Recent Selected Publications

1. McCann, J., and Ames, BN. (2006) Letter to the Editor (Response to P. Wainwright):  Scientific Precision and Deciding Whether to Supplement Infant Formulas With LCPUFAs, Am J Clin Nutr., 83: 920-1.

2. Walter, P., Macklin, E., Porter, J., Evans, P., Coates, T., Olivieri, N.F., Giardina, P., Kwiatkowski, J., Neufeld, E., Ames, B.N., Holland, J., Marks, P., Vichinsky, E., Harmatz, P. (2005) Abstract: Control of Oxidant-Stress and Inflammation by Iron Chelators Deferasirox (ICL670) or Deferoxamine in -Thalassemia: An Ancillary Study of the Novartis CICL670A0107 trial. American Society of Hematology 47th Annual Meeting.

3. Lal, A., Bhagat, A., Atamna, W., Offer, T., Vichinsky, E.P., Kuypers, F.A., Ames, B.N. (2005) Abstract: Increased Chromosomal Breaks in Sickle Cell Disease as Evidenced by the Presence of Micronuclei in Erythocytes. American Society of Hematology 47th Annual Meeting

4. Atamna, H and Boyle, K. (2006) Amyloid-b peptide binds with heme to form a peroxidase: Relationship to the cytopathologies of Alzheimer's disease. PNAS 103: 3381-6.

5. Lal, A., Suh, J.H., Ames, B.N. (2005) Abstract: Efficacy of Alpha-lipoic Acid in Iron-induced Oxidative Stress. American Society of Hematology 47th Annual Meeting

6. Zhang H, Liu J, Ao N, Yao D, Yan B, Jia H, Jia L, Ames BN, Liu J. (2006) R-a–Lipoic acid and acetyl-L-carnitine, and their synergistic combination prevent mitochondrial dysfunction and oxidative damage in a rotenone-treated human neuroblastoma cellular model of Parkinson’s disease (mitochondrial membrane potential/mitochondrial complex I/a-synuclein/ubiquitin/protein oxidation/oxidative DNA damage)

7. Liu, J and Ames, BN (2005) Review:  Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Nutritional Neuroscience, 8:67-89.

8. Kadiiska, M.B., Gladen, B.C., Baird, D.D., Germolec, D., Graham, L.B., Parker, C.E., Nyska, A., Wachsman, J.T., Ames, B.N, Basu S., Brot, N., FitzGerald, G.A., Floyd, R.A., George, M., Heinecke, J.W., Hatch, G.E., Hensley, K., Lawson, J.A., Marnett, L.J., Morrow, J.D., Murray, D.M., Plastaras, J., Roberts, L.J., Rokach, J., Shigenaga, M.K., Sohal, R.S., Sun, J., Tice, R.R., Van Thiel, D.H., Wellner, D., Walter, P.B., Tomer, K.B., Mason, R.P., Barrett, J.C. (2005) Biomarkers of Oxidative Stress Study II: Are oxidation products of lipids, proteins, and DNA markers of CC14 poisoning? Free Radic Biol Med. 38:698-710.

9. Kadiiska, M.B., Gladen, B.C., Baird, D.D., Graham, L.B., Parker, C.E., Ames, B.N, Basu S., FitzGerald, G.A., Lawson, J.A., Marnett, L.J., Morrow, J.D., Murray, D.M., Plastaras, J., Roberts, L.J., Rokach, J., Shigenaga, M.K., Sun, J., Walter, P.B., Tomer, K.B., Barrett, J.C. Mason, R.P. (2005) Biomarkers of Oxidative Stress Study III: Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CC14 poisoning? Free Radic Biol Med. 38:711-8.

10. McCann, J.C. and Ames, B.N. (2005) Is docosahexaenoic acid (DHA), an n-3 long chain polyunsaturated fatty acid, required for normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals: a review. Am J Clin Nutr. 82: 281-95.

11. Voloboueva, L.A., Liu, J., Suh, J.H., Ames, B.N. and Miller S.S. (2005) (R)-a-Lipoic Acid Protects Retinal Pigment Epithelial Cells From Oxidative Damage IOVS, 46:4302-4310.

