Oakland Study Shows Improvements in Adolescents whose Asthma is Poorly Controlled

Oakland, CA (December 1, 2018) - A pilot clinical trial by UCSF Benioff Children’s Hospital Oakland Research Institute (CHORI) researchers has found that targeted nutrient therapy can improve lung function in obese individuals with asthma, without requiring weight loss. The study, published in The FASEB Journal, demonstrated that eating two CHORI-bars daily for eight weeks improved lung function in obese adolescents with a form of asthma that is resistant to usual treatments.

Bruce Ames, PhD, senior scientist at CHORI and senior author of the FASEB paper, along with his colleague Mark Shigenaga, PhD, a co-author and expert in gut health, originated the idea for the CHORI-bar, a patent-pending supplement bar designed to fill nutritional gaps in poor diets. The bar was developed over a period of 10 years, guided by some 15 small clinical trials, by a team of scientists in Ames’ group at CHORI, in collaboration with the USDA’s Healthy Processed Foods Research Unit.

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University of California press release: "Adequate Consumption of ‘Longevity’ Vitamins Could Prolong Healthy Aging"

Oakland, CA (October 15, 2018) – Dr. Bruce Ames, after more than a decade of research in the Nutrition and Metabolism Center of UCSF Benioff Children's Hospital Oakland Research Institute, has published a "perspective" article in the Proceedings of the National Academy of Sciences.

In this new review of nutritional science, Dr. Ames argues that most American diets are deficient in a key class of vitamins and minerals that play previously unrecognized roles in promoting longevity and in staving off chronic diseases such as heart disease, cancer and, potentially, neurodegeneration.

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Research Study Correlates Obesity in Preschoolers with Screen Time and Sociodemographic Factors

Oakland, CA (March 5, 2018) – A new study by UCSF Benioff Children's Hospital Oakland researcher Dr. June Tester, MD, MPH examined national data on preschool-aged children from 1999 to 2014 to highlight characteristics of children with the highest degree of obesity and found a strong correlation between the amount of “screen time” these children are exposed to and the likelihood of being severely obese. The study also found that preschoolers with severe obesity are also more likely to be of an ethnic or racial minority and to be living in poverty.

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Click here to download the article in Pediatrics, March 2018

CHORI Study Suggests Human Antibody Structure May be Key to Improving Effectiveness of Meningococcal Vaccines

Oakland, CA  (February 16, 2018) - Research conducted by UCSF Benioff Children's Hospital Oakland Research Institute (CHORI) scientists recently identified the molecular details of a human antibody raised by a vaccine for prevention of bacterial meningitis and sepsis. The study, “Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal FHbp,” by CHORI scientists Peter Beernink, PhD and the late
Alex Lucas, PhD, in collaboration with scientists at GlaxoSmithKline, recently was published in the journal Nature Communications. They report the crystal structure of a human antibody bound to a meningococcal serogroup B vaccine antigen known as Factor H binding protein. The research finding is the first example of a structure of a human antibody raised by vaccination bound to its target antigen.

Building on a previous study in which the scientists isolated human antibodies from single white blood cells shortly after vaccination with a meningococcal serogroup B vaccine, Dr. Beernink and colleagues obtained three-dimensional structures of a fragment of the antibody, alone and bound to the antigen. The antibody was of major interest because it bound to all natural variants of the antigen. This broad reactivity demonstrates that a human antibody raised by vaccination with a meningococcal B vaccine, may have the potential to contribute to broad protection against diverse strains of the bacterium Neisseria meningitidis - also known as meningococcus. The structure highlighted the difference between human and mouse antibodies to the antigen, which, in combination with other research being pursued at CHORI, will support the development of improved meningococcal B vaccines.

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Click here to download the article in Nature Communications, February 6, 2018


Friday, January 18, 2019 9:15 AM

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