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CHORI CURRENT News

2017

CHORI’s Dan M. Granoff Awarded Prestigious Alumni Award from the Johns Hopkins University, School of Medicine

Oakland, CA (July 21, 2017) – Children’s Hospital Oakland Research Institute (CHORI) Senior Scientist Dr. Dan M. Granoff, has been awarded the 2017 Distinguished Medical Alumnus Award from his alma mater, the Johns Hopkins University School of Medicine.

The Distinguished Medical Alumnus Award honors those alumni (degree recipients, current and former faculty, fellows and house staff) of the Johns Hopkins University School of Medicine and the Johns Hopkins Hospital who have demonstrated excellence and achievement through their personal and professional accomplishments.

Dan M. Granoff (left), William Henry Welch, Founding Physician and First Dean of the Johns Hopkins School of Medicine (photo frame), and Paul B. Rothman, Dean of the Medical School Faculty (right).

Dr. Granoff received both his A.B. and MD from Johns Hopkins University and was a Pediatric Resident at Johns Hopkins Hospital.  He currently holds the Clorox Endowed Chair and is Director of the Center for Immunobiology and Vaccine Development at CHORI, UCSF Benioff Children’s Hospital Oakland’s research arm. Previously, he was Professor of Pediatrics and Associate Professor of Molecular Microbiology at Washington University School of Medicine, St. Louis, Missouri, and Director of Pediatric Infectious Diseases at St. Louis Children’s Hospital.  

Dr. Granoff is an author or co-author of more than 220 articles in infectious disease microbiology and vaccine research. In the 1980's, he conducted clinical studies and investigated the molecular basis of protective human antibody responses to Haemophilus influenzae type b polysaccharide and conjugate vaccines. His proposal in 1999 to the World Health Organization demonstrated feasibility of developing a low-cost meningococcal conjugate vaccine for Africa, which led to introduction of a vaccine that controls epidemics in the region. His work since 2003 on a new meningococcal antigen, called Factor H binding protein, which is now part of two licensed vaccines, demonstrated the importance of the protein for the ability of the bacteria to evade human host defenses, and how the protein can be mutated to create a vaccine with improved breadth of protective antibody responses.  In 2014, he was the recipient of the Maurice Hilleman/Merck Laureate award by the American Society of Microbiology for outstanding contributions to vaccine discovery and development.

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Lipoprotein Abnormalities Contribute to Sickle Cell Disease Pathology
Newswire Press Release: "An article published in Experimental Biology and Medicine (Volume 242, Issue 12, June, 2017) links imbalances in lipoprotein metabolism with vaso-occlusive events in patients with sickle cell disease (SCD). The study, led by Dr. Eric Soupene in Dr. Frans Kuypers’ laboratory at the Children’s Hospital Oakland Research Institute (CHORI) in Oakland CA, identified high density lipoprotein (HDL) metabolites in SCD plasma that promote inflammation and may reduce the effectiveness of current therapies."
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Click here to download Abstract of article in Experimental Biology and Medicine.

The Vitamin Lipoic Acid Prevents Kidney Stones in Mouse Model of a Rare Genetic Disease
Cystinuria is caused by a mutation in a protein that transports the amino acid cysteine in the kidney and GI. The main clinical impact of the disease in a build up of cysteine in the urine, which then aggregates and forms painful kidney stones in children and adults. Stone formation can be quite rapid and frequent, leading to a poor quality of life. Few medications exist for these patients, and all have significant side effects. In a study conducted by The Buck Institute for Research on Aging and UCSF Department of Urology, high doses of the natural vitamin lipoic acid was found to shutdown cystine stone formation in mice with the same genetic defect as found in human cystinuria. Moreover, the benefits of lipoic acid happened quickly and without any detectable side effects (other than smelly urine). The UCSF clinical team is now recruiting for a clinical trial to determine if lipoic acid will be effective in cystinuria patients. UCSF Benioff Children's Hospital Oakland Research Institute scientist David Killilea, with joint appointment in the UCSF Department of Urology, contributed to this study.
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Click here to download the article.
Clinical study: https://clinicaltrials.gov/ct2/show/NCT02910531

CHORI Scientist receives $100,000 grant from Abate Med to help find a lasting treatment for Atopic Dermatitis
Laura Hertel, PhD, a virologist at Children’s Hospital Oakland Research Institute (CHORI), has received a grant from Abate Med’s founder, Dr. David Paslin, for a pre-clinical study on the efficacy of using a protein made by a common virus that infects the skin, to treat the cutaneous manifestations of atopic dermatitis.
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CHORI Study Reveals Improved Zinc Intake Reduces Damage to DNA
Low intake of the mineral zinc is common throughout the world, resulting in poor pregnancy outcomes for mothers and weakened the health & development of children. Yet robust biomarkers of inadequate zinc intake are lacking. A study conducted by UCSF Benioff Children's Hospital Oakland Research Institute scientist Janet King showed that even small increases in zinc intake translate to reduced DNA damage in immune cells, as wells as restored levels of key circulating proteins involved in DNA repair, antioxidant activity, and immune function. The study, “A moderate increase in diet zinc reduced DNA strand breaks in leukocytes and altered plasma proteins without changing plasma zinc concentrations,” was authored by Sarah Zyba, Swapna Shenvi, David Killilea, Tai Holland, Elijah Kim, Adrian Moy, Barbara Sutherland, Virginia Gildengorin, Mark Shigenaga, and Janet King and featured in the February, 2017 issue of the American Journal of Clinical Nutrition. The study was funded by HarvestPlus and NIH/ODS.
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Monday, September 11, 2017 2:31 PM

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