12. Ames, B.N. (2005) Increasing Longevity by Tuning-up Metabolism, EMBO Reports, 6:S20-4.

13. Liu, J. and Ames, B.N. (2005) Mitochondrial nutrients: Reducing mitochondrial decay to delay or treat cognitive dysfunction, Alzheimer’s disease, and Parkinson’s disease, In: Neurodegenerative Disorders, Aging and Antioxidants. Editors Y. Luo and L. Packer.

14. Ames, B.N. (2005) DNA and Mitochondrial Damage from Inadequate Micronutrient Intake In: The Textbook of Functional Medicine, eds. D.S. Jones and S. Quinn, The Institute of Functional Medicine. Washington 397-412.

15. Ames, B.N., Suh, J. and Liu, J. (2006) Enzymes Lose Binding Affinity (increase Km) for Coenzymes and Substrates with Age: A Strategy for Remediation. In: Nutritional Genomics: Discovering the Path to Personalized Nutrition. Kaput, J. and Rodriguez, RL. (Eds). John Wiley and Sons, Inc., Hoboken, NJ. 277-291.

16. Kaput J, Ordovs, JM, Ferguson L, van Ommen B, Rodriguez RL, Allen L, Ames BN, et al. (2005) Horizons in Nutritional Science: The Case for Strategic International Alliances to Harness Nutritional Genomics for Public and Personal Health. British J Nutrition, 94:623-32.
    
    
17. Ames, B.N., Atamna, H. and Killilea, D. (2005) Review: Mineral and Vitamin Deficiencies Can Accelerate the Mitochondrial Decay of Aging. Molecular Aspects of Medicine, 26: 363-78.
    
    
18. Ames, B. (2005) The Metabolic Tune-up for Disease Prevention, FasterCures SmartBrief – Milken Institute, Milken Institute http://www.fastercures.org/sec/essay_ames.
    Offer, T., Bhagat, A., Lal, A., Atamna, W., Singer, S.T., Vichinsky, E.P., Kuypers, F.A. & Ames, B.N. (2005) Measuring Chromosome Breaks in Patients with Thalassemia. Ann. N.Y. Acad. Sci. 1054: 439-44.
    
    
19. Courtemanche, C., Huang, A.C., Elson-Schwab, I., Kerry, N., Ng, B.Y. and Ames, B.N. (2004) Folate deficiency and ionizing radiation cause DNA breaks in primary human lymphocytes: a comparison. FASEB J 18:209-11. doi:10.1096/fj.03-0382fje
    Ames, B.N. (2004) A Role for Supplements in Optimizing Health: The Metabolic Tune-Up. Arch Biochem Biophys., 423: 227-234.
    
    
20. Ames, B.N. (2004) Mitochondrial Decay, A Major Cause of Aging, Can Be Delayed. J. Alz. Dis., 6: 117-21.
    
    
21. Mashiyama, S., Courtemanche, C., Elson-Schwab, I., Crott, J., Lan Lee, B., NamOng, C., Fenech, M. and Ames, B.N. (2004) Uracil in DNA, determined by an improved assay, is increased when deoxynucleosides are added to folate-deficient cultured human lymphocytes. Analytical Biochemistry. 330: 58-69.
    
    
22. Killilea, D.W., Wong, S.L., Cahaya, H.S., Atamna, H., and Ames, B.N. (2004) Iron Accumulation during Cellular Senescence.  Ann NY Acad Sci 1019: 365-367.
    
    
23. Ames, B.N. (2004) Delaying the Mitochondrial Decay of Aging. Ann NY Acad Sci 1019: 406-411.
    
    
24. Ames, B.N. (2004) Supplements and Tuning Up Metabolism, J Nutr. 134:3164S-8S.
    
    
25. Liu, J., Head, E., Kuratsune, H., Cotman, C.W. and Ames, B.N. (2004) Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats. Ann NY Acad Sci. 1033: 117-131.
    
    
26. Ames, B.N. & Liu, J. (2004) Delaying the Mitochondrial Decay of Aging with Acetyl Carnitine. Ann NY Acad Sci. 1033: 108-116.
    
    
27. Courtemanche, C., Elson-Schwab, I., Mashiyama S.T., Kerry, N. and Ames B.N. (2004) Folate deficiency inhibits the proliferation of primary human CD8+ T lymphocytes in vitro. J Immunol. 173:3186-3192.
    
    
28. Offer, T., Ho, E., Traber, M.G., Bruno, R.S., Kuypers, F.A., and Ames B.N. (2005) A Simple Assay for Frequency of Chromosome Breaks and Loss (Micronuclei) by Flow Cytometry of Human Reticulocytes. FASEB J., 19:485-7 doi: 10.1096/fj.04-2729fje.
    
