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TRANSLATing GENETIC tools into Treatment, Prevention & Cures
Translational Research in The Center for Genetics

With improve-ments in the care of premature babies, birth defects are now the leading cause of infant mortality in the country. Prevention has become more and more important. - Edward Lammer, MD
Basic research in genetics only provides the tools for prevention and cure when the results of that research are directly translated into the clinical setting. Investigators in CHORI's Center for Genetics strive to use the potential that unraveling the genetics of disease holds to improve health and wellness across the globe.

Co-investigator for the internationally recognized California Center for Excellence in Surveillance, Research Service and Evaluation of Birth Defects, Edward Lammer, MD, provides clinical genetic expertise to the National Birth Defects Prevention Study, a collaborative, 9-state birth defects research consortium. The NBDPS is the largest case-control study of birth defects ever conducted, enrolling children with 30 different major birth defects and banking thousands of DNA samples from affected children and parents annually. A central research focus of the California Center is the role of maternal nutrition during pregnancy in preventing birth defects.

Director of the Children’s Hospital Oakland (CHO) Human Leukocyte Antigen (HLA) Clinical Laboratory and diplomat of the American Board of Histocompatibility and Immunogenetics (ABHI), Elizabeth Trachtenberg, PhD, investigates the roles of HLA and Natural Killer Immunoglobulin-like Receptor (KIR) complexes in stem cell transplantation outcome. Under Dr. Trachtenberg’s direction, the HLA lab is one of four laboratories in the nation that act as ASHI/CAP referees for HLA class I and class II DNA and serological tying proficiency surveys.

These are but two examples of translational research in CHORI's Center for Genetics. Explore the Investigator links in the sidebar menu to discover all the ways in which CHORI's Center for Genetics bridges the gap between the bench and the bedside to provide unparalleled breakthroughs in translational research.

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