CHORI News Archives
New Findings on Gut Microbiomes and Longevity
Inadequate Zinc increases Risk for Kidney Stones in Adolescents
Researchers Discover a New Gatekeeper Role for Thymic Dendritic Cells in Controlling T Cell Release into the Bloodstream: Better Understanding of Cell's Role Could Lead to New Strategies to Treat Autoimmune Diseases, Cancer
The study “Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress,” appeared in the ‘Journal of Experimental Medicine’ (November 14, 2016 issue), published by Rockefeller University Press (http://jem.rupress.org/content/213/12/2773).
CHORI Research on Genome Editing for a Sickle Cell Cure Receives nearly $4.5 million from the California Institute for Regenerative Medicine
The funding is part of the Translational Award program, which has a goal of moving the most promising projects out of the laboratory and into clinical trials in people.
Dr. Walters' research uses a genetic editing tool, CRISPR-Cas9, to help find a cure for sickle cell disease. The research involves taking the patient’s own blood stem cells, using CRISPR-Cas9 to correct the genetic mutation causing the disease, and then return those cells to the patient. It’s hoped the “corrected” blood stem cells will then multiply and create a new blood system, one free of sickle cell. The funding from CIRM will enable Dr. Walters' team to do the preliminary testing and research needed to get this project ready for a clinical trial.
UCSF Benioff Children’s Hospitals and Partners to Receive $1.2 Million Grant from California Initiative to Advance Precision Medicine
Major children’s hospitals such as the UCSF Benioff Children’s Hospitals often see patients who have unusual and severe inborn conditions that appear to be genetic, but the gene responsible for the disorder is unknown. The CIAPM-supported project, “Full Genome Analysis of Children to Guide Precision Medicine” led by Dr. David Martin of the Children’s Hospital Oakland Research Institute (CHORI), will help advance precision medicine by developing methods that improve our ability to identify mutations that cause inherited diseases, and to find the cause of such difficult-to-diagnose genetic conditions.
Genome engineering paves the way for sickle cell cure: Repairing the sickle cell mutation in stem cells holds promise for new treatment
The researchers from UC San Francisco Benioff Children’s Hospital Oakland Research Institute (CHORI), the University of California, Berkeley and the University of Utah School of Medicine hope to re-infuse patients with the edited stem cells and alleviate symptoms of the disease, which primarily afflicts those of African descent and leads to anemia, painful blood blockages and early death.
In tests in mice, the genetically engineered stem cells stuck around for at least four months after transplantation, an important benchmark to ensure that any potential therapy would be lasting.
“This is an important advance because for the first time we show a level of correction in stem cells that should be sufficient for a clinical benefit in persons with sickle cell anemia,” said co-author Mark Walters, a pediatric hematologist and oncologist and director of UCSF Benioff Oakland’s Blood and Marrow Transplantation Program.
The results will be reported in the Oct. 12, 2016 issue of the online journal Science Translational Medicine (http://stm.sciencemag.org/content/8/360/360ra134).
Ellen Fung, PhD RD (CHORI) and her colleagues Laura Bachrach, MD (Stanford) and Aenor Sawyer, MD (UCSF) just published the 2nd edition of the text, Bone Health Assessment in Pediatrics: Guidelines for Clinical Practice (Springer, 2016). The text is the gold-standard resource for evaluating bone health in children and adolescents. Authors include an international panel of experts in measuring and analyzing bone density in the pediatric patient, and chapters reflect the most recent International Society for Clinical Densitometry (ISCD) Guidelines for Pediatric DXA assessment, interpretation and reporting. This indispensable reference covers all the important changes in the field over the last decade. Some highlights of this edition include: an entire chapter on the assessment of infants and toddlers, a chapter devoted to the assessment of children with disabling conditions, an in-depth discussion of vertebral fracture and its etiologies, and a thorough review of the advantages and limitations of densitometry techniques including DXA, pQCT, HRpQCT, and MRI. Solidifying itself as the leading text in the field, Bone Health Assessment in Pediatrics: Guidelines for Clinical Practice, 2nd ed. provides all of the critical basic analysis and evaluation tools, images, and calculations necessary for both researchers as well as practicing clinicians.
CHORI Study Reveals Potential Improvements for Effectiveness of Meningococcal Vaccines
The study, “Enhanced Protective Antibody to a Mutant Meningococcal Factor H-Binding Protein with Low Factor H Binding,” authored by Children’s Hospital Oakland Research Institute (CHORI) scientists Dan Granoff, MD, and Peter Beernink, PhD was featured in the September 8th, 2016 issue of the Journal of Clinical Investigation Insight.
SJND Students Intern at Stanford, Children’s Hospital Oakland Labs
35th Annual CHORI Summer Student Research Symposium:
Monday, September 11, 2017 1:59 PM