    
29. Jiang, Q., Wong, J. and Ames, B.N. (2004) g-Tocopherol induces apoptosis in androgen-responsive LNCaP prostate cancer cells via caspase dependent and independent mechanism. Ann NY Acad Sci, 1031:399-400.
    
    
30. Jiang, Q., Wong, J., Fyrst, H., Saba, J.D. and Ames, B.N. (2004) g-Tocopherol, or Combinations of Vitamin E Forms, Induce Cell Death In Human Prostate Cancer Cells By Interrupting Sphingolipid Synthesis. PNAS, 101: 17825-17830.
    
    
31. Cui, X., Han, Z., Fang, Z., Zuo P., Li, W. and Liu, J. (2004) D-Galactose-caused aging acceleration in Drosophila melanogaster and Musca domestica is associated oxidative stress. Biogerontology. 5(5):317-25.
    
    
32. Liu, J. and Mori. A. (2004) Stress-induced oxidative damage in the brain and neuroprotective effect of natural and nutritional antioxidants. Res. Commun. Brain and Nerve (Invited review, submitted).
    
    
33. Atamna, H. (2004) Review article: Heme, iron, and the mitochondrial decay of ageing. Ageing Res Rev. 3: 303-318.
    
    
34. Atamna, H. and Frey, W.H. (2004) A Role for Heme in Alzheimer’s Disease: Heme Binds Amyloid-b and has Altered Metabolism PNAS 101: 11153-58.
    
    
35. Suh, J., Wang, H., Liu, R.M., Liu, J. and Hagen, T.M. (2004) (R)-a-Lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis. Arch Biochem Biophys. 423:126-35.
    
    
36. Zhang X, Leung SM, Morris CR, Shigenaga MK. (2004) Evaluation of a novel, integrated approach using functionalized magnetic beads, bench-top MALDI-TOF-MS with prestructured sample supports, and pattern recognition software for profiling potential biomarkers in human plasma. J Biomol Tech. 15:167-75.
    
    
37. Ames, B.N. (2003) The Metabolic Tune Up: Metabolic Harmony and Disease Prevention. J. Nutr., 133:1544S-1548S.
    
    
38. Ames, B.N. (2003) Foreword. In: An Evidence-Based Approach to Vitamins and Minerals: Health Benefits and Intake Recommendations. Higdon, J., ed., Thieme Medical Publishers, New York, pp. 1-280.
    
    
39. Jacob, R.A., Aiello, G.M., Stephensen, C.B., Blumberg, J.B., Milbury, P.E., Wallock, L.M., and Ames, B.N. (2003) Moderate Antioxidant Supplementation has no Effect on Biomarkers of Oxidant Damage in Healthy Men with Low Fruit and Vegetable Intakes. J. Nutr., 133:740-743, 2003.
    
    
40. Jiang, Q. and Ames, B.N. (2003) _-Tocopherol, but not a-Tocopherol, Decreases Pro-inflammatory Eicosanoids and Inflammation Damage in Rats. FASEB J., 17:816-822
    
    
41. Ames, B.N. An Enthusiasm for Metabolism. J. Biol. Chem., 278: 4369-4380, February 14, 2003.
    
    
42. Gogvadze, V., Walter, P.B., and Ames, B.N. (2003) The Role of Fe2+-Induced Lipid Peroxidation in the Initiation of the Mitochondrial Permeability Transition. Arch. Biochem. Biophys., 414:255-260
    
    
43. Ames, B.N., Liu, J., Atamna, H. and Hagen, T. (2003) Delaying the mitochondrial decay of aging in the brain. Clinical Neuroscience Research, 2:331-338.
    
    
44. Ames, B.N. (2003) Review article: delaying the mitochondrial decay of aging—a metabolic tune-up. Alzheimer Disease and Associated Disorders, 17:54S-57S.
    
    
45. Killilea, D., Atamna, H., Liao, C. and Ames, B.N. (2003) Iron accumulation during cellular senescence in human fibroblasts in vitro. Antioxidants & Redox Signaling. 5:507-516.
    
    
46. Ho, E., Courtemanche, C. and Ames, B.N. (2003) Zinc deficiency induces oxidative DNA damage and increases P53 expression in human lung fibroblasts. J. Nutr. 133:2543-2548.
    
