfection. JAMA 2006; 296:1488-97.
• Gomes JP, Bruno WJ, Nunes A, Santos N, Florindo C, Borrego MJ, and Dean D. Evolution of Chlamydia trachomatis Diversity Occurs by Widespread Interstrain Recombination Involving Hotspots. Genome Research ;2007;1:50-60.
• Liu Z, Rank R, Kaltenboek B, Magnino S, Dean D, Plaut R, Read T, Myers G, and Bavoil, P.M. Genomic plasticity of the rrn-nqrF intergenic segment in the Chlamydiaceae. Journal of Bacteriology 2007;189;2128-2132.
• Dean D, Atik B, Thanh TT, Luong VQ, and Lagree S. Evaluating the “A” component of the SAFE strategy. Lancet Infectious Diseases 2007;7:2-3.
• Nunes A, Gomes JP, Mead S, Florindo C, Correia H, Borrego MJ and Dean D. Comparative Expression Profiling of the Chlamydia trachomatis pmp Gene Family for Clinical and Reference Strains. PLoS One 2007; 2:e878 doi:10.1371/journal.pone.0000878.
• Wang A and Dean D. Apoptosis, Cell Signaling and Human Diseases: Molecular Mechanisms. JAMA 2007;298:2203-4.
• Dean D, Kandel RP, Atakari HK , and Hessel T. Multiple Chlamydiaceae Species in Trachoma: Implications for Disease Pathogenesis and Control. PLoS Medicine 2008; 5:e14 (PMID: 18177205).
• Somboonna N, Mead S, Lui J and Dean D. Differentiating new and emerging clonal populations of Chlamydia trachomatis reference and clnical strains by a novel shotgun cell culture harvest assay. Emerging Infectious Diseases 2008;14:445-53 (PMID: 18325260).
• Skwor T, Atik B, Kandel RP, Atakari HK, and Dean D. Role of Secreted Conjunctival Mucosal Cytokine and Chemokine Proteins in Different Stages of Trachomatous Disease. PLoS Neglected Tropical Diseases 2008; 2:e264. (PMID: 18628987)
• Atik B, Skwor TA, Kandel RP, Atakari HK, Steiner L, Erlich H and Dean D. Identification of Novel Single Nucleotide Polymorphisms in Inflammatory Genes as Risk Factors Associated with Trachomatous Trichiasis. PLoS One 2008;3:e3600. (PMCID: 2572999)
• Tan C, Hsia R, Shou H, Haggarty C, Gaydos C, Dean D, Scurlock A, Wilson DP, and Bavoil PM. C. trachomatis-infected patients display variable antibody profiles against the nine-member polymorphic membrane protein family. Infection and Immunity 2009;77:3218-26.
• Dean D, Bruno WJ, Wan R, Gomes JP, Devignot S, Mehari T, Servaas A. Morre, Myers G, Read TD, and Spratt BG. Predicting Phenotype and Emerging Strains among Chlamydia trachomatis Infections. Emerging Infectious Diseases 2009;15:1385-94.
• Dean D. Chlamydia trachomatis today: treatment, detection, immunogenetics and the need for a greater global understanding of chlamydial disease pathogenesis. Drugs Today. 2009: In press.
• Dean D. Psitacosis Monograph. British Medical Journal. 2009; In press.

Book Chapters and Books

1. Dean D. Molecular characterization of new Chlamydia trachomatis serological variants from a trachoma endemic region of Africa. In: Chlamydial Infections. Orfila J, et al. eds. Societa Editrice Esculapio, Bologna; 1994; pp. 259-62.
2. Weinstock HS, Dean D, Bolan G. Chlamydia trachomatis Infections. In: Sexually Transmitted Diseases in the AIDS Era; Part II. Infectious Disease Clinics of North America; WB Saunders, Philadelphia; 1994. pg. 797-819.
3. Dean D. Chlamydia trachomatis Sexually Transmitted Diseases. In: Pathology of Infectious Diseases. Connor DH, Schwartz DA, Chandler FW, eds. Appleton and Lange Publishers, Stamford, Conn. 1997: pgs 473-90
4. Dean D. Trachoma. In: Pathology of Infectious Diseases. Connor DH, Schwartz DA, Chandler FW, eds. Appleton and Lange Publishers, Stamford, Conn. 1997: pgs 498-507
5. Dean b. Typing of Chlamydia trachomatis. In: Molecular Protocols for Sexually Transmitted Diseases. Methods in Molecular Medicine Series. Peeling R, Sparling PF, eds. Humana Press, Inc, Totowa, NJ. 1999;pgs 151-70.
6. Dean D. Pathogenesis of Chlamydial Ocular Infections. In: Duane’s Foundations of Clinical Ophthalmology. Tasman W, and Jaeger EA, eds. Lippincott Williams & Wilkins, Philadelphia, PA. 2002;Volume 2; Chapter 77; pgs 1-20.
7. Dean D, Myers G, and Read T. Lessons and challenges arising from the “first wave” of chlamydial genomics. In: Chlamydia: Genomics, Pathogenesis and Implications for Control. Editors: Patrik Bavoil and Priscilla Wyrick. Horizon Scientific Press, Norwich, UK. 2006; Chapter 1; pgs 1-24.
8. Dean D and Millman K. The Evolution of Chlamydiaceae and Chlamydiaceae Infections. In: Evolutionary Biology of Bacterial and Fungal Pathogens. Baquero F, Nombell C, Cassell GH, Gutierrez JA, eds. ASM Press, Washington D.C. 2007:Chpt 40; pgs 475-488.
9. Somboonna N and Dean D. Limited genomes and gene transfer in the evolution of intracellular parasitism and symbiosis. In: Intracellular Niches of Pathogens – A Microbe’s Guide through the Host Cell. Editors: Schaible UE and Haas A. Wiley-VCH Publishers. 2009; Part 1, General Aspects, 2, ; pgs 21-32.
10. Skwor T and Dean D. Molecular approaches to typing chlamydiae. In: Molecular typing in bacterial infections. Eds: McKee ML and de Filppis I, Humana Press, Inc. 2009; In Press.
11. Dean D. Pathogenesis of Chlamydial Ocular Infections. In: Duane’s Foundations of Clinical Ophthalmology. Tasman W, and Jaeger EA, eds. Lippincott Williams & Wilkins, Philadelphia, PA. 2010;In Press

revised: Friday, November 6, 2009 4:22 PM