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Dario Boffelli, PhD, utilizes computational comparative genomic and experimental approaches to define the role of sequence variation in gene regulatory sequences in both human disease and evolution. Current research is focussed on two different approaches. The first is to compare the genomes of primate and non-primate species as a novel method of identifying regulatory sequences unique to the primate lineage, with a focus on the regulation of genes involved in lipid metabolism. The second is focused on improving our understanding of the role of sequence variation in the human genome to explain the genetic basis of disease.
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