Peter

PETER BEERNINK, PhD
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PUBLICATIONS

Peer-reviewed Articles (2014-2017)

López-Sagaseta J, Beernink PT, Bianchi F, Santini L, Frigimelica E, Lucas AH, Pizza M and Bottomley MJ (2017) Co-crystal structure of a vaccine-elicited cross-reactive and bactericidal human antibody reveals a conserved epitope target on meningococcal fHbp. Nature Communications (in press)

Endrizzi J and Beernink PT (2017) Charge neutralization in the active site of the catalytic trimer of aspartate transcarbamoylase promotes diverse structural changes. Protein Science 26:2221-2228. PubMed ID: 28833948

Malito E, Lo Surdo P, Veggi D, Santini L, Stefek H, Brunelli B, Luzzi E, Bottomley MJ, Beernink PT and Scarselli M (2016) Neisseria meningitidis Factor H binding protein bound to monoclonal antibody JAR 5: implications for antibody synergy. Biochemical Journal 473: 4699-4713. PubMed ID: 27784765

Granoff DM, Giuntini S, Gowans A, Lujan E, Sharkey K and Beernink PT (2016) Enhanced protective antibody to a mutant meningococcal Factor H-binding protein with low Factor H binding. Journal of Clinical Investigation Insight 1(14): e88907. PubMed ID: 27668287

Giuntini S, Granoff DM, Beernink PT, Ihle O, Bratlie D, Michaelsen TE (2016) Human IgG1, IgG3 and IgG3 hinge truncated mutants show different protection capability against meningococci depending on the target antigen and epitope specificity.
Clinical and Vaccine Immunology 23(8): 698-706. PubMed ID: 27307451

Rossi R, Konar M and Beernink PT (2016) Meningococcal Factor H binding protein vaccine antigens with increased thermal stability and decreased binding of human Factor H. Infection and Immunity. 84: 1735-1742. PubMed ID: 27021245

Giuntini S, Beernink PT and Granoff DM (2015) Effect of complement Factor H on anti-FHbp serum bactericidal antibody responses of infant rhesus macaques boosted with a licensed meningococcal serogroup B vaccine. Vaccine 33: 7168-7175. PubMed ID: 26562320

Konar M, Pajon R and Beernink PT (2015) A meningococcal vaccine antigen engineered to increase thermal stability and stabilize protective epitopes. Proceedings of the National Academy of Sciences U.S.A. 112: 14823-14828. PubMed ID: 26627237

Rossi R, Beernink PT, Giuntini S and Granoff DM (2015) Susceptibility of meningococcal strains responsible for two serogroup B outbreaks on U.S. university campuses to serum bactericidal activity elicited by the MenB-4C vaccine. Clinical and Vaccine Immunology 22: 1227-1234. PubMed ID: 26424832

Konar M, Beernink PT and Granoff DM (2015) A newly-identified polymorphism in rhesus macaque complement Factor H modulates binding affinity for meningococcal FHbp. PLOS ONE 10: e0135996. PubMed ID: 26285122

Granoff DM, Costa I, Konar M, Giuntini S, Van Rompay KKA and Beernink PT (2015) Binding of complement Factor H decreases protective anti-FHbp antibody responses of infant rhesus macaques immunized with a meningococcal serogroup B vaccine. Journal of Infectious Diseases 212: 784-792 PubMed ID: 25676468

Beernink PT, Giuntini S, Costa I, Lucas AH, Granoff DM (2015) Functional analysis of the human antibody response to meningococcal Factor H binding protein. mBio 6: e00842-15. PubMed ID: 26106082

Konar M, Rossi R, Walter H, Pajon R and Beernink PT (2015) A mutant library approach to identify improved meningococcal Factor H binding protein vaccine antigens. PLOS ONE 10: e0128185. PubMed ID: 26057742

Beernink PT, Shaughnessy J, Stefek H, Ram S and Granoff DM (2014) Heterogeneity in rhesus macaque complement Factor H binding to meningococcal Factor H binding protein (FHbp) informs selection of primates to assess immunogenicity of FHbp-based vaccines. Clinical and Vaccine Immunology 21: 1505-1511. PubMed ID: 25185576

Peer-reviewed Articles (1992-2013)

Earlier peer-reviewed publications can be found here.

Book Chapters

Coleman, M.A., Hoeprich, P., Beernink, P. and Camarero, J.A. (2007) Cell-Free Protein Expression Screening and Protein Immobilization Using Protein Microarrays. In Cell-Free Protein Expression. Kudlicki, W., Katzen, F and Bennett, R., eds. Landes Bioscience, Austin, TX.

Coleman, M.A., Beernink, P.T., Camarero, J.A. and Albala, J.S. (2007) Applications of functional protein microarrays: identifying protein-protein interactions in an array format. In Microchip-Based Assay Systems, Floriano, P. N.(ed)., Methods in Molecular Biology 385: 121-30. Humana Press, New York. PubMed ID: 18365708

Alber, T., Endrizzi, J.A., Schachman, H.K. and Beernink, P.T. (2006) Binding of bisubstrate analog promotes large structural changes in the unregulated catalytic trimer of aspartate transcarbamoylase: Implications for allosteric regulation. Rendiconti Lincei 17: 133-145. Springer, Milan.

Beernink, P.T., Segelke, B.W. and Coleman, M. A. (2003) Application of cell-free expression systems to proteomic studies. In Cell-Free Protein Expression, Swartz, J.R., (Ed.) Springer, Berlin.

 

 

Revised: Thursday, December 14, 2017 2:13 PM

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