Uses of Natural Folates for Protection Against Radiation Damage

Case Number CH-058

Inventors: Tal Offer, PhD

Patent No. Title Issue Date Country
Pending Uses of Reduced Folates for Protection Against Radiation Damage   United States

Abstract
The invention provides methods and compositions for protecting cells from oxidative stress and delay cell senescence at effective concentrations that are orders of magnitude lower than previously reported therapeutic doses of methylene blue.

Since first synthesized in 1876, methylene blue has been used for a variety of medicinal purposes. For example it has been reported useful in the treatment of bipolar manic-depressive patients, the management of chronic renal calculous disease and the improvement of oxidative metabolism and memory retention in rats.

Advantage
The formulations of methylene blue covered by the patents enabled effective concentrations that are orders of magnitude lower than previously reported therapeutic doses of methylene blue. The delay of cell senescence in an individual determined to have cells in need of delayed cell senescence may also include potential health benefits, such as improved skin elasticity, wrinkle reduction, and/or increased energy levels.

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