    
47. Jiang, Q., Blount, B. and Ames, B.N. (2003) 5-chlorouracil, a marker of DNA damage from hypochlorous acid during inflammation: a GC-MS assay. Journal of Biological Chemistry. 278:32834-32840.
    
    
48. Courtemanche, C., Huang, A.C., Elson-Schwab, I., Kerry, N., Ng, B.Y. and Ames, B.N. (2003) Folate deficiency and ionizing radiation cause DNA breaks inn primary human lymphocytes: a comparison. FASEB J., 10.1096/fj.03-0382fje.
    
    
49. Ames, B.N. and Gold, L.S. (2003) Cancer Prevention and the Environmental Chemical Distraction. In: Politicizing Science: the Alchemy of Policymaking. Michael Gough ed., Hoover Institute Press, Stanford. pp 116-142.
    
    
50. Ames, B. N. and Wakimoto, P. (2002) Are Vitamin and Mineral Deficiencies a Major Cancer Risk? Nat. Rev. Cancer 2, 694-704.
    
    
51. Atamna, H., Killilea, D.W., Killilea, A.N., and Ames, B.N. (2002) Heme Deficiency May Be a Factor in the Mitochondrial and Neuronal Decay of Aging. Proc. Natl. Acad. Sci. U.S.A. 99, 14807-14812.
    
    
52. Walter, P.B., Knutson, M.D., Paler-Martinez, A., Lee, S., Xu, Y., Viteri, F.E., and Ames, B.N. (2002) Iron Deficiency and Iron Excess Damage Mitochondria and Mitochondrial DNA in Rats. Proc. Natl. Acad. Sci. U.S.A. 99, 2264-2269.
    
    
53. Ho, E., and Ames, B.N. (2002) Low Intracellular Zinc Induces Oxidative DNA Damage, Disrupts p53, NFkB and AP1 DNA Binding, and Affects DNA Repair in a Rat Glioma Cell Line. Proc Natl Acad Sci U S A 99, 16770-16775.
    
    
54. Ames, B. N., Elson-Schwab, I., and Silver, E. (2002) High-Dose Vitamins Stimulate Variant Enzymes with Decreased Coenzyme-Binding Affinity (Increased Km): Relevance to Genetic Disease and Polymorphisms. Am J. Clin. Nutr. 75, 616-658.
    
    
55. Hagen, T.M., Liu, J., Lykkesfeldt, J., Wehr, C.M., Ingersoll, R.T., Vinarsky, V., Bartholomew, J.C., and Ames, B.N. (2002) Feeding Acetyl-L-Carnitine and Lipoic Acid to Old Rats Significantly Improves Metabolic Function while Decreasing Oxidative Stress. Proc. Natl. Acad. Sci. U.S.A. 99, 1870-1875.
    
    
56. Liu, J., Head, E., Gharib, A.M., Yuan, W., Ingersoll, R.T. Hagen, T.M., Cotman, C.W., and Ames, B.N. (2002) Memory Loss in Old Rats is Associated with Brain Mitochondrial Decay and RNA/DNA Oxidation: Partial Reversal by Feeding Acetyl-L-Carnitine and/or R-a-Lipoic Acid. Proc. Natl. Acad. Sci. U.S.A. 99, 2356-2361.
    
    
57. Liu, J., Killilea, D.W., and Ames, B.N. (2002) Age-associated Mitochondrial Oxidative Decay: Improvement of Carnitine Acetyltransferase Substrate Binding Affinity and Activity in Brain by Feeding Old Rats Acetyl-L-Carnitine and/or R-a-Lipoic Acid. Proc. Natl. Acad. Sci. U.S.A. 99, 1876-1881.
    
    
58. Jiang, Q. and Ames, B.N. (2003) g-Tocopherol, but not a-Tocopherol, Decreases Pro-inflammatory Eicosanoids and Inflammation Damage in Rats. FASEB J., May;17(8):816-22.
    
    
59. Jiang Q, Christen S, Shigenaga MK and Ames BN. (2001) g_Tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr. 2001 Dec;74(6):714-22.
    
    
60. Wallock, L.M., et al., Low seminal plasma folate concentrations are associated with low sperm density and count in male smokers and nonsmokers. Fertil. Steril., 2001. 75: p. 252-259.