Fighting Disease by Optimizing Nutrition
CHORI Researchers Develop Low-Calorie Nutritional Bar that Improves Metabolic Biomarkers Linked to Disease Risk in a Two-Week Trial
"Increased HDL-c is associated with better protection against cardiovascular disease, while lower Hcy concentrations is associated with better protection against both heart disease and cognitive decline. And glutathione protects the cell against environmental stresses, so increasing GSH is also a very positive sign."
CHORI Senior Scientist Bruce Ames, PhD, and CHORI Assistant Scientist Mark Shigenaga, PhD began the development of the CHORI-Bar over 8 years ago to fill two important gaps in the standard American diet, which is high in calories, fat, and sugar but low in fiber and micronutrients. The CHORI-Bar was specifically designed to address these gaps.
Carefully formulated to be both tasty and complete in nutrition, the CHORI-Bar is engineered to provide those nutrients required for maximum function of a healthy gut, while also providing key micronutrients and minerals. In addition, the bar is only 110 calories. And unlike many nutritional interventions that require participants to completely change their diets, the CHORI-Bar is meant to be consumed in the background of an individual's normal diet.
This makes the significance of the metabolic changes observed after a mere two-week trial all the more exciting and surprising.
As Dr. McCann explains, "It is very difficult to both raise HDL-c and lower homocysteine with drugs and even most special diets, so the ability of the CHORI-bar to do this in only 2-weeks with no special dietary instructions is very enouraging."
In addition, the CHORI-Bar is also a testament to the power of balanced nutrition and the right mixture of nutrients.
"When individual nutrients in the CHORI-Bar are taken separately in supplement form, quite high amounts are needed in order to have effects like those we are seeing with the CHORI-Bar," says Dr. Shigenaga. "What is critically different here is that we are supplying these different nutrients together in a balanced combination at amounts typically found in food. The overall affect of the CHORI-Bar may well be due to the power of delivering them all together with a synergistic effect."
Positive results from additional trials are already being assembled for publication, and the Ames group is planning additional studies, both to evaluate the mechanisms behind the metabolic changes and to quantify differences in metabolic shifts between different types of individuals.
Sunday, July 29, 2012 12:45